Strategies for improving plasmid stability in genetically modified bacteria in bioreactors

Kumar PKR, Maschke H-E, Friehs K, Schügerl K (1991)
Trends in biotechnology 9(1): 279-284.

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Abstract
Exploitation of recombinant organisms for the large-scale, commercial production of foreign proteins is often hampered by the problem of plasmid instability. A wide range of strategies have been reported for improving the stability of recombinant organisms. A combination of manipulating both the genetic design of recombinants and the conditions of culturing the organisms may be used to achieve stable host-vector associations during culture of recombinant organisms in bioreactors.
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Kumar PKR, Maschke H-E, Friehs K, Schügerl K. Strategies for improving plasmid stability in genetically modified bacteria in bioreactors. Trends in biotechnology. 1991;9(1):279-284.
Kumar, P. K. R., Maschke, H. - E., Friehs, K., & Schügerl, K. (1991). Strategies for improving plasmid stability in genetically modified bacteria in bioreactors. Trends in biotechnology, 9(1), 279-284.
Kumar, P. K. R., Maschke, H. - E., Friehs, K., and Schügerl, K. (1991). Strategies for improving plasmid stability in genetically modified bacteria in bioreactors. Trends in biotechnology 9, 279-284.
Kumar, P.K.R., et al., 1991. Strategies for improving plasmid stability in genetically modified bacteria in bioreactors. Trends in biotechnology, 9(1), p 279-284.
P.K.R. Kumar, et al., “Strategies for improving plasmid stability in genetically modified bacteria in bioreactors”, Trends in biotechnology, vol. 9, 1991, pp. 279-284.
Kumar, P.K.R., Maschke, H.-E., Friehs, K., Schügerl, K.: Strategies for improving plasmid stability in genetically modified bacteria in bioreactors. Trends in biotechnology. 9, 279-284 (1991).
Kumar, P. K. R., Maschke, H.-E., Friehs, Karl, and Schügerl, K. “Strategies for improving plasmid stability in genetically modified bacteria in bioreactors”. Trends in biotechnology 9.1 (1991): 279-284.
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