Poly(oxyethylene) based surface coatings for poly(dimethylsiloxane) microchannels

Hellmich W, Regtmeier J, Duong TT, Ros R, Anselmetti D, Ros A (2005)
Langmuir 21(16): 7551-7557.

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Abstract
Control of surface properties in microfluidic systems is an indispensable prerequisite for successful bioanalytical applications. Poly(dimethylsiloxane) (PDMS) microfluidic devices are hampered from unwanted adsorption of biomolecules and lack of methods to control electroosmotic flow (EOF). In this paper, we propose different strategies to. coat PDMS surfaces with poly(oxyethylene) (POE) molecules of varying chain lengths. The native PDMS surface is pretreated by exposure to UV irradiation or to an oxygen plasma, and the covalent linkage of POE-silanes as well as physical adsorption of a triblock-copolymer (F108) are studied. Contact angle measurements and atomic force microscopy (AFM) imaging revealed homogeneous attachment of POE-silanes and F108 to the PDMS surfaces. In the case of F108, different adsorption mechanisms to hydrophilic and hydrophobic PDMS are discussed. Determination of the electroosmotic mobilities of these coatings in PDMS microchannels prove their use for electrokinetic applications in which EOF reduction is inevitable and protein adsorption has to be suppressed.
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Hellmich W, Regtmeier J, Duong TT, Ros R, Anselmetti D, Ros A. Poly(oxyethylene) based surface coatings for poly(dimethylsiloxane) microchannels. Langmuir. 2005;21(16):7551-7557.
Hellmich, W., Regtmeier, J., Duong, T. T., Ros, R., Anselmetti, D., & Ros, A. (2005). Poly(oxyethylene) based surface coatings for poly(dimethylsiloxane) microchannels. Langmuir, 21(16), 7551-7557.
Hellmich, W., Regtmeier, J., Duong, T. T., Ros, R., Anselmetti, D., and Ros, A. (2005). Poly(oxyethylene) based surface coatings for poly(dimethylsiloxane) microchannels. Langmuir 21, 7551-7557.
Hellmich, W., et al., 2005. Poly(oxyethylene) based surface coatings for poly(dimethylsiloxane) microchannels. Langmuir, 21(16), p 7551-7557.
W. Hellmich, et al., “Poly(oxyethylene) based surface coatings for poly(dimethylsiloxane) microchannels”, Langmuir, vol. 21, 2005, pp. 7551-7557.
Hellmich, W., Regtmeier, J., Duong, T.T., Ros, R., Anselmetti, D., Ros, A.: Poly(oxyethylene) based surface coatings for poly(dimethylsiloxane) microchannels. Langmuir. 21, 7551-7557 (2005).
Hellmich, Wibke, Regtmeier, Jan, Duong, Thanh Tu, Ros, Robert, Anselmetti, Dario, and Ros, Alexandra. “Poly(oxyethylene) based surface coatings for poly(dimethylsiloxane) microchannels”. Langmuir 21.16 (2005): 7551-7557.
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