Indication of methamphetamine-induced reactive synaptogenesis in the prefrontal cortex of gerbils (Meriones unguiculatus).

Dawirs RR, Teuchert-Noodt G, Molthagen M (1993)
Eur J Pharmacol 241(1): 89-97.

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Zeitschriftenaufsatz | Veröffentlicht | Englisch
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Abstract / Bemerkung
A single dose of methamphetamine (25 mg/kg i.p.) was administered to young adult gerbils (Meriones unguiculatus) aged 90 days and the number of spices was determined along 40-microns segments of basal, lateral and apical dendrites of pyramidal cells in layers III and V of the prefrontal cortex, after 1.5, 7, 20 and 30 days. The density of spines rapidly increased by more than 80% within 7 days after drug challenge, and subsequently returned to the original normal values within about 2 weeks. Thirty days after drug administration the density of dendritic spines was slightly, but significantly, less than control values (about 5%). The density of spines was likewise affected in layer III and V neurones, irrespective of the spatial domain of their dendritic ramifications. Since several lines of investigation indicate that methamphetamine can cause the destruction of dopaminergic nerve terminals in the mammalian forebrain, the present results are discussed against the background of current concepts about reactive synaptic reorganization and adaptive remodelling of neural circuits in the central nervous system.
Erscheinungsjahr
Zeitschriftentitel
Eur J Pharmacol
Band
241
Zeitschriftennummer
1
Seite
89-97
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Dawirs RR, Teuchert-Noodt G, Molthagen M. Indication of methamphetamine-induced reactive synaptogenesis in the prefrontal cortex of gerbils (Meriones unguiculatus). Eur J Pharmacol. 1993;241(1):89-97.
Dawirs, R. R., Teuchert-Noodt, G., & Molthagen, M. (1993). Indication of methamphetamine-induced reactive synaptogenesis in the prefrontal cortex of gerbils (Meriones unguiculatus). Eur J Pharmacol, 241(1), 89-97. doi:10.1016/0014-2999(93)90937-D
Dawirs, R. R., Teuchert-Noodt, G., and Molthagen, M. (1993). Indication of methamphetamine-induced reactive synaptogenesis in the prefrontal cortex of gerbils (Meriones unguiculatus). Eur J Pharmacol 241, 89-97.
Dawirs, R.R., Teuchert-Noodt, G., & Molthagen, M., 1993. Indication of methamphetamine-induced reactive synaptogenesis in the prefrontal cortex of gerbils (Meriones unguiculatus). Eur J Pharmacol, 241(1), p 89-97.
R.R. Dawirs, G. Teuchert-Noodt, and M. Molthagen, “Indication of methamphetamine-induced reactive synaptogenesis in the prefrontal cortex of gerbils (Meriones unguiculatus).”, Eur J Pharmacol, vol. 241, 1993, pp. 89-97.
Dawirs, R.R., Teuchert-Noodt, G., Molthagen, M.: Indication of methamphetamine-induced reactive synaptogenesis in the prefrontal cortex of gerbils (Meriones unguiculatus). Eur J Pharmacol. 241, 89-97 (1993).
Dawirs, R R, Teuchert-Noodt, Gertraud, and Molthagen, M. “Indication of methamphetamine-induced reactive synaptogenesis in the prefrontal cortex of gerbils (Meriones unguiculatus).”. Eur J Pharmacol 241.1 (1993): 89-97.

6 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Activity-dependent structural plasticity.
Butz M, Wörgötter F, van Ooyen A., Brain Res Rev 60(2), 2009
PMID: 19162072
Developmental pattern changes of prefrontal efferents in the juvenile gerbil (Meriones unguiculatus).
Witte AV, Brummelte S, Teuchert-Noodt G., J Neural Transm (Vienna) 114(11), 2007
PMID: 17557126
Long-term effects of a single adult methamphetamine challenge: minor impact on dopamine fibre density in limbic brain areas of gerbils.
Brummelte S, Grund T, Czok A, Teuchert-Noodt G, Neddens J., Behav Brain Funct 2(), 2006
PMID: 16569246
Pharmacologically induced neural plasticity in the prefrontal cortex of adult gerbils (Meriones unguiculatus).
Dawirs RR, Teuchert-Noodt G, Nossoll M., Eur J Pharmacol 327(2-3), 1997
PMID: 9200549

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