The postnatal maturation of dopamine innervation in the prefrontal cortex of gerbils (Meriones unguiculatus) is sensitive to an early single dose of methamphetamine. A quantitative immunocytochemical study.

Dawirs RR, Teuchert-Noodt G, Czaniera R (1994)
J Hirnforsch 35(2).

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Zeitschriftenaufsatz | Veröffentlicht | Englisch
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Abstract / Bemerkung
Dopamine (DA)-immunoreactivity was investigated in the prefrontal cortex (PFC) of 90 day old adult male gerbils (Meriones unguiculatus) after they had received a single dose of either methamphetamine (50 mg/kg; i.p.) or saline at the age of postnatal day 14. For that purpose, a selective and sensitive antibody directed against glutaraldehyde-conjugated dopamine was applied. All detectable fragments of dopamine-immunoreactive fibres were identified in consecutive frontal sections of the pregenual prefrontal cortex, and their total numbers and total length were determined in the medial (mPFC) and orbital prefrontal cortex (oPFC). The results indicate that a single application of methamphetamine during early postnatal development caused a significant and severe restraint of the subsequent maturation of the prefrontal dopamine-innervation. Although, on postnatal day 14, the total dopamine-immunoreactivity had only attained about 4% (mPFC) and 7% (oPFC) of the regular adult values, this solitary pharmacological challenge entailed final adult innervation densities which were about 38% (mPFC) and 50% (oPFC) below those of the controls. Considering the pivotal role which mesoprefrontal dopaminergic afferents play in morphogenesis and regular functioning, the present results are discussed with current understanding of structural and functional plasticity during maturation of the prefrontal cortex.
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Zeitschriftentitel
J Hirnforsch
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35
Zeitschriftennummer
2
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Dawirs RR, Teuchert-Noodt G, Czaniera R. The postnatal maturation of dopamine innervation in the prefrontal cortex of gerbils (Meriones unguiculatus) is sensitive to an early single dose of methamphetamine. A quantitative immunocytochemical study. J Hirnforsch. 1994;35(2).
Dawirs, R. R., Teuchert-Noodt, G., & Czaniera, R. (1994). The postnatal maturation of dopamine innervation in the prefrontal cortex of gerbils (Meriones unguiculatus) is sensitive to an early single dose of methamphetamine. A quantitative immunocytochemical study. J Hirnforsch, 35(2)
Dawirs, R. R., Teuchert-Noodt, G., and Czaniera, R. (1994). The postnatal maturation of dopamine innervation in the prefrontal cortex of gerbils (Meriones unguiculatus) is sensitive to an early single dose of methamphetamine. A quantitative immunocytochemical study. J Hirnforsch 35.
Dawirs, R.R., Teuchert-Noodt, G., & Czaniera, R., 1994. The postnatal maturation of dopamine innervation in the prefrontal cortex of gerbils (Meriones unguiculatus) is sensitive to an early single dose of methamphetamine. A quantitative immunocytochemical study. J Hirnforsch, 35(2).
R.R. Dawirs, G. Teuchert-Noodt, and R. Czaniera, “The postnatal maturation of dopamine innervation in the prefrontal cortex of gerbils (Meriones unguiculatus) is sensitive to an early single dose of methamphetamine. A quantitative immunocytochemical study.”, J Hirnforsch, vol. 35, 1994.
Dawirs, R.R., Teuchert-Noodt, G., Czaniera, R.: The postnatal maturation of dopamine innervation in the prefrontal cortex of gerbils (Meriones unguiculatus) is sensitive to an early single dose of methamphetamine. A quantitative immunocytochemical study. J Hirnforsch. 35, (1994).
Dawirs, R R, Teuchert-Noodt, Gertraud, and Czaniera, R. “The postnatal maturation of dopamine innervation in the prefrontal cortex of gerbils (Meriones unguiculatus) is sensitive to an early single dose of methamphetamine. A quantitative immunocytochemical study.”. J Hirnforsch 35.2 (1994).

13 Zitationen in Europe PMC

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Activity-dependent structural plasticity.
Butz M, Wörgötter F, van Ooyen A., Brain Res Rev 60(2), 2009
PMID: 19162072
Effect of postnatal methamphetamine trauma and adolescent methylphenidate treatment on adult hippocampal neurogenesis in gerbils.
Schaefers AT, Teuchert-Noodt G, Bagorda F, Brummelte S., Eur J Pharmacol 616(1-3), 2009
PMID: 19540225
Alteration in the GABAergic network of the prefrontal cortex in a potential animal model of psychosis.
Brummelte S, Neddens J, Teuchert-Noodt G., J Neural Transm (Vienna) 114(5), 2007
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PMID: 17557126
The maturation of the acetylcholine system in the dentate gyrus of gerbils (Meriones unguiculatus) is affected by epigenetic factors.
Busche A, Bagorda A, Lehmann K, Neddens J, Teuchert-Noodt G., J Neural Transm (Vienna) 113(2), 2006
PMID: 15959847
Long-term effects of a single adult methamphetamine challenge: minor impact on dopamine fibre density in limbic brain areas of gerbils.
Brummelte S, Grund T, Czok A, Teuchert-Noodt G, Neddens J., Behav Brain Funct 2(), 2006
PMID: 16569246
Serotonin fibre densities in subcortical areas: differential effects of isolated rearing and methamphetamine.
Lehmann K, Lesting J, Polascheck D, Teuchert-Noodt G., Brain Res Dev Brain Res 147(1-2), 2003
PMID: 14741759

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