Ontogeny of PFC-related behaviours is sensitive to a single non-invasive dose of methamphetamine in neonatal gerbils (Meriones unguiculatus).

Dawirs RR, Teuchert-Noodt G, Czaniera R (1996)
J Neural Transm 103(11): 1235-1245.

Journal Article | Published | English

No fulltext has been uploaded

Author
; ;
Abstract
A single dose of methamphetamine (50 mg/kg; i.p.) was administered to neonatal male gerbils (Meriones unguiculatus) aged 14 days, and adult prefrontal cortex (PFC)-related behaviours were analysed and compared with saline-treated controls at the age of postnatal day 90. For that purpose, animals were tested for open-field activities and y-maze delayed alternation. This solitary and non-invasive drug challenge, which has recently been found to initiate serious restraint in maturation of the mesoprefrontal dopamine (DA)-system (Dawirs et al., 1994), induces a significant delayed alternation impairment as well as significant increases in open-field motor activity and emotionality. Since an undisturbed development of the prefrontal DA-innervation seems to be a precondition for the maturation of normal PFC-related behaviours, a single early methamphetamine impact may be a suitable animal model for further investigation of structural and functional aspects of non-invasively induced behavioural deficits in rodents. The present results are discussed with regard to the assumption that hypofunctional mesoprefrontal DA-systems might be basic to schizophrenic behaviours in man.
Publishing Year
ISSN
eISSN
PUB-ID

Cite this

Dawirs RR, Teuchert-Noodt G, Czaniera R. Ontogeny of PFC-related behaviours is sensitive to a single non-invasive dose of methamphetamine in neonatal gerbils (Meriones unguiculatus). J Neural Transm. 1996;103(11):1235-1245.
Dawirs, R. R., Teuchert-Noodt, G., & Czaniera, R. (1996). Ontogeny of PFC-related behaviours is sensitive to a single non-invasive dose of methamphetamine in neonatal gerbils (Meriones unguiculatus). J Neural Transm, 103(11), 1235-1245.
Dawirs, R. R., Teuchert-Noodt, G., and Czaniera, R. (1996). Ontogeny of PFC-related behaviours is sensitive to a single non-invasive dose of methamphetamine in neonatal gerbils (Meriones unguiculatus). J Neural Transm 103, 1235-1245.
Dawirs, R.R., Teuchert-Noodt, G., & Czaniera, R., 1996. Ontogeny of PFC-related behaviours is sensitive to a single non-invasive dose of methamphetamine in neonatal gerbils (Meriones unguiculatus). J Neural Transm, 103(11), p 1235-1245.
R.R. Dawirs, G. Teuchert-Noodt, and R. Czaniera, “Ontogeny of PFC-related behaviours is sensitive to a single non-invasive dose of methamphetamine in neonatal gerbils (Meriones unguiculatus).”, J Neural Transm, vol. 103, 1996, pp. 1235-1245.
Dawirs, R.R., Teuchert-Noodt, G., Czaniera, R.: Ontogeny of PFC-related behaviours is sensitive to a single non-invasive dose of methamphetamine in neonatal gerbils (Meriones unguiculatus). J Neural Transm. 103, 1235-1245 (1996).
Dawirs, R R, Teuchert-Noodt, Gertraud, and Czaniera, R. “Ontogeny of PFC-related behaviours is sensitive to a single non-invasive dose of methamphetamine in neonatal gerbils (Meriones unguiculatus).”. J Neural Transm 103.11 (1996): 1235-1245.
This data publication is cited in the following publications:
This publication cites the following data publications:

13 Citations in Europe PMC

Data provided by Europe PubMed Central.

Effect of postnatal methamphetamine trauma and adolescent methylphenidate treatment on adult hippocampal neurogenesis in gerbils.
Schaefers AT, Teuchert-Noodt G, Bagorda F, Brummelte S., Eur. J. Pharmacol. 616(1-3), 2009
PMID: 19540225
Activity-dependent structural plasticity.
Butz M, Worgotter F, van Ooyen A., Brain Res Rev 60(2), 2009
PMID: 19162072
Alteration in the GABAergic network of the prefrontal cortex in a potential animal model of psychosis.
Brummelte S, Neddens J, Teuchert-Noodt G., J Neural Transm (Vienna) 114(5), 2007
PMID: 17195918
Contralateral prefrontal projections in gerbils mature abnormally after early methamphetamine trauma and isolated rearing.
Witte AV, Bagorda F, Teuchert-Noodt G, Lehmann K., J Neural Transm (Vienna) 114(2), 2007
PMID: 16715206
Influence of methylphenidate on brain development--an update of recent animal experiments.
Grund T, Lehmann K, Bock N, Rothenberger A, Teuchert-Noodt G., Behav Brain Funct 2(), 2006
PMID: 16403217
Postnatal maturation of cortical serotonin lateral asymmetry in gerbils is vulnerable to both environmental and pharmacological epigenetic challenges.
Neddens J, Dawirs RR, Bagorda F, Busche A, Horstmann S, Teuchert-Noodt G., Brain Res. 1021(2), 2004
PMID: 15342268
Pharmacologically induced neural plasticity in the prefrontal cortex of adult gerbils (Meriones unguiculatus).
Dawirs RR, Teuchert-Noodt G, Nossoll M., Eur. J. Pharmacol. 327(2-3), 1997
PMID: 9200549

65 References

Data provided by Europe PubMed Central.

Lesion of dopaminergic terminals in the amygdala produces enhanced locomotor response to D-amphetamine and opposite changes in dopaminergic activity in prefrontal cortex and nucleus accumbens.
Simon H, Taghzouti K, Gozlan H, Studler JM, Louilot A, Herve D, Glowinski J, Tassin JP, Le Moal M., Brain Res. 447(2), 1988
PMID: 3134111
Influence of the mesocortical dopaminergic system on activity, food hoarding, social-agonistic behavior, and spatial delayed alternation in male rats.
Stam CJ, de Bruin JP, van Haelst AM, van der Gugten J, Kalsbeek A., Behav. Neurosci. 103(1), 1989
PMID: 2923675
Behavioural deficits induced by an electrolytic lesion of the rat ventral mesencephalic tegmentum are corrected by a superimposed lesion of the dorsal noradrenergic system.
Taghzouti K, Simon H, Herve D, Blanc G, Studler JM, Glowinski J, LeMoal M, Tassin JP., Brain Res. 440(1), 1988
PMID: 3129124
Relationship between the locomotor hyperactivity induced by A10 lesions and the destruction of the fronto-cortical dopaminergic innervation in the rat.
Tassin JP, Stinus L, Simon H, Blanc G, Thierry AM, Le Moal M, Cardo B, Glowinski J., Brain Res. 141(2), 1978
PMID: 626903
Influence of the ascending monoaminergic systems on the activity of the rat prefrontal cortex.
Thierry AM, Godbout R, Mantz J, Glowinski J., Prog. Brain Res. 85(), 1990
PMID: 2094905
Delayed response tasks and prefrontal lesions in man--evidence for self generated patterns of behaviour with poor environmental modulation.
Verin M, Partiot A, Pillon B, Malapani C, Agid Y, Dubois B., Neuropsychologia 31(12), 1993
PMID: 8127434
Role of residual anterior neocortex in recovery from neonatal prefrontal lesions in the rat.
Vicedomini JP, Corwin JV, Nonneman AJ., Physiol. Behav. 28(5), 1982
PMID: 7100281
Role of the caudate nucleus in recovery from neonatal mediofrontal cortex lesions in the rat.
Vicedomini JP, Isaac WL, Nonneman AJ., Dev Psychobiol 17(1), 1984
PMID: 6698311
Prenatal stress selectively alters the reactivity of the hypothalamic-pituitary adrenal system in the female rat.
Weinstock M, Matlina E, Maor GI, Rosen H, McEwen BS., Brain Res. 595(2), 1992
PMID: 1467966

N, Arch Geront Geriat 8(), 1989

Export

0 Marked Publications

Open Data PUB

Web of Science

View record in Web of Science®

Sources

PMID: 9013410
PubMed | Europe PMC

Search this title in

Google Scholar