Dopamine and the regulation of cell proliferation in gerbil (Meriones unguiculatus) pyloric mucosa.

Wegner C, Dawirs RR, Grond C, Teuchert-Noodt G (1997)
Life Sci 60(22): 2005-2011.

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Zeitschriftenaufsatz | Veröffentlicht | Englisch
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Abstract / Bemerkung
The epithelium of the digestive system mucosa consists of a highly dynamic cell population. The conditions under which mitotic activity in the gastrointestinal epithelium is regulated is as yet poorly understood. Nevertheless, it is assumed that some biogenic amines might be involved. Having demonstrated that dopaminergic cells occur in the stomach of gerbils (Meriones unguiculatus), in the present study we examined the influence of dopamine antagonist haloperidol on the proliferation of epithelial cells in the mucosa of the stomach. Proliferating cells were detected immunocytochemically and quantified after in-vivo labeling with 5-bromo-2'-desoxyuridine in both haloperidol- and saline-treated animals. The results show that acute doses of haloperidol significantly increases the proliferation rate in the pyloric mucosa, suggesting that dopamine plays a probable modulatory role in the regulation of mitotic activity. These findings are discussed with regard to the role of paraneurons in regulating epithelial mitosis.
Erscheinungsjahr
Zeitschriftentitel
Life Sci
Band
60
Zeitschriftennummer
22
Seite
2005-2011
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Wegner C, Dawirs RR, Grond C, Teuchert-Noodt G. Dopamine and the regulation of cell proliferation in gerbil (Meriones unguiculatus) pyloric mucosa. Life Sci. 1997;60(22):2005-2011.
Wegner, C., Dawirs, R. R., Grond, C., & Teuchert-Noodt, G. (1997). Dopamine and the regulation of cell proliferation in gerbil (Meriones unguiculatus) pyloric mucosa. Life Sci, 60(22), 2005-2011. doi:10.1016/S0024-3205(97)00165-3
Wegner, C., Dawirs, R. R., Grond, C., and Teuchert-Noodt, G. (1997). Dopamine and the regulation of cell proliferation in gerbil (Meriones unguiculatus) pyloric mucosa. Life Sci 60, 2005-2011.
Wegner, C., et al., 1997. Dopamine and the regulation of cell proliferation in gerbil (Meriones unguiculatus) pyloric mucosa. Life Sci, 60(22), p 2005-2011.
C. Wegner, et al., “Dopamine and the regulation of cell proliferation in gerbil (Meriones unguiculatus) pyloric mucosa.”, Life Sci, vol. 60, 1997, pp. 2005-2011.
Wegner, C., Dawirs, R.R., Grond, C., Teuchert-Noodt, G.: Dopamine and the regulation of cell proliferation in gerbil (Meriones unguiculatus) pyloric mucosa. Life Sci. 60, 2005-2011 (1997).
Wegner, Claas, Dawirs, R R, Grond, C, and Teuchert-Noodt, Gertraud. “Dopamine and the regulation of cell proliferation in gerbil (Meriones unguiculatus) pyloric mucosa.”. Life Sci 60.22 (1997): 2005-2011.

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