Pharmacologically induced neural plasticity in the prefrontal cortex of adult gerbils (Meriones unguiculatus).

Dawirs RR, Teuchert-Noodt G, Nossoll M (1997)
Eur J Pharmacol 327(2-3): 117-123.

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Abstract
Using a selective antibody serum against glutaraldehyde-conjugated gamma-aminobutyric acid (GABA), GABAergic neurons were identified in the medial prefrontal cortex of young adult gerbils (Meriones unguiculatus) following a single non-invasive dose of methamphetamine (25 mg/kg i.p.) applied at the age of 90 days. GABA-immunoreactive profiles were electron microscopically counted in a defined test field (0.875 mm2) covering the prefrontal prelimbic area after a single dose of either methamphetamine or saline. Within 30 days following the drug challenge the density of GABAergic innervation significantly increased by about 20%. Several lines of previous investigation indicate that a single dose of methamphetamine is an appropriate stimulus to cause selective autotoxic destruction of certain prefrontal dopamine fibres due to drug-induced hyperactivation. There is further indication of postsynaptic and transneuronal neuroplasticity since the densities of dendritic spines on prefrontal pyramidal cells went through a significant sequence of post-drug gain and loss. These structural dynamics resemble typical alterations seen after classical mechanical or chemical lesioning in other regions of the brain. The present results on drug-induced reactive neuroplasticity are discussed together with the current understanding of stimulus-induced adaptive reorganization in the mammalian central nervous system.
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Dawirs RR, Teuchert-Noodt G, Nossoll M. Pharmacologically induced neural plasticity in the prefrontal cortex of adult gerbils (Meriones unguiculatus). Eur J Pharmacol. 1997;327(2-3):117-123.
Dawirs, R. R., Teuchert-Noodt, G., & Nossoll, M. (1997). Pharmacologically induced neural plasticity in the prefrontal cortex of adult gerbils (Meriones unguiculatus). Eur J Pharmacol, 327(2-3), 117-123.
Dawirs, R. R., Teuchert-Noodt, G., and Nossoll, M. (1997). Pharmacologically induced neural plasticity in the prefrontal cortex of adult gerbils (Meriones unguiculatus). Eur J Pharmacol 327, 117-123.
Dawirs, R.R., Teuchert-Noodt, G., & Nossoll, M., 1997. Pharmacologically induced neural plasticity in the prefrontal cortex of adult gerbils (Meriones unguiculatus). Eur J Pharmacol, 327(2-3), p 117-123.
R.R. Dawirs, G. Teuchert-Noodt, and M. Nossoll, “Pharmacologically induced neural plasticity in the prefrontal cortex of adult gerbils (Meriones unguiculatus).”, Eur J Pharmacol, vol. 327, 1997, pp. 117-123.
Dawirs, R.R., Teuchert-Noodt, G., Nossoll, M.: Pharmacologically induced neural plasticity in the prefrontal cortex of adult gerbils (Meriones unguiculatus). Eur J Pharmacol. 327, 117-123 (1997).
Dawirs, R R, Teuchert-Noodt, Gertraud, and Nossoll, M. “Pharmacologically induced neural plasticity in the prefrontal cortex of adult gerbils (Meriones unguiculatus).”. Eur J Pharmacol 327.2-3 (1997): 117-123.
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31 References

Data provided by Europe PubMed Central.

Influence of the mesocortical dopaminergic system on activity, food hoarding, social-agonistic behavior, and spatial delayed alternation in male rats.
Stam CJ, de Bruin JP, van Haelst AM, van der Gugten J, Kalsbeek A., Behav. Neurosci. 103(1), 1989
PMID: 2923675
Antibodies against gamma-aminobutyric acid: specificity studies and immunocytochemical results.
Seguela P, Geffard M, Buijs RM, Le Moal M., Proc. Natl. Acad. Sci. U.S.A. 81(12), 1984
PMID: 6587397
Cell biology of synaptic plasticity.
Cotman CW, Nieto-Sampedro M., Science 225(4668), 1984
PMID: 6382610

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