Pharmacologically induced neural plasticity in the prefrontal cortex of adult gerbils (Meriones unguiculatus).

Dawirs RR, Teuchert-Noodt G, Nossoll M (1997)
Eur J Pharmacol 327(2-3): 117-123.

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Zeitschriftenaufsatz | Veröffentlicht | Englisch
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Abstract / Bemerkung
Using a selective antibody serum against glutaraldehyde-conjugated gamma-aminobutyric acid (GABA), GABAergic neurons were identified in the medial prefrontal cortex of young adult gerbils (Meriones unguiculatus) following a single non-invasive dose of methamphetamine (25 mg/kg i.p.) applied at the age of 90 days. GABA-immunoreactive profiles were electron microscopically counted in a defined test field (0.875 mm2) covering the prefrontal prelimbic area after a single dose of either methamphetamine or saline. Within 30 days following the drug challenge the density of GABAergic innervation significantly increased by about 20%. Several lines of previous investigation indicate that a single dose of methamphetamine is an appropriate stimulus to cause selective autotoxic destruction of certain prefrontal dopamine fibres due to drug-induced hyperactivation. There is further indication of postsynaptic and transneuronal neuroplasticity since the densities of dendritic spines on prefrontal pyramidal cells went through a significant sequence of post-drug gain and loss. These structural dynamics resemble typical alterations seen after classical mechanical or chemical lesioning in other regions of the brain. The present results on drug-induced reactive neuroplasticity are discussed together with the current understanding of stimulus-induced adaptive reorganization in the mammalian central nervous system.
Erscheinungsjahr
Zeitschriftentitel
Eur J Pharmacol
Band
327
Zeitschriftennummer
2-3
Seite
117-123
ISSN
PUB-ID

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Dawirs RR, Teuchert-Noodt G, Nossoll M. Pharmacologically induced neural plasticity in the prefrontal cortex of adult gerbils (Meriones unguiculatus). Eur J Pharmacol. 1997;327(2-3):117-123.
Dawirs, R. R., Teuchert-Noodt, G., & Nossoll, M. (1997). Pharmacologically induced neural plasticity in the prefrontal cortex of adult gerbils (Meriones unguiculatus). Eur J Pharmacol, 327(2-3), 117-123. doi:10.1016/S0014-2999(97)89650-1
Dawirs, R. R., Teuchert-Noodt, G., and Nossoll, M. (1997). Pharmacologically induced neural plasticity in the prefrontal cortex of adult gerbils (Meriones unguiculatus). Eur J Pharmacol 327, 117-123.
Dawirs, R.R., Teuchert-Noodt, G., & Nossoll, M., 1997. Pharmacologically induced neural plasticity in the prefrontal cortex of adult gerbils (Meriones unguiculatus). Eur J Pharmacol, 327(2-3), p 117-123.
R.R. Dawirs, G. Teuchert-Noodt, and M. Nossoll, “Pharmacologically induced neural plasticity in the prefrontal cortex of adult gerbils (Meriones unguiculatus).”, Eur J Pharmacol, vol. 327, 1997, pp. 117-123.
Dawirs, R.R., Teuchert-Noodt, G., Nossoll, M.: Pharmacologically induced neural plasticity in the prefrontal cortex of adult gerbils (Meriones unguiculatus). Eur J Pharmacol. 327, 117-123 (1997).
Dawirs, R R, Teuchert-Noodt, Gertraud, and Nossoll, M. “Pharmacologically induced neural plasticity in the prefrontal cortex of adult gerbils (Meriones unguiculatus).”. Eur J Pharmacol 327.2-3 (1997): 117-123.

8 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Plasticity in the prefrontal cortex of adult rats.
Kolb B, Gibb R., Front Cell Neurosci 9(), 2015
PMID: 25691857
Activity-dependent structural plasticity.
Butz M, Wörgötter F, van Ooyen A., Brain Res Rev 60(2), 2009
PMID: 19162072
Long-term effects of a single adult methamphetamine challenge: minor impact on dopamine fibre density in limbic brain areas of gerbils.
Brummelte S, Grund T, Czok A, Teuchert-Noodt G, Neddens J., Behav Brain Funct 2(), 2006
PMID: 16569246
Functional recovery after central infusion of alpha-melanocyte-stimulating hormone in rats with spinal cord contusion injury.
Lankhorst AJ, Duis SE, ter Laak MP, Joosten EA, Hamers FP, Gispen WH., J Neurotrauma 16(4), 1999
PMID: 10225218

39 References

Daten bereitgestellt von Europe PubMed Central.

Contributions of dendritic spines and perforated synapses to synaptic plasticity.
Calverley RK, Jones DG., Brain Res. Brain Res. Rev. 15(3), 1990
PMID: 2289086
A stain for ischaemic or excessively stimulated neurons.
Clarke PG, Nussbaumer JC., Neuroscience 23(3), 1987
PMID: 2449640
Cell biology of synaptic plasticity.
Cotman CW, Nieto-Sampedro M., Science 225(4668), 1984
PMID: 6382610
Self-stabilization of neuronal networks. I. The compensation algorithm for synaptogenesis.
Dammasch IE, Wagner GP, Wolff JR., Biol Cybern 54(4-5), 1986
PMID: 3017460
The postnatal maturation of dopamine innervation in the prefrontal cortex of gerbils (Meriones unguiculatus) is sensitive to an early single dose of methamphetamine. A quantitative immunocytochemical study
Dawirs, J. Brain Res. 35(), 1994
The influence of neuronal activity on patterns of synaptic connections
Frank, Trends Neurosci. 10(), 1987
Golgi-like demonstration of "dark" neurons with an argyrophil III method for experimental neuropathology.
Gallyas F, Guldner FH, Zoltay G, Wolff JR., Acta Neuropathol. 79(6), 1990
PMID: 1694382
Immunohistochemical demonstration of plasticity in GABA neurons of the adult rat dentate gyrus.
Goldowitz D, Vincent SR, Wu JY, Hokfelt T., Brain Res. 238(2), 1982
PMID: 7046874

AUTHOR UNKNOWN, 0

AUTHOR UNKNOWN, 0
Neurotransmitters in the regulation of neuronal architecture
Mattson, Brain Res. Rev. 13(), 1988

AUTHOR UNKNOWN, 0
Hippocampal plasticity in the kindling model of epilepsy in rats.
Represa A, Le Gall La Salle G, Ben-Ari Y., Neurosci. Lett. 99(3), 1989
PMID: 2542847
Dopamine nerve terminal degeneration produced by high doses of methylamphetamine in the rat brain.
Ricaurte GA, Guillery RW, Seiden LS, Schuster CR, Moore RY., Brain Res. 235(1), 1982
PMID: 6145488

AUTHOR UNKNOWN, 0
Antibodies against gamma-aminobutyric acid: specificity studies and immunocytochemical results.
Seguela P, Geffard M, Buijs RM, Le Moal M., Proc. Natl. Acad. Sci. U.S.A. 81(12), 1984
PMID: 6587397

AUTHOR UNKNOWN, 0

AUTHOR UNKNOWN, 0
Influence of the mesocortical dopaminergic system on activity, food hoarding, social-agonistic behavior, and spatial delayed alternation in male rats.
Stam CJ, de Bruin JP, van Haelst AM, van der Gugten J, Kalsbeek A., Behav. Neurosci. 103(1), 1989
PMID: 2923675

AUTHOR UNKNOWN, 0
First visualization of glutamate and GABA in neurones by immunocytochemistry.
Storm-Mathisen J, Leknes AK, Bore AT, Vaaland JL, Edminson P, Haug FM, Ottersen OP., Nature 301(5900), 1983
PMID: 6130475
Naturally occuring synapse degeneration in the developing cerebellum of the Mallard (Anas platyrhynchos) and Peking duck (Forma domestica)
Teuchert-Noodt, J. Brain Res. 37(), 1996

AUTHOR UNKNOWN, 0

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