Neuronal degeneration and reorganization: a mutual principle in pathological and in healthy interactions of limbic and prefrontal circuits.

Teuchert-Noodt G (2000)
J Neural Transm Suppl (60).

Download
Es wurde kein Volltext hochgeladen. Nur Publikationsnachweis!
Zeitschriftenaufsatz | Veröffentlicht | Englisch
Abstract / Bemerkung
Based on developmental principles and insights from animal research about neuroplasticity in cell assemblies, this article is to propose a view of plasticity that promotes a link between hippocampal and prefrontal structure and function. Both the mitotic activity (counting of BrdU-labeled cells) in hippocampal dentatus and the maturation of dopamine fibres (quantitative immunochemistry of mesoprefrontal projection) in the prefrontal cortex proved to be a measurable combination for investigating the complex chain of events that relate activity dependent neuroplasticity to normal as well as to pathological maturational processes. With our animal model we demonstrate that both rearing conditions and neuroactive substances can effectively interfere with developmental plasticity and induce a malfunctional adaptation of prefrontal structures and neurotransmitter systems (dopamine, GABA). In the hippocampal dentatus, where ontogenetic plasticity proved to be preserved by continued neuro- and synaptogenesis, serious damage can be internalized without simultaneous disruption of neural dynamics offering an approach to reverse dysfunctional reorganization in the prefrontal cortex.
Erscheinungsjahr
Zeitschriftentitel
J Neural Transm Suppl
Zeitschriftennummer
60
ISSN
PUB-ID

Zitieren

Teuchert-Noodt G. Neuronal degeneration and reorganization: a mutual principle in pathological and in healthy interactions of limbic and prefrontal circuits. J Neural Transm Suppl. 2000;(60).
Teuchert-Noodt, G. (2000). Neuronal degeneration and reorganization: a mutual principle in pathological and in healthy interactions of limbic and prefrontal circuits. J Neural Transm Suppl(60)
Teuchert-Noodt, G. (2000). Neuronal degeneration and reorganization: a mutual principle in pathological and in healthy interactions of limbic and prefrontal circuits. J Neural Transm Suppl.
Teuchert-Noodt, G., 2000. Neuronal degeneration and reorganization: a mutual principle in pathological and in healthy interactions of limbic and prefrontal circuits. J Neural Transm Suppl, (60).
G. Teuchert-Noodt, “Neuronal degeneration and reorganization: a mutual principle in pathological and in healthy interactions of limbic and prefrontal circuits.”, J Neural Transm Suppl, 2000.
Teuchert-Noodt, G.: Neuronal degeneration and reorganization: a mutual principle in pathological and in healthy interactions of limbic and prefrontal circuits. J Neural Transm Suppl. (2000).
Teuchert-Noodt, Gertraud. “Neuronal degeneration and reorganization: a mutual principle in pathological and in healthy interactions of limbic and prefrontal circuits.”. J Neural Transm Suppl 60 (2000).

4 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Density of dopaminergic fibres in the prefrontal cortex of gerbils is sensitive to aging.
Brummelte S, Teuchert-Noodt G., Behav Brain Funct 3(), 2007
PMID: 17352812
Influence of methylphenidate on brain development--an update of recent animal experiments.
Grund T, Lehmann K, Bock N, Rothenberger A, Teuchert-Noodt G., Behav Brain Funct 2(), 2006
PMID: 16403217
Long-term effects of a single adult methamphetamine challenge: minor impact on dopamine fibre density in limbic brain areas of gerbils.
Brummelte S, Grund T, Czok A, Teuchert-Noodt G, Neddens J., Behav Brain Funct 2(), 2006
PMID: 16569246

Export

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Quellen

PMID: 11205150
PubMed | Europe PMC

Suchen in

Google Scholar