Influence of methylphenidate on brain development--an update of recent animal experiments.

Grund T, Lehmann K, Bock N, Rothenberger A, Teuchert-Noodt G (2006)
Behav Brain Funct 2(1).

Download
OA
Journal Article | Published | English
Author
; ; ; ;
Abstract
Methylphenidate (MPH) is the most commonly used drug to treat attention deficit/hyperactivity disorder (ADHD) in children effectively and safely. In spite of its widespread application throughout one of the most plastic and sensitive phases of brain development, very little is known to date about its long-term effects on brain structure and function. Hence, this short review updates the influence of MPH on brain development, since recent human and animal studies suggest that MPH alters the dopaminergic system with long-term effects beyond the termination of treatment.Animal studies imply that the effects of MPH may depend on the neural responder system: Whereas structural and functional parameters are improved by MPH in animals with psychomotor impairments, they remain unaltered or get worse in healthy controls. While recent behavioural studies do not fully support such a differential effect of MPH in ADHD, the animal studies certainly prompt for further investigation of this issue. Furthermore, the abuse of MPH, when (rarely) intravenously applied, may even impair the maturation of dopaminergic fibres in subcortical brain areas. This argues for careful clinical assessment and diagnostics of ADHD symptomatology not only in conjunction with the prescription of MPH. Hence, one should be assured that MPH is only given to children with clear ADHD symptomatology leading to psychosocial impairment. The animal data suggest that under these conditions MPH is supportive for brain development and the related behaviour in children with ADHD.
Publishing Year
ISSN
PUB-ID

Cite this

Grund T, Lehmann K, Bock N, Rothenberger A, Teuchert-Noodt G. Influence of methylphenidate on brain development--an update of recent animal experiments. Behav Brain Funct. 2006;2(1).
Grund, T., Lehmann, K., Bock, N., Rothenberger, A., & Teuchert-Noodt, G. (2006). Influence of methylphenidate on brain development--an update of recent animal experiments. Behav Brain Funct, 2(1).
Grund, T., Lehmann, K., Bock, N., Rothenberger, A., and Teuchert-Noodt, G. (2006). Influence of methylphenidate on brain development--an update of recent animal experiments. Behav Brain Funct 2.
Grund, T., et al., 2006. Influence of methylphenidate on brain development--an update of recent animal experiments. Behav Brain Funct, 2(1).
T. Grund, et al., “Influence of methylphenidate on brain development--an update of recent animal experiments.”, Behav Brain Funct, vol. 2, 2006.
Grund, T., Lehmann, K., Bock, N., Rothenberger, A., Teuchert-Noodt, G.: Influence of methylphenidate on brain development--an update of recent animal experiments. Behav Brain Funct. 2, (2006).
Grund, Thorsten, Lehmann, Konrad, Bock, Nathalie, Rothenberger, Aribert, and Teuchert-Noodt, Gertraud. “Influence of methylphenidate on brain development--an update of recent animal experiments.”. Behav Brain Funct 2.1 (2006).
Main File(s)
Access Level
OA Open Access

This data publication is cited in the following publications:
This publication cites the following data publications:

30 Citations in Europe PMC

Data provided by Europe PubMed Central.

From Clinical Application to Cognitive Enhancement: The Example of Methylphenidate.
Busardo FP, Kyriakou C, Cipolloni L, Zaami S, Frati P., Curr Neuropharmacol 14(1), 2016
PMID: 26813119
Adolescent exposure to methylphenidate impairs serial pattern learning in the serial multiple choice (SMC) task in adult rats.
Rowan JD, McCarty MK, Kundey SM, Osburn CD, Renaud SM, Kelley BM, Matoushek AW, Fountain SB., Neurotoxicol Teratol 51(), 2015
PMID: 26225921
A pharmacokinetic model of oral methylphenidate in the rat and effects on behavior.
Thanos PK, Robison LS, Steier J, Hwang YF, Cooper T, Swanson JM, Komatsu DE, Hadjiargyrou M, Volkow ND., Pharmacol. Biochem. Behav. 131(), 2015
PMID: 25641666
The effects of Psychotropic drugs On Developing brain (ePOD) study: methods and design.
Bottelier MA, Schouw ML, Klomp A, Tamminga HG, Schrantee AG, Bouziane C, de Ruiter MB, Boer F, Ruhe HG, Denys D, Rijsman R, Lindauer RJ, Reitsma HB, Geurts HM, Reneman L., BMC Psychiatry 14(), 2014
PMID: 24552282
Withdrawal effect of chronic amphetamine exposure during adolescence on complex maze performance.
Krall DM, Lim SL, Cooper AM, Burleson PW, Rhoades DJ, Jacquemin SJ, Willmore DC, Spears FM, Willmore CB., Addict Biol 19(4), 2014
PMID: 23374198

120 References

Data provided by Europe PubMed Central.

Methylphenidate treatment during pre- and periadolescence alters behavioral responses to emotional stimuli at adulthood.
Bolanos CA, Barrot M, Berton O, Wallace-Black D, Nestler EJ., Biol. Psychiatry 54(12), 2003
PMID: 14675795
Pharmacotherapy of attention-deficit/hyperactivity disorder reduces risk for substance use disorder
Biederman J, Wilens T, Mick E, Spencer T, Faraone SV., 1999
Adolescent exposure to methylphenidate alters the activity of rat midbrain dopamine neurons.
Brandon CL, Marinelli M, White FJ., Biol. Psychiatry 54(12), 2003
PMID: 14675797
Dynamic changes in sensitivity occur during the acute response to cocaine and methylphenidate.
Kuczenski R, Segal DS., Psychopharmacology (Berl.) 147(1), 1999
PMID: 10591874
Comparison between intraperitoneal and oral methylphenidate administration: A microdialysis and locomotor activity study.
Gerasimov MR, Franceschi M, Volkow ND, Gifford A, Gatley SJ, Marsteller D, Molina PE, Dewey SL., J. Pharmacol. Exp. Ther. 295(1), 2000
PMID: 10991960
Age-associated changes in the densities of presynaptic monoamine transporters in different regions of the rat brain from early juvenile life to late adulthood.
Moll GH, Mehnert C, Wicker M, Bock N, Rothenberger A, Ruther E, Huether G., Brain Res. Dev. Brain Res. 119(2), 2000
PMID: 10675775
Serum and brain concentrations of methylphenidate: implications for use and abuse.
Swanson JM, Volkow ND., Neurosci Biobehav Rev 27(7), 2003
PMID: 14624806
Metabolism and disposition of methylphenidate-14C: studies in man and animals.
Faraj BA, Israili ZH, Perel JM, Jenkins ML, Holtzman SG, Cucinell SA, Dayton PG., J. Pharmacol. Exp. Ther. 191(3), 1974
PMID: 4473537
Relapse to drug-seeking: neural and molecular mechanisms.
Self DW, Nestler EJ., Drug Alcohol Depend 51(1-2), 1998
PMID: 9716929
Stimulant treatment over five years: adherence, effectiveness, and adverse effects.
Charach A, Ickowicz A, Schachar R., J Am Acad Child Adolesc Psychiatry 43(5), 2004
PMID: 15100562
Altered neural substrates of cognitive control in childhood ADHD: evidence from functional magnetic resonance imaging.
Vaidya CJ, Bunge SA, Dudukovic NM, Zalecki CA, Elliott GR, Gabrieli JD., Am J Psychiatry 162(9), 2005
PMID: 16135618

Export

0 Marked Publications

Open Data PUB

Sources

PMID: 16403217
PubMed | Europe PMC

Search this title in

Google Scholar