The maturation of the acetylcholine system in the dentate gyrus of gerbils (Meriones unguiculatus) is affected by epigenetic factors.

Busche A, Bagorda A, Lehmann K, Neddens J, Teuchert-Noodt G (2006)
J Neural Transm 113(2): 113-124.

Journal Article | Published | English

No fulltext has been uploaded

Author
; ; ; ;
Abstract
The current study investigated the influence of impoverished rearing (IR) conditions and a single early methamphetamine challenge (MA; 50 mg/kg i.p.) on day 14 on the postnatal maturation of acetylcholinesterase-positive (AChE+) fibres in the hippocampal dentate gyrus (DG) of gerbils (Meriones unguiculatus). The layer-specific densities of histochemically stained AChE+ fibres were quantified in two planes of the left and right DG in young adults (day 90). Compared to enriched reared (ER) animals, the AChE+ fibre densities turned out to be higher in both the septal and the temporal plane of both hemispheres in saline treated IR and MA treated ER gerbils. The temporal plane was slightly more affected than the septal plane. In IR animals, MA treatment selectively diminished the AChE+ fibre densities in the subgranular layer of both left and right temporal DG. In conclusion, the maturation of AChE+ fibres is vulnerable to both rearing conditions and early MA challenge. The results correlate with our previous studies on the dentate cell proliferation rates and the serotonergic innervation, two parameters which are similarly affected by the experimental design. Thus, disturbances of the ACh system may impair the hippocampal plasticity and hippocampus-related cognitive and emotional function.
Publishing Year
ISSN
eISSN
PUB-ID

Cite this

Busche A, Bagorda A, Lehmann K, Neddens J, Teuchert-Noodt G. The maturation of the acetylcholine system in the dentate gyrus of gerbils (Meriones unguiculatus) is affected by epigenetic factors. J Neural Transm. 2006;113(2):113-124.
Busche, A., Bagorda, A., Lehmann, K., Neddens, J., & Teuchert-Noodt, G. (2006). The maturation of the acetylcholine system in the dentate gyrus of gerbils (Meriones unguiculatus) is affected by epigenetic factors. J Neural Transm, 113(2), 113-124.
Busche, A., Bagorda, A., Lehmann, K., Neddens, J., and Teuchert-Noodt, G. (2006). The maturation of the acetylcholine system in the dentate gyrus of gerbils (Meriones unguiculatus) is affected by epigenetic factors. J Neural Transm 113, 113-124.
Busche, A., et al., 2006. The maturation of the acetylcholine system in the dentate gyrus of gerbils (Meriones unguiculatus) is affected by epigenetic factors. J Neural Transm, 113(2), p 113-124.
A. Busche, et al., “The maturation of the acetylcholine system in the dentate gyrus of gerbils (Meriones unguiculatus) is affected by epigenetic factors.”, J Neural Transm, vol. 113, 2006, pp. 113-124.
Busche, A., Bagorda, A., Lehmann, K., Neddens, J., Teuchert-Noodt, G.: The maturation of the acetylcholine system in the dentate gyrus of gerbils (Meriones unguiculatus) is affected by epigenetic factors. J Neural Transm. 113, 113-124 (2006).
Busche, A, Bagorda, A, Lehmann, K, Neddens, J, and Teuchert-Noodt, Gertraud. “The maturation of the acetylcholine system in the dentate gyrus of gerbils (Meriones unguiculatus) is affected by epigenetic factors.”. J Neural Transm 113.2 (2006): 113-124.
This data publication is cited in the following publications:
This publication cites the following data publications:

4 Citations in Europe PMC

Data provided by Europe PubMed Central.

Choline status and neurodevelopmental outcomes at 5 years of age in the Seychelles Child Development Nutrition Study.
Strain JJ, McSorley EM, van Wijngaarden E, Kobrosly RW, Bonham MP, Mulhern MS, McAfee AJ, Davidson PW, Shamlaye CF, Henderson J, Watson GE, Thurston SW, Wallace JM, Ueland PM, Myers GJ., Br. J. Nutr. 110(2), 2013
PMID: 23298754
Activity-dependent structural plasticity.
Butz M, Worgotter F, van Ooyen A., Brain Res Rev 60(2), 2009
PMID: 19162072

Export

0 Marked Publications

Open Data PUB

Web of Science

View record in Web of Science®

Sources

PMID: 15959847
PubMed | Europe PMC

Search this title in

Google Scholar