NF-kappaB in the nervous system

Kaltschmidt B, Kaltschmidt C (2009)
Cold Spring Harbour Perspectives in Biology 1(3): a001271.

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Journal Article | Original Article | Published | English

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The transcription factor NF-kappaB has diverse functions in the nervous system, depending on the cellular context. NF-kappaB is constitutively activated in glutamatergic neurons. Knockout of p65 or inhibition of neuronal NF-kappaB by super-repressor IkappaB resulted in the loss of neuroprotection and defects in learning and memory. Similarly, p50-/- mice have a lower learning ability and are sensitive to neurotoxins. Activated NF-kappaB can be transported retrogradely from activated synapses to the nucleus to translate short-term processes to long-term changes such as axon growth, which is important for long-term memory. In glia, NF-kappaB is inducible and regulates inflammatory processes that exacerbate diseases such as autoimmune encephalomyelitis, ischemia, and Alzheimer's disease. In summary, inhibition of NF-kappaB in glia might ameliorate disease, whereas activation in neurons might enhance memory. This review focuses on results produced by the analysis of genetic models.
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Kaltschmidt B, Kaltschmidt C. NF-kappaB in the nervous system. Cold Spring Harbour Perspectives in Biology. 2009;1(3):a001271.
Kaltschmidt, B., & Kaltschmidt, C. (2009). NF-kappaB in the nervous system. Cold Spring Harbour Perspectives in Biology, 1(3), a001271. doi:10.1101/cshperspect.a001271
Kaltschmidt, B., and Kaltschmidt, C. (2009). NF-kappaB in the nervous system. Cold Spring Harbour Perspectives in Biology 1, a001271.
Kaltschmidt, B., & Kaltschmidt, C., 2009. NF-kappaB in the nervous system. Cold Spring Harbour Perspectives in Biology, 1(3), p a001271.
B. Kaltschmidt and C. Kaltschmidt, “NF-kappaB in the nervous system”, Cold Spring Harbour Perspectives in Biology, vol. 1, 2009, pp. a001271.
Kaltschmidt, B., Kaltschmidt, C.: NF-kappaB in the nervous system. Cold Spring Harbour Perspectives in Biology. 1, a001271 (2009).
Kaltschmidt, Barbara, and Kaltschmidt, Christian. “NF-kappaB in the nervous system”. Cold Spring Harbour Perspectives in Biology 1.3 (2009): a001271.
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