RELEASE OF PROTEINASES FROM STIMULATED POLYMORPHONUCLEAR LEUKOCYTES - EVIDENCE FOR SUBCLASSES OF THE MAIN GRANULE TYPES AND THEIR ASSOCIATION WITH CYTOSKELETAL COMPONENTS

SCHETTLER A, THORN H, JOCKUSCH BM, Tschesche H (1991)
EUROPEAN JOURNAL OF BIOCHEMISTRY 197(1): 197-202.

Download
Es wurde kein Volltext hochgeladen. Nur Publikationsnachweis!
Zeitschriftenaufsatz | Veröffentlicht | Englisch
Autor
; ; ;
Abstract / Bemerkung
The secretion of matrix-degrading proteinases and protein components involved in the production of cytotoxic metabolites is an important step in the sequence of defense reactions executed by polymorphonuclear leukocytes (PMNL) in response to stimulation. In the present report, we have analyzed degranulation of PMNL stimulated either with soluble synthetic peptides fLeu-Phe (fMet, formylmethionyl), or fAhx-Leu-Phe-Ahx-Tyr-Phe (Ahx, aminohexyl) which trigger chemotaxis and degranulation, or with opsonized zymosan which induces phagocytosis. The release of elastase, myeloperoxidase and lactoferrin-containing granules was not at all or only slightly (< 6%) induced either by fAhx-Leu-Phe-Ahx-Tyr-Leu or by zymosan particles. In contrast, type-I collagenase and gelatinase were secreted in significant amounts after treatment with these agents. The disruption of microfilaments by cytochalasin B and subsequent stimulation of PMNL with the formyl-peptide led to the secretion of elastase, myeloperoxidase and lactoferrin, and enhanced the release of gelatinase. Disruption of microtubules by incubation with colcemid resulted in inhibition of fAhx-Leu-Phe-Ahx-Thyr-Leu and fAhx-Leu-Phe-Ahx-Tyr-Leu/cytochalasin-B-induced granule release. Furthermore, we found different patterns of enzyme distribution after fractionation by centrifugation: most (> 90%) type-I collagenase and gelastinase was measured in the supernatant whereas 60 - 90% of elastase, myeloperoxidase and lactoferrin had partitioned into the cytoskeleton-containing pellet. Our results suggest that the two main types of secretory vesicles identified in PMNL (specific and azurophilic granules) consist of subpopulations. The differential association of the various types of granules with cytoskeletal elements may serve to control their sequential discharge.
Erscheinungsjahr
Zeitschriftentitel
EUROPEAN JOURNAL OF BIOCHEMISTRY
Band
197
Zeitschriftennummer
1
Seite
197-202
ISSN
eISSN
PUB-ID

Zitieren

SCHETTLER A, THORN H, JOCKUSCH BM, Tschesche H. RELEASE OF PROTEINASES FROM STIMULATED POLYMORPHONUCLEAR LEUKOCYTES - EVIDENCE FOR SUBCLASSES OF THE MAIN GRANULE TYPES AND THEIR ASSOCIATION WITH CYTOSKELETAL COMPONENTS. EUROPEAN JOURNAL OF BIOCHEMISTRY. 1991;197(1):197-202.
SCHETTLER, A., THORN, H., JOCKUSCH, B. M., & Tschesche, H. (1991). RELEASE OF PROTEINASES FROM STIMULATED POLYMORPHONUCLEAR LEUKOCYTES - EVIDENCE FOR SUBCLASSES OF THE MAIN GRANULE TYPES AND THEIR ASSOCIATION WITH CYTOSKELETAL COMPONENTS. EUROPEAN JOURNAL OF BIOCHEMISTRY, 197(1), 197-202. doi:10.1111/j.1432-1033.1991.tb15899.x
SCHETTLER, A., THORN, H., JOCKUSCH, B. M., and Tschesche, H. (1991). RELEASE OF PROTEINASES FROM STIMULATED POLYMORPHONUCLEAR LEUKOCYTES - EVIDENCE FOR SUBCLASSES OF THE MAIN GRANULE TYPES AND THEIR ASSOCIATION WITH CYTOSKELETAL COMPONENTS. EUROPEAN JOURNAL OF BIOCHEMISTRY 197, 197-202.
SCHETTLER, A., et al., 1991. RELEASE OF PROTEINASES FROM STIMULATED POLYMORPHONUCLEAR LEUKOCYTES - EVIDENCE FOR SUBCLASSES OF THE MAIN GRANULE TYPES AND THEIR ASSOCIATION WITH CYTOSKELETAL COMPONENTS. EUROPEAN JOURNAL OF BIOCHEMISTRY, 197(1), p 197-202.
A. SCHETTLER, et al., “RELEASE OF PROTEINASES FROM STIMULATED POLYMORPHONUCLEAR LEUKOCYTES - EVIDENCE FOR SUBCLASSES OF THE MAIN GRANULE TYPES AND THEIR ASSOCIATION WITH CYTOSKELETAL COMPONENTS”, EUROPEAN JOURNAL OF BIOCHEMISTRY, vol. 197, 1991, pp. 197-202.
SCHETTLER, A., THORN, H., JOCKUSCH, B.M., Tschesche, H.: RELEASE OF PROTEINASES FROM STIMULATED POLYMORPHONUCLEAR LEUKOCYTES - EVIDENCE FOR SUBCLASSES OF THE MAIN GRANULE TYPES AND THEIR ASSOCIATION WITH CYTOSKELETAL COMPONENTS. EUROPEAN JOURNAL OF BIOCHEMISTRY. 197, 197-202 (1991).
SCHETTLER, A, THORN, H, JOCKUSCH, BM, and Tschesche, Harald. “RELEASE OF PROTEINASES FROM STIMULATED POLYMORPHONUCLEAR LEUKOCYTES - EVIDENCE FOR SUBCLASSES OF THE MAIN GRANULE TYPES AND THEIR ASSOCIATION WITH CYTOSKELETAL COMPONENTS”. EUROPEAN JOURNAL OF BIOCHEMISTRY 197.1 (1991): 197-202.

23 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Physiology and pathophysiology of matrix metalloproteases.
Klein T, Bischoff R., Amino Acids 41(2), 2011
PMID: 20640864
Are primed polymorphonuclear leukocytes contributors to the high heparanase levels in hemodialysis patients?
Cohen-Mazor M, Sela S, Mazor R, Ilan N, Vlodavsky I, Rops AL, van der Vlag J, Cohen HI, Kristal B., Am J Physiol Heart Circ Physiol 294(2), 2008
PMID: 18032524
The antenatal identification of funisitis with a rapid MMP-8 bedside test.
Park CW, Lee SM, Park JS, Jun JK, Romero R, Yoon BH., J Perinat Med 36(6), 2008
PMID: 19127606
The actin cytoskeleton regulates exocytosis of all neutrophil granule subsets.
Jog NR, Rane MJ, Lominadze G, Luerman GC, Ward RA, McLeish KR., Am J Physiol Cell Physiol 292(5), 2007
PMID: 17202227
Modulation of the proteolytic activity of matrix metalloproteinase-2 (gelatinase A) on fibrinogen.
Monaco S, Gioia M, Rodriguez J, Fasciglione GF, Di Pierro D, Lupidi G, Krippahl L, Marini S, Coletta M., Biochem J 402(3), 2007
PMID: 17087661
Granulocyte activation in humans is modulated by psychological stress and relaxation.
Keresztes M, Rudisch T, Tajti J, Ocsovszki I, Gardi J., Stress 10(3), 2007
PMID: 17613941
Elevated mid-trimester amniotic fluid ADAM-8 concentrations as a potential risk factor for preterm delivery.
Vrachnis N, Malamitsi-Puchner A, Samoli E, Botsis D, Iliodromiti Z, Baka S, Hassiakos D, Creatsas G., J Soc Gynecol Investig 13(3), 2006
PMID: 16638589
Possible early prediction of preterm birth by determination of novel proinflammatory factors in midtrimester amniotic fluid.
Malamitsi-Puchner A, Vrachnis N, Samoli E, Baka S, Iliodromiti Z, Puchner KP, Malligianis P, Hassiakos D., Ann N Y Acad Sci 1092(), 2006
PMID: 17308171
Amniotic fluid matrix metalloproteinase-8 and the development of cerebral palsy.
Moon JB, Kim JC, Yoon BH, Romero R, Kim G, Oh SY, Kim M, Shim SS., J Perinat Med 30(4), 2002
PMID: 12235718
The relationship between amniotic fluid matrix metalloproteinase-8 and funisitis.
Park JS, Romero R, Yoon BH, Moon JB, Oh SY, Han SY, Ko EM., Am J Obstet Gynecol 185(5), 2001
PMID: 11717650
Increase of lung neutrophils in hypersensitivity pneumonitis is associated with lung fibrosis.
Pardo A, Barrios R, Gaxiola M, Segura-Valdez L, Carrillo G, Estrada A, Mejía M, Selman M., Am J Respir Crit Care Med 161(5), 2000
PMID: 10806177
Human neutrophil collagenase (matrix metalloproteinase 8) in parturition, premature rupture of the membranes, and intrauterine infection.
Maymon E, Romero R, Pacora P, Gomez R, Athayde N, Edwin S, Yoon BH., Am J Obstet Gynecol 183(1), 2000
PMID: 10920315
The solution structure and dynamics of human neutrophil gelatinase-associated lipocalin.
Coles M, Diercks T, Muehlenweg B, Bartsch S, Zölzer V, Tschesche H, Kessler H., J Mol Biol 289(1), 1999
PMID: 10339412
Cellular responses to FMLP challenging: a mini-review.
Panaro MA, Mitolo V., Immunopharmacol Immunotoxicol 21(3), 1999
PMID: 10466071
Determination of metalloproteinases, plasminogen-activators and their inhibitors in the synovial fluids of patients with rheumatoid arthritis during chemical synoviorthesis.
Blaser J, Triebel S, Maasjosthusmann U, Romisch J, Krahl-Mateblowski U, Freudenberg W, Fricke R, Tschesche H., Clin Chim Acta 244(1), 1996
PMID: 8919199
Inhibition of degranulation of human polymorphonuclear leukocytes by complement factor D.
Balke N, Holtkamp U, Hörl WH, Tschesche H., FEBS Lett 371(3), 1995
PMID: 7556615
Oxygen-dependent modulation of release and activity of polymorphonuclear leukocyte granule products.
Claesson R, Johansson E, Carlsson J., Oral Microbiol Immunol 9(2), 1994
PMID: 8008434
Upregulation of human neutrophil CD59, a regulator of the membrane attack complex of complement, following cell activation.
Gordon DL, Papazaharoudakis H, Sadlon TA, Arellano A, Okada N., Immunol Cell Biol 72(3), 1994
PMID: 7522216
Interleukin-8 processing by neutrophil elastase, cathepsin G and proteinase-3.
Padrines M, Wolf M, Walz A, Baggiolini M., FEBS Lett 352(2), 1994
PMID: 7925979
Suppressive effects of hyaluronic acid on elastase release from rat peritoneal leucocytes.
Akatsuka M, Yamamoto Y, Tobetto K, Yasui T, Ando T., J Pharm Pharmacol 45(2), 1993
PMID: 8095524
Fragmentation of human polymorphonuclear-leucocyte collagenase.
Knäuper V, Osthues A, DeClerck YA, Langley KE, Bläser J, Tschesche H., Biochem J 291 ( Pt 3)(), 1993
PMID: 8489511

26 References

Daten bereitgestellt von Europe PubMed Central.

Export

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®

Quellen

PMID: 2015820
PubMed | Europe PMC

Suchen in

Google Scholar