Defect of sperm assembly in a neurological mutant of the mouse, wobbler (WR)

Heimann P, LAAGE S, Jockusch H (1991)
Differentiation 47(2): 77-83.

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Zeitschriftenaufsatz | Veröffentlicht | Englisch
Abstract / Bemerkung
In the wobbler (WR) mouse, a neuromuscular mutant characterized by a motoneuron degeneration and male infertility, the cellular basis of the defect in spermiogenesis was studied by light and electron microscopy as well as by lectin binding. Spermatozoa of the wobbler mutant had rounded heads, and their motility was reduced. In histological sections of WR testes, spermatogenesis appeared normal up to the stage of round spermatids, but the elongation and flattening of the nucleus during late spermiogenesis did not occur. Numbers of spermatid nuclei in WR testes were reduced to 70%-80% of controls. The acrosomal marker glycoprotein, peanut agglutinin receptor, was synthesized, but the acrosomal membrane did not attach to the nucleus. The disturbance in spermiogenesis of the wobbler mouse is not due to impaired descent of the testis, nor to a lack of testosterone, and is distinct from that observed in other mouse mutants (quaking, QK; Purkinje cell degeneration, PCD) with combined neurological and spermiogenesis defects.
Erscheinungsjahr
Zeitschriftentitel
Differentiation
Band
47
Zeitschriftennummer
2
Seite
77-83
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eISSN
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Heimann P, LAAGE S, Jockusch H. Defect of sperm assembly in a neurological mutant of the mouse, wobbler (WR). Differentiation. 1991;47(2):77-83.
Heimann, P., LAAGE, S., & Jockusch, H. (1991). Defect of sperm assembly in a neurological mutant of the mouse, wobbler (WR). Differentiation, 47(2), 77-83. doi:10.1111/j.1432-0436.1991.tb00225.x
Heimann, P., LAAGE, S., and Jockusch, H. (1991). Defect of sperm assembly in a neurological mutant of the mouse, wobbler (WR). Differentiation 47, 77-83.
Heimann, P., LAAGE, S., & Jockusch, H., 1991. Defect of sperm assembly in a neurological mutant of the mouse, wobbler (WR). Differentiation, 47(2), p 77-83.
P. Heimann, S. LAAGE, and H. Jockusch, “Defect of sperm assembly in a neurological mutant of the mouse, wobbler (WR)”, Differentiation, vol. 47, 1991, pp. 77-83.
Heimann, P., LAAGE, S., Jockusch, H.: Defect of sperm assembly in a neurological mutant of the mouse, wobbler (WR). Differentiation. 47, 77-83 (1991).
Heimann, Peter, LAAGE, S, and Jockusch, Harald. “Defect of sperm assembly in a neurological mutant of the mouse, wobbler (WR)”. Differentiation 47.2 (1991): 77-83.

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