THE GENE FOR CILIARY NEUROTROPHIC FACTOR (CNTF) MAPS TO MURINE CHROMOSOME 19 AND ITS EXPRESSION IS NOT AFFECTED IN THE HEREDITARY MOTONEURON DISEASE WOBBLER OF THE MOUSE

KAUPMANN K, SENDTNER M, STOCKLI KA, Jockusch H (1991)
EUROPEAN JOURNAL OF NEUROSCIENCE 3(11): 1182-1186.

Journal Article | Published | English

No fulltext has been uploaded

Author
; ; ;
Abstract
The cDNA for ciliary neurotrophic factor (CNTF), a polypeptide involved in the survival of motoneurons in mammals, has recently been cloned (Stockli et al., Nature, 342, 920-923, 1989; Lin et al., Science, 246, 1023-1025, 1989). We have now localized the corresponding gene Cntf to chromosome 19 in the mouse, using an interspecific cross between Mus spretus and Mus musculus domesticus. The latter was carrying the gene wobbler (wr) for spinal muscular atrophy. DNA was prepared from backcross individuals and typed for the segregation of species-specific Cntf restriction fragments in relation to DNA markers of known chromosomal location. The M.spretus allele of Cntf cosegregated with chromosome 19 markers and mapped closely to Ly-1, to a region of mouse chromosome 19 with conserved synteny to human chromosome 11q. Cntf is not linked to wr, and the expression of CNTF mRNA and protein appears close to normal in facial and sciatic nerves of affected (wr/wr) mice, suggesting that motoneuron degeneration of wobbler mice has its origin in defects other than reduced CNTF expression.
Publishing Year
ISSN
eISSN
PUB-ID

Cite this

KAUPMANN K, SENDTNER M, STOCKLI KA, Jockusch H. THE GENE FOR CILIARY NEUROTROPHIC FACTOR (CNTF) MAPS TO MURINE CHROMOSOME 19 AND ITS EXPRESSION IS NOT AFFECTED IN THE HEREDITARY MOTONEURON DISEASE WOBBLER OF THE MOUSE. EUROPEAN JOURNAL OF NEUROSCIENCE. 1991;3(11):1182-1186.
KAUPMANN, K., SENDTNER, M., STOCKLI, K. A., & Jockusch, H. (1991). THE GENE FOR CILIARY NEUROTROPHIC FACTOR (CNTF) MAPS TO MURINE CHROMOSOME 19 AND ITS EXPRESSION IS NOT AFFECTED IN THE HEREDITARY MOTONEURON DISEASE WOBBLER OF THE MOUSE. EUROPEAN JOURNAL OF NEUROSCIENCE, 3(11), 1182-1186.
KAUPMANN, K., SENDTNER, M., STOCKLI, K. A., and Jockusch, H. (1991). THE GENE FOR CILIARY NEUROTROPHIC FACTOR (CNTF) MAPS TO MURINE CHROMOSOME 19 AND ITS EXPRESSION IS NOT AFFECTED IN THE HEREDITARY MOTONEURON DISEASE WOBBLER OF THE MOUSE. EUROPEAN JOURNAL OF NEUROSCIENCE 3, 1182-1186.
KAUPMANN, K., et al., 1991. THE GENE FOR CILIARY NEUROTROPHIC FACTOR (CNTF) MAPS TO MURINE CHROMOSOME 19 AND ITS EXPRESSION IS NOT AFFECTED IN THE HEREDITARY MOTONEURON DISEASE WOBBLER OF THE MOUSE. EUROPEAN JOURNAL OF NEUROSCIENCE, 3(11), p 1182-1186.
K. KAUPMANN, et al., “THE GENE FOR CILIARY NEUROTROPHIC FACTOR (CNTF) MAPS TO MURINE CHROMOSOME 19 AND ITS EXPRESSION IS NOT AFFECTED IN THE HEREDITARY MOTONEURON DISEASE WOBBLER OF THE MOUSE”, EUROPEAN JOURNAL OF NEUROSCIENCE, vol. 3, 1991, pp. 1182-1186.
KAUPMANN, K., SENDTNER, M., STOCKLI, K.A., Jockusch, H.: THE GENE FOR CILIARY NEUROTROPHIC FACTOR (CNTF) MAPS TO MURINE CHROMOSOME 19 AND ITS EXPRESSION IS NOT AFFECTED IN THE HEREDITARY MOTONEURON DISEASE WOBBLER OF THE MOUSE. EUROPEAN JOURNAL OF NEUROSCIENCE. 3, 1182-1186 (1991).
KAUPMANN, K, SENDTNER, M, STOCKLI, KA, and Jockusch, Harald. “THE GENE FOR CILIARY NEUROTROPHIC FACTOR (CNTF) MAPS TO MURINE CHROMOSOME 19 AND ITS EXPRESSION IS NOT AFFECTED IN THE HEREDITARY MOTONEURON DISEASE WOBBLER OF THE MOUSE”. EUROPEAN JOURNAL OF NEUROSCIENCE 3.11 (1991): 1182-1186.
This data publication is cited in the following publications:
This publication cites the following data publications:

11 Citations in Europe PMC

Data provided by Europe PubMed Central.

Reduced GABAergic inhibition explains cortical hyperexcitability in the wobbler mouse model of ALS.
Nieto-Gonzalez JL, Moser J, Lauritzen M, Schmitt-John T, Jensen K., Cereb. Cortex 21(3), 2011
PMID: 20643756
Neuromuscular degeneration (nmd): a mutation on mouse chromosome 19 that causes motor neuron degeneration.
Cook SA, Johnson KR, Bronson RT, Davisson MT., Mamm. Genome 6(3), 1995
PMID: 7749225
Ciliary neurotrophic factor.
Sendtner M, Carroll P, Holtmann B, Hughes RA, Thoenen H., J. Neurobiol. 25(11), 1994
PMID: 7852996
Actions of CNTF and neurotrophins on degenerating motoneurons: preclinical studies and clinical implications.
Sendtner M, Dittrich F, Hughes RA, Thoenen H., J. Neurol. Sci. 124 Suppl(), 1994
PMID: 7807152
Exploring the mammalian neuromuscular system by analysis of mutations: spinal muscular atrophy and myotonia.
Jockusch H, Kaupmann K, Gronemeier M, Schleef M, Klocke R., Prog. Neurobiol. 42(2), 1994
PMID: 8008830
Exclusion of two candidate genes, Spnb-2 and Dcd, for the wobbler spinal muscular atrophy gene on proximal mouse chromosome 11.
Lengeling A, Zimmer WE, Goodman SR, Ma Y, Bloom ML, Bruneau G, Krieger M, Thibault J, Kaupmann K, Jockusch H., Mamm. Genome 5(3), 1994
PMID: 8199405
Mouse chromosome 19.
Guenet JL, Watson M, Seldin MF., Mamm. Genome 3 Spec No(), 1992
PMID: 1498439
Wobbler, a mutation affecting motoneuron survival and gonadal functions in the mouse, maps to proximal chromosome 11.
Kaupmann K, Simon-Chazottes D, Guenet JL, Jockusch H., Genomics 13(1), 1992
PMID: 1349581

32 References

Data provided by Europe PubMed Central.

RNA molecular weight determinations by gel electrophoresis under denaturing conditions, a critical reexamination.
Lehrach H, Diamond D, Wozney JM, Boedtker H., Biochemistry 16(21), 1977
PMID: 911786
Genomic sequencing.
Church GM, Gilbert W., Proc. Natl. Acad. Sci. U.S.A. 81(7), 1984
PMID: 6326095
Purification of the chick eye ciliary neuronotrophic factor.
Barbin G, Manthorpe M, Varon S., J. Neurochem. 43(5), 1984
PMID: 6491662
Purification, cloning, and expression of ciliary neurotrophic factor (CNTF).
Lin LF, Mismer D, Lile JD, Armes LG, Butler ET 3rd, Vannice JL, Collins F., Science 246(4933), 1989
PMID: 2587985

Export

0 Marked Publications

Open Data PUB

Web of Science

View record in Web of Science®

Sources

PMID: 12106247
PubMed | Europe PMC

Search this title in

Google Scholar