THE IMPORTANCE OF THE RIGIDITY OF THE PEPTIDE BACKBONE FOR THE INHIBITORY PROPERTIES OF BPTI DEMONSTRATED BY SEMISYNTHETIC STRUCTURAL VARIANTS

GROEGER C, Wenzel H, Tschesche H (1993)
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH 32(6): 898-900.

Journal Article | Published | English

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Abstract
''Backbone mutations''-otherwise possible only in model peptides or small peptide hormones by total synthesis-drastically change the biological properties of the trypsin-kallikrein inhibitor (BPTI) and can be selectively introduced into the contact region of the inhibitor by a simple semisynthesis. The derivatives produced in this way show impressively the difference between a substrate-analogous trypsin inhibitor and a trypsin substrate.
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GROEGER C, Wenzel H, Tschesche H. THE IMPORTANCE OF THE RIGIDITY OF THE PEPTIDE BACKBONE FOR THE INHIBITORY PROPERTIES OF BPTI DEMONSTRATED BY SEMISYNTHETIC STRUCTURAL VARIANTS. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH. 1993;32(6):898-900.
GROEGER, C., Wenzel, H., & Tschesche, H. (1993). THE IMPORTANCE OF THE RIGIDITY OF THE PEPTIDE BACKBONE FOR THE INHIBITORY PROPERTIES OF BPTI DEMONSTRATED BY SEMISYNTHETIC STRUCTURAL VARIANTS. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 32(6), 898-900.
GROEGER, C., Wenzel, H., and Tschesche, H. (1993). THE IMPORTANCE OF THE RIGIDITY OF THE PEPTIDE BACKBONE FOR THE INHIBITORY PROPERTIES OF BPTI DEMONSTRATED BY SEMISYNTHETIC STRUCTURAL VARIANTS. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH 32, 898-900.
GROEGER, C., Wenzel, H., & Tschesche, H., 1993. THE IMPORTANCE OF THE RIGIDITY OF THE PEPTIDE BACKBONE FOR THE INHIBITORY PROPERTIES OF BPTI DEMONSTRATED BY SEMISYNTHETIC STRUCTURAL VARIANTS. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 32(6), p 898-900.
C. GROEGER, H. Wenzel, and H. Tschesche, “THE IMPORTANCE OF THE RIGIDITY OF THE PEPTIDE BACKBONE FOR THE INHIBITORY PROPERTIES OF BPTI DEMONSTRATED BY SEMISYNTHETIC STRUCTURAL VARIANTS”, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, vol. 32, 1993, pp. 898-900.
GROEGER, C., Wenzel, H., Tschesche, H.: THE IMPORTANCE OF THE RIGIDITY OF THE PEPTIDE BACKBONE FOR THE INHIBITORY PROPERTIES OF BPTI DEMONSTRATED BY SEMISYNTHETIC STRUCTURAL VARIANTS. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH. 32, 898-900 (1993).
GROEGER, C, Wenzel, Herbert, and Tschesche, Harald. “THE IMPORTANCE OF THE RIGIDITY OF THE PEPTIDE BACKBONE FOR THE INHIBITORY PROPERTIES OF BPTI DEMONSTRATED BY SEMISYNTHETIC STRUCTURAL VARIANTS”. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH 32.6 (1993): 898-900.
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