REDUCTION OF MATRIX METALLOPROTEINASE 8-NEUTROPHIL COLLAGENASE LEVELS DURING LONG-TERM DOXYCYCLINE TREATMENT OF REACTIVE ARTHRITIS

LAUHIO A, KONTTINEN YT, Tschesche H, NORDSTROM D, SALO T, LAHDEVIRTA J, GOLUB LM, SORSA T (1994)
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 38(2): 400-402.

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Zeitschriftenaufsatz | Veröffentlicht | Englisch
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Abstract / Bemerkung
The aim of this work was to determine whether human polymorphonuclear neutrophilic interstitial collagenase (matrix metalloproteinase 8 [MMP-8]) levels are reduced during long-term doxycycline treatment in humans with reactive arthritis. Serum MMP-8 levels were reduced (mean +/- standard error of the mean, 678.9 +/- 185.6 versus 491.2 +/- 144.8 ng of MMP-8 per ml), but not statistically significantly. However, the reduction of salivary MMP-8 levels was statistically significant (3,729 +/- 1,905.3 versus 1,866 +/- 780.0 ng of MMP-8 per ml, P < 0.05). This study demonstrated that a 2-month regimen of doxycycline can reduce MMP-8 levels in serum and especially in body fluids (i.e., saliva) containing inflammatory exudates and thus may contribute to reduced tissue destruction.
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Zeitschriftentitel
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Band
38
Zeitschriftennummer
2
Seite
400-402
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LAUHIO A, KONTTINEN YT, Tschesche H, et al. REDUCTION OF MATRIX METALLOPROTEINASE 8-NEUTROPHIL COLLAGENASE LEVELS DURING LONG-TERM DOXYCYCLINE TREATMENT OF REACTIVE ARTHRITIS. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 1994;38(2):400-402.
LAUHIO, A., KONTTINEN, Y. T., Tschesche, H., NORDSTROM, D., SALO, T., LAHDEVIRTA, J., GOLUB, L. M., et al. (1994). REDUCTION OF MATRIX METALLOPROTEINASE 8-NEUTROPHIL COLLAGENASE LEVELS DURING LONG-TERM DOXYCYCLINE TREATMENT OF REACTIVE ARTHRITIS. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 38(2), 400-402. doi:10.1128/AAC.38.2.400
LAUHIO, A., KONTTINEN, Y. T., Tschesche, H., NORDSTROM, D., SALO, T., LAHDEVIRTA, J., GOLUB, L. M., and SORSA, T. (1994). REDUCTION OF MATRIX METALLOPROTEINASE 8-NEUTROPHIL COLLAGENASE LEVELS DURING LONG-TERM DOXYCYCLINE TREATMENT OF REACTIVE ARTHRITIS. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 38, 400-402.
LAUHIO, A., et al., 1994. REDUCTION OF MATRIX METALLOPROTEINASE 8-NEUTROPHIL COLLAGENASE LEVELS DURING LONG-TERM DOXYCYCLINE TREATMENT OF REACTIVE ARTHRITIS. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 38(2), p 400-402.
A. LAUHIO, et al., “REDUCTION OF MATRIX METALLOPROTEINASE 8-NEUTROPHIL COLLAGENASE LEVELS DURING LONG-TERM DOXYCYCLINE TREATMENT OF REACTIVE ARTHRITIS”, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 38, 1994, pp. 400-402.
LAUHIO, A., KONTTINEN, Y.T., Tschesche, H., NORDSTROM, D., SALO, T., LAHDEVIRTA, J., GOLUB, L.M., SORSA, T.: REDUCTION OF MATRIX METALLOPROTEINASE 8-NEUTROPHIL COLLAGENASE LEVELS DURING LONG-TERM DOXYCYCLINE TREATMENT OF REACTIVE ARTHRITIS. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 38, 400-402 (1994).
LAUHIO, A, KONTTINEN, YT, Tschesche, Harald, NORDSTROM, D, SALO, T, LAHDEVIRTA, J, GOLUB, LM, and SORSA, T. “REDUCTION OF MATRIX METALLOPROTEINASE 8-NEUTROPHIL COLLAGENASE LEVELS DURING LONG-TERM DOXYCYCLINE TREATMENT OF REACTIVE ARTHRITIS”. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 38.2 (1994): 400-402.

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