REDUCTION OF MATRIX METALLOPROTEINASE 8-NEUTROPHIL COLLAGENASE LEVELS DURING LONG-TERM DOXYCYCLINE TREATMENT OF REACTIVE ARTHRITIS

LAUHIO A, KONTTINEN YT, Tschesche H, NORDSTROM D, SALO T, LAHDEVIRTA J, GOLUB LM, SORSA T (1994)
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 38(2): 400-402.

Journal Article | Published | English

No fulltext has been uploaded

Author
; ; ; ; ; ; ;
Abstract
The aim of this work was to determine whether human polymorphonuclear neutrophilic interstitial collagenase (matrix metalloproteinase 8 [MMP-8]) levels are reduced during long-term doxycycline treatment in humans with reactive arthritis. Serum MMP-8 levels were reduced (mean +/- standard error of the mean, 678.9 +/- 185.6 versus 491.2 +/- 144.8 ng of MMP-8 per ml), but not statistically significantly. However, the reduction of salivary MMP-8 levels was statistically significant (3,729 +/- 1,905.3 versus 1,866 +/- 780.0 ng of MMP-8 per ml, P < 0.05). This study demonstrated that a 2-month regimen of doxycycline can reduce MMP-8 levels in serum and especially in body fluids (i.e., saliva) containing inflammatory exudates and thus may contribute to reduced tissue destruction.
Publishing Year
ISSN
eISSN
PUB-ID

Cite this

LAUHIO A, KONTTINEN YT, Tschesche H, et al. REDUCTION OF MATRIX METALLOPROTEINASE 8-NEUTROPHIL COLLAGENASE LEVELS DURING LONG-TERM DOXYCYCLINE TREATMENT OF REACTIVE ARTHRITIS. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 1994;38(2):400-402.
LAUHIO, A., KONTTINEN, Y. T., Tschesche, H., NORDSTROM, D., SALO, T., LAHDEVIRTA, J., GOLUB, L. M., et al. (1994). REDUCTION OF MATRIX METALLOPROTEINASE 8-NEUTROPHIL COLLAGENASE LEVELS DURING LONG-TERM DOXYCYCLINE TREATMENT OF REACTIVE ARTHRITIS. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 38(2), 400-402.
LAUHIO, A., KONTTINEN, Y. T., Tschesche, H., NORDSTROM, D., SALO, T., LAHDEVIRTA, J., GOLUB, L. M., and SORSA, T. (1994). REDUCTION OF MATRIX METALLOPROTEINASE 8-NEUTROPHIL COLLAGENASE LEVELS DURING LONG-TERM DOXYCYCLINE TREATMENT OF REACTIVE ARTHRITIS. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 38, 400-402.
LAUHIO, A., et al., 1994. REDUCTION OF MATRIX METALLOPROTEINASE 8-NEUTROPHIL COLLAGENASE LEVELS DURING LONG-TERM DOXYCYCLINE TREATMENT OF REACTIVE ARTHRITIS. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 38(2), p 400-402.
A. LAUHIO, et al., “REDUCTION OF MATRIX METALLOPROTEINASE 8-NEUTROPHIL COLLAGENASE LEVELS DURING LONG-TERM DOXYCYCLINE TREATMENT OF REACTIVE ARTHRITIS”, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 38, 1994, pp. 400-402.
LAUHIO, A., KONTTINEN, Y.T., Tschesche, H., NORDSTROM, D., SALO, T., LAHDEVIRTA, J., GOLUB, L.M., SORSA, T.: REDUCTION OF MATRIX METALLOPROTEINASE 8-NEUTROPHIL COLLAGENASE LEVELS DURING LONG-TERM DOXYCYCLINE TREATMENT OF REACTIVE ARTHRITIS. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 38, 400-402 (1994).
LAUHIO, A, KONTTINEN, YT, Tschesche, Harald, NORDSTROM, D, SALO, T, LAHDEVIRTA, J, GOLUB, LM, and SORSA, T. “REDUCTION OF MATRIX METALLOPROTEINASE 8-NEUTROPHIL COLLAGENASE LEVELS DURING LONG-TERM DOXYCYCLINE TREATMENT OF REACTIVE ARTHRITIS”. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 38.2 (1994): 400-402.
This data publication is cited in the following publications:
This publication cites the following data publications:

14 Citations in Europe PMC

Data provided by Europe PubMed Central.

Performance of multiplex cytokine assays in serum and saliva among community-dwelling postmenopausal women.
Browne RW, Kantarci A, LaMonte MJ, Andrews CA, Hovey KM, Falkner KL, Cekici A, Stephens D, Genco RJ, Scannapieco FA, Van Dyke TE, Wactawski-Wende J., PLoS ONE 8(4), 2013
PMID: 23577067
Matrix metalloproteinase-8/collagenase-2 in childhood otitis media with effusion.
Lauhio A, Rezes S, Tervahartiala T, Sziklai I, Pitkaranta A, Sorsa T., Ann. Med. 44(1), 2012
PMID: 21047154
Serum MMP-8, -9 and TIMP-1 in sepsis: high serum levels of MMP-8 and TIMP-1 are associated with fatal outcome in a multicentre, prospective cohort study. Hypothetical impact of tetracyclines.
Lauhio A, Hastbacka J, Pettila V, Tervahartiala T, Karlsson S, Varpula T, Varpula M, Ruokonen E, Sorsa T, Kolho E., Pharmacol. Res. 64(6), 2011
PMID: 21742038
Assessment of systemic matrix metalloproteinase and their regulator response in children with Helicobacter pylori gastritis.
Rautelin H, Tervahartiala T, Lauhio A, Sorsa T, Kolho KL., Scand. J. Clin. Lab. Invest. 70(7), 2010
PMID: 20854182
Slow release antibiotics for treatment of septic arthritis in large animals.
Haerdi-Landerer MC, Habermacher J, Wenger B, Suter MM, Steiner A., Vet. J. 184(1), 2010
PMID: 19345594
Modification of collagen formation using supplemented mesh materials.
Junge K, Rosch R, Anurov M, Titkova S, Ottinger A, Klinge U, Schumpelick V., Hernia 10(6), 2006
PMID: 17028794
Proteases and the diabetic foot syndrome: mechanisms and therapeutic implications.
Lobmann R, Schultz G, Lehnert H., Diabetes Care 28(2), 2005
PMID: 15677818
MMP inhibition and downregulation by bisphosphonates.
Teronen O, Heikkila P, Konttinen YT, Laitinen M, Salo T, Hanemaaijer R, Teronen A, Maisi P, Sorsa T., Ann. N. Y. Acad. Sci. 878(), 1999
PMID: 10415748
Wound fluids from human pressure ulcers contain elevated matrix metalloproteinase levels and activity compared to surgical wound fluids.
Yager DR, Zhang LY, Liang HX, Diegelmann RF, Cohen IK., J. Invest. Dermatol. 107(5), 1996
PMID: 8875960
The gelatinase inhibitory activity of tetracyclines and chemically modified tetracycline analogues as measured by a novel microtiter assay for inhibitors.
Paemen L, Martens E, Norga K, Masure S, Roets E, Hoogmartens J, Opdenakker G., Biochem. Pharmacol. 52(1), 1996
PMID: 8678893
Protease inhibitors: role and potential therapeutic use in human cancer.
DeClerck YA, Imren S., Eur. J. Cancer 30A(14), 1994
PMID: 7857719
Effects of tetracyclines on neutrophil, gingival, and salivary collagenases. A functional and western-blot assessment with special reference to their cellular sources in periodontal diseases.
Sorsa T, Ding Y, Salo T, Lauhio A, Teronen O, Ingman T, Ohtani H, Andoh N, Takeha S, Konttinen YT., Ann. N. Y. Acad. Sci. 732(), 1994
PMID: 7978785

17 References

Data provided by Europe PubMed Central.

Enzyme linked immunosorbent assays (ELISA) for the quantitative determination of human leukocyte collagenase and gelatinase.
Bergmann U, Michaelis J, Oberhoff R, Knauper V, Beckmann R, Tschesche H., J. Clin. Chem. Clin. Biochem. 27(6), 1989
PMID: 2547014
Minocycline treatment for rheumatoid arthritis: an open dose finding study.
Breedveld FC, Dijkmans BA, Mattie H., J. Rheumatol. 17(1), 1990
PMID: 2313671
Low-dose doxycycline therapy: effect on gingival and crevicular fluid collagenase activity in humans.
Golub LM, Ciancio S, Ramamamurthy NS, Leung M, McNamara TF., J. Periodont. Res. 25(6), 1990
PMID: 2177499
Host modulation with tetracyclines and their chemically modified analogues.
Golub LM, Suomalainen K, Sorsa T., Curr Opin Dent 2(), 1992
PMID: 1325849
Salivary collagenase, elastase- and trypsin-like proteases as biochemical markers of periodontal tissue destruction in adult and localized juvenile periodontitis.
Ingman T, Sorsa T, Konttinen YT, Liede K, Saari H, Lindy O, Suomalainen K., Oral Microbiol. Immunol. 8(5), 1993
PMID: 8265204
Tetracycline inhibition and the cellular source of collagenase in gingival crevicular fluid in different periodontal diseases. A review article.
Ingman T, Sorsa T, Suomalainen K, Halinen S, Lindy O, Lauhio A, Saari H, Konttinen YT, Golub LM., J. Periodontol. 64(2), 1993
PMID: 8433257
The anticollagenolytic potential of lymecycline in the long-term treatment of reactive arthritis.
Lauhio A, Sorsa T, Lindy O, Suomalainen K, Saari H, Golub LM, Konttinen YT., Arthritis Rheum. 35(2), 1992
PMID: 1310409
The regulatory role of doxycycline/tetracycline in collagenolytic activity and tissue destruction in joint diseases: comment on the article by Yu et al.
Lauhio A, Sorsa T, Lindy O, Suomalainen K, Saari H, Golub LM, Konttinen YT., Arthritis Rheum. 36(9), 1993
PMID: 8216431
Metalloproteinases and tissue damage.
Murphy G, Docherty AJ, Hembry RM, Reynolds JJ., Br. J. Rheumatol. 30 Suppl 1(), 1991
PMID: 1991237
Reactive oxygen species activate and tetracyclines inhibit rat osteoblast collagenase.
Ramamurthy NS, Vernillo AT, Greenwald RA, Lee HM, Sorsa T, Golub LM, Rifkin BR., J. Bone Miner. Res. 8(10), 1993
PMID: 8256662
Doxycycline in the protection of serum alpha-1-antitrypsin from human neutrophil collagenase and gelatinase.
Sorsa T, Lindy O, Konttinen YT, Suomalainen K, Ingman T, Saari H, Halinen S, Lee HM, Golub LM, Hall J., Antimicrob. Agents Chemother. 37(3), 1993
PMID: 8384819
Specificity of the anticollagenase action of tetracyclines: relevance to their anti-inflammatory potential.
Suomalainen K, Sorsa T, Golub LM, Ramamurthy N, Lee HM, Uitto VJ, Saari H, Konttinen YT., Antimicrob. Agents Chemother. 36(1), 1992
PMID: 1317148
Angiogenesis inhibition by minocycline.
Tamargo RJ, Bok RA, Brem H., Cancer Res. 51(2), 1991
PMID: 1702361
Tissue destruction by neutrophils.
Weiss SJ., N. Engl. J. Med. 320(6), 1989
PMID: 2536474
Reduction of the severity of canine osteoarthritis by prophylactic treatment with oral doxycycline.
Yu LP Jr, Smith GN Jr, Brandt KD, Myers SL, O'Connor BL, Brandt DA., Arthritis Rheum. 35(10), 1992
PMID: 1329773

Export

0 Marked Publications

Open Data PUB

Web of Science

View record in Web of Science®

Sources

PMID: 8192476
PubMed | Europe PMC

Search this title in

Google Scholar