THE METABOLITES OF THE HERBICIDE L-PHOSPHINOTHRICIN (GLUFOSINATE) - IDENTIFICATION, STABILITY, AND MOBILITY IN TRANSGENIC, HERBICIDE-RESISTANT, AND UNTRANSFORMED PLANTS

DROGELASER W, SIEMELING U, Pühler A, BROER I (1994)
PLANT PHYSIOLOGY 105(1): 159-166.

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The metabolism of the herbicide L-phosphinothricin (L-Pt) was analyzed in tobacco (Nicotiana tabacum), alfalfa (Medicago sativa), and carrot (Daucus carota). In transgenic, Pt-resistant plants expressing the Pt-N-acetyltransferase gene (pat), L-Pt was acetylated, resulting in two forms of N-acetyl-Pt (ac-Pt). In transgenic plants expressing only low pat-encoded acetylating activity as well as in genetically unmodified plants, three metabolic compounds 4-methylphosphinico-2-oxo-butanoic acid, 3-methylphosphinico-propanoic acid (MPP), and 4-methylphosphinico-2-hydroxy-butanoic acid (MHB) were identified. Hence, the transgene-encoded acetylation of L-Pt competes with a plant-specific degradation. The compounds MPP, MHB, and ac-Pt were found to be the final, stable products of the plant's metabolic pathways. The mobility of these stable compounds in the plant was investigated: L-Pt as well as the derived metabolites were found to be preferentially transported to the upper regions of the plant.
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DROGELASER W, SIEMELING U, Pühler A, BROER I. THE METABOLITES OF THE HERBICIDE L-PHOSPHINOTHRICIN (GLUFOSINATE) - IDENTIFICATION, STABILITY, AND MOBILITY IN TRANSGENIC, HERBICIDE-RESISTANT, AND UNTRANSFORMED PLANTS. PLANT PHYSIOLOGY. 1994;105(1):159-166.
DROGELASER, W., SIEMELING, U., Pühler, A., & BROER, I. (1994). THE METABOLITES OF THE HERBICIDE L-PHOSPHINOTHRICIN (GLUFOSINATE) - IDENTIFICATION, STABILITY, AND MOBILITY IN TRANSGENIC, HERBICIDE-RESISTANT, AND UNTRANSFORMED PLANTS. PLANT PHYSIOLOGY, 105(1), 159-166.
DROGELASER, W., SIEMELING, U., Pühler, A., and BROER, I. (1994). THE METABOLITES OF THE HERBICIDE L-PHOSPHINOTHRICIN (GLUFOSINATE) - IDENTIFICATION, STABILITY, AND MOBILITY IN TRANSGENIC, HERBICIDE-RESISTANT, AND UNTRANSFORMED PLANTS. PLANT PHYSIOLOGY 105, 159-166.
DROGELASER, W., et al., 1994. THE METABOLITES OF THE HERBICIDE L-PHOSPHINOTHRICIN (GLUFOSINATE) - IDENTIFICATION, STABILITY, AND MOBILITY IN TRANSGENIC, HERBICIDE-RESISTANT, AND UNTRANSFORMED PLANTS. PLANT PHYSIOLOGY, 105(1), p 159-166.
W. DROGELASER, et al., “THE METABOLITES OF THE HERBICIDE L-PHOSPHINOTHRICIN (GLUFOSINATE) - IDENTIFICATION, STABILITY, AND MOBILITY IN TRANSGENIC, HERBICIDE-RESISTANT, AND UNTRANSFORMED PLANTS”, PLANT PHYSIOLOGY, vol. 105, 1994, pp. 159-166.
DROGELASER, W., SIEMELING, U., Pühler, A., BROER, I.: THE METABOLITES OF THE HERBICIDE L-PHOSPHINOTHRICIN (GLUFOSINATE) - IDENTIFICATION, STABILITY, AND MOBILITY IN TRANSGENIC, HERBICIDE-RESISTANT, AND UNTRANSFORMED PLANTS. PLANT PHYSIOLOGY. 105, 159-166 (1994).
DROGELASER, W, SIEMELING, U, Pühler, Alfred, and BROER, I. “THE METABOLITES OF THE HERBICIDE L-PHOSPHINOTHRICIN (GLUFOSINATE) - IDENTIFICATION, STABILITY, AND MOBILITY IN TRANSGENIC, HERBICIDE-RESISTANT, AND UNTRANSFORMED PLANTS”. PLANT PHYSIOLOGY 105.1 (1994): 159-166.
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