IN-VIVO INHIBITION OF HUMAN NEUTROPHIL COLLAGENASE (MMP-8) ACTIVITY DURING LONG-TERM COMBINATION THERAPY OF DOXYCYCLINE AND NONSTEROIDAL ANTIINFLAMMATORY DRUGS (NSAID) IN ACUTE REACTIVE ARTHRITIS

LAUHIO A, SALO T, DING Y, KONTTINEN YT, NORDSTROM D, Tschesche H, LAHDEVIRTA J, GOLUB LM, SORSA T (1994)
CLINICAL AND EXPERIMENTAL IMMUNOLOGY 98(1): 21-28.

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Zeitschriftenaufsatz | Veröffentlicht | Englisch
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Abstract / Bemerkung
We studied the in vivo effect of long-term doxycycline treatment combined with NSAID on human interstitial collagenases, other matrix metalloproteinases, serine proteinases, tissue inhibitor of matrix metalloproteinase-l (TIMP-1) and lactoferrin from saliva and serum during the course of acute reactive arthritis (ReA). Collagenase activity and serine proteases (elastase-like, cathepsin G-like and trypsin-like activities) of saliva (n = 10) and gelatinase, lactoferrin and TIMP-1 of saliva (E = 10) and serum (n = 10) samples before and after 2 months doxycycline treatment, combined with NSAID, were studied by quantitative SDS-PAGE assay, ELISA assay and by spectrophotometric assay. The cellular source and molecular forms of salivary collagenase were characterized by immunoblotting using specific antisera. We found that activities of total and endogenously active interstitial collagenase reduced significantly. The salivary collagenase was found to originate from neutrophils. No fragmentation of either pro 75-kD and active 65-kD MMP-8 was detected after 2 months doxycycline treatment. However, during 2 months doxycycline and NSAID treatment no reduction of salivary and serum gelatinase, lactoferrin and TIMP-1-levels and salivary serine protease activities were detected. The in vivo inhibition of collagenase (MMP-8) activity during long-term doxycycline therapy in human saliva containing inflammatory exudate of ReA patients may contribute to the reduced tissue destruction observed in recent clinical and animal model studies in arthritides during long-term doxycycline/tetracycline treatment.
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CLINICAL AND EXPERIMENTAL IMMUNOLOGY
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98
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1
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21-28
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LAUHIO A, SALO T, DING Y, et al. IN-VIVO INHIBITION OF HUMAN NEUTROPHIL COLLAGENASE (MMP-8) ACTIVITY DURING LONG-TERM COMBINATION THERAPY OF DOXYCYCLINE AND NONSTEROIDAL ANTIINFLAMMATORY DRUGS (NSAID) IN ACUTE REACTIVE ARTHRITIS. CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 1994;98(1):21-28.
LAUHIO, A., SALO, T., DING, Y., KONTTINEN, Y. T., NORDSTROM, D., Tschesche, H., LAHDEVIRTA, J., et al. (1994). IN-VIVO INHIBITION OF HUMAN NEUTROPHIL COLLAGENASE (MMP-8) ACTIVITY DURING LONG-TERM COMBINATION THERAPY OF DOXYCYCLINE AND NONSTEROIDAL ANTIINFLAMMATORY DRUGS (NSAID) IN ACUTE REACTIVE ARTHRITIS. CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 98(1), 21-28.
LAUHIO, A., SALO, T., DING, Y., KONTTINEN, Y. T., NORDSTROM, D., Tschesche, H., LAHDEVIRTA, J., GOLUB, L. M., and SORSA, T. (1994). IN-VIVO INHIBITION OF HUMAN NEUTROPHIL COLLAGENASE (MMP-8) ACTIVITY DURING LONG-TERM COMBINATION THERAPY OF DOXYCYCLINE AND NONSTEROIDAL ANTIINFLAMMATORY DRUGS (NSAID) IN ACUTE REACTIVE ARTHRITIS. CLINICAL AND EXPERIMENTAL IMMUNOLOGY 98, 21-28.
LAUHIO, A., et al., 1994. IN-VIVO INHIBITION OF HUMAN NEUTROPHIL COLLAGENASE (MMP-8) ACTIVITY DURING LONG-TERM COMBINATION THERAPY OF DOXYCYCLINE AND NONSTEROIDAL ANTIINFLAMMATORY DRUGS (NSAID) IN ACUTE REACTIVE ARTHRITIS. CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 98(1), p 21-28.
A. LAUHIO, et al., “IN-VIVO INHIBITION OF HUMAN NEUTROPHIL COLLAGENASE (MMP-8) ACTIVITY DURING LONG-TERM COMBINATION THERAPY OF DOXYCYCLINE AND NONSTEROIDAL ANTIINFLAMMATORY DRUGS (NSAID) IN ACUTE REACTIVE ARTHRITIS”, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, vol. 98, 1994, pp. 21-28.
LAUHIO, A., SALO, T., DING, Y., KONTTINEN, Y.T., NORDSTROM, D., Tschesche, H., LAHDEVIRTA, J., GOLUB, L.M., SORSA, T.: IN-VIVO INHIBITION OF HUMAN NEUTROPHIL COLLAGENASE (MMP-8) ACTIVITY DURING LONG-TERM COMBINATION THERAPY OF DOXYCYCLINE AND NONSTEROIDAL ANTIINFLAMMATORY DRUGS (NSAID) IN ACUTE REACTIVE ARTHRITIS. CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 98, 21-28 (1994).
LAUHIO, A, SALO, T, DING, Y, KONTTINEN, YT, NORDSTROM, D, Tschesche, Harald, LAHDEVIRTA, J, GOLUB, LM, and SORSA, T. “IN-VIVO INHIBITION OF HUMAN NEUTROPHIL COLLAGENASE (MMP-8) ACTIVITY DURING LONG-TERM COMBINATION THERAPY OF DOXYCYCLINE AND NONSTEROIDAL ANTIINFLAMMATORY DRUGS (NSAID) IN ACUTE REACTIVE ARTHRITIS”. CLINICAL AND EXPERIMENTAL IMMUNOLOGY 98.1 (1994): 21-28.

52 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Proteolytic Mediators in Gestational Diabetes Mellitus and Gingivitis.
Akcalı A, Gümüş P, Özçaka Ö, Öztürk-Ceyhan B, Tervahartiala T, Husu H, Heikkinen AM, Sorsa T, Buduneli N., J Periodontol 88(3), 2017
PMID: 27762733
Subclinical inflammation associated with prolonged TIMP-1 upregulation and arterial stiffness after gestational diabetes mellitus: a hospital-based cohort study.
Vilmi-Kerälä T, Lauhio A, Tervahartiala T, Palomäki O, Uotila J, Sorsa T, Palomäki A., Cardiovasc Diabetol 16(1), 2017
PMID: 28407807
Association study of MMP8 gene in osteoarthritis.
Näkki A, Rodriguez-Fontenla C, Gonzalez A, Harilainen A, Leino-Arjas P, Heliövaara M, Eriksson JG, Tallroth K, Videman T, Kaprio J, Saarela J, Kujala UM., Connect Tissue Res 57(1), 2016
PMID: 26577236
Association of MMP-8 with obesity, smoking and insulin resistance.
Lauhio A, Färkkilä E, Pietiläinen KH, Åström P, Winkelmann A, Tervahartiala T, Pirilä E, Rissanen A, Kaprio J, Sorsa TA, Salo T., Eur J Clin Invest 46(9), 2016
PMID: 27296149
Do salivary and serum collagenases have a role in an association between obstructive sleep apnea syndrome and periodontal disease? A preliminary case-control study.
Nizam N, Basoglu OK, Tasbakan MS, Holthöfer A, Tervahartiala T, Sorsa T, Buduneli N., Arch Oral Biol 60(1), 2015
PMID: 25455127
Elevated matrix metalloproteinase-8 in saliva and serum in polycystic ovary syndrome and association with gingival inflammation.
Akcalı A, Bostanci N, Özçaka Ö, Öztürk-Ceyhan B, Gümüş P, Tervahartiala T, Husu H, Buduneli N, Sorsa T, Belibasakis GN., Innate Immun 21(6), 2015
PMID: 25712810
Serum and salivary matrix metalloproteinases, neutrophil elastase, myeloperoxidase in patients with chronic or aggressive periodontitis.
Nizam N, Gümüş P, Pitkänen J, Tervahartiala T, Sorsa T, Buduneli N., Inflammation 37(5), 2014
PMID: 24799321
Synthesis and antibacterial activity of doxycycline neoglycosides.
Zhang J, Ponomareva LV, Marchillo K, Zhou M, Andes DR, Thorson JS., J Nat Prod 76(9), 2013
PMID: 23987662
Matrix metalloproteinase-8/collagenase-2 in childhood otitis media with effusion.
Lauhio A, Rezes S, Tervahartiala T, Sziklai I, Pitkäranta A, Sorsa T., Ann Med 44(1), 2012
PMID: 21047154
Basement membrane collagen type IV expression by human mesenchymal stem cells during adipogenic differentiation.
Sillat T, Saat R, Pöllänen R, Hukkanen M, Takagi M, Konttinen YT., J Cell Mol Med 16(7), 2012
PMID: 21883898
Acute myocardial infarction is reflected in salivary matrix metalloproteinase-8 activation level.
Buduneli E, Mäntylä P, Emingil G, Tervahartiala T, Pussinen P, Barış N, Akıllı A, Atilla G, Sorsa T., J Periodontol 82(5), 2011
PMID: 21091346
Serum MMP-8, -9 and TIMP-1 in sepsis: high serum levels of MMP-8 and TIMP-1 are associated with fatal outcome in a multicentre, prospective cohort study. Hypothetical impact of tetracyclines.
Lauhio A, Hästbacka J, Pettilä V, Tervahartiala T, Karlsson S, Varpula T, Varpula M, Ruokonen E, Sorsa T, Kolho E., Pharmacol Res 64(6), 2011
PMID: 21742038
Crevicular fluid matrix metalloproteinase-8, -13, and TIMP-1 levels in type 2 diabetics.
Kardeşler L, Biyikoğlu B, Cetinkalp S, Pitkala M, Sorsa T, Buduneli N., Oral Dis 16(5), 2010
PMID: 20233316
Gingival crevicular fluid MMP-8 and -13 and TIMP-1 levels in patients with rheumatoid arthritis and inflammatory periodontal disease.
Biyikoğlu B, Buduneli N, Kardeşler L, Aksu K, Pitkala M, Sorsa T., J Periodontol 80(8), 2009
PMID: 19656031
Urinary matrix metalloproteinase -8, -9, -14 and their regulators (TRY-1, TRY-2, TATI) in patients with diabetic nephropathy.
Lauhio A, Sorsa T, Srinivas R, Stenman M, Tervahartiala T, Stenman UH, Grönhagen-Riska C, Honkanen E., Ann Med 40(4), 2008
PMID: 18428024
Elevated expression and activation of matrix metalloproteinase 8 in tear fluid in atopic blepharoconjunctivitis.
Määttä M, Kari O, Tervahartiala T, Wahlgren J, Peltonen S, Kari M, Rytilä P, Saari M, Sorsa T., Cornea 27(3), 2008
PMID: 18362656
Collagenase 2/matrix metalloproteinase 8 in critically ill patients with secondary peritonitis.
Hästbacka J, Hynninen M, Kolho E, Pettilä V, Tervahartiala T, Sorsa T, Lauhio A., Shock 27(2), 2007
PMID: 17224788
Matrix metalloproteinases: contribution to pathogenesis, diagnosis and treatment of periodontal inflammation.
Sorsa T, Tjäderhane L, Konttinen YT, Lauhio A, Salo T, Lee HM, Golub LM, Brown DL, Mäntylä P., Ann Med 38(5), 2006
PMID: 16938801
Tear fluid levels of MMP-8 are elevated in ocular rosacea--treatment effect of oral doxycycline.
Määttä M, Kari O, Tervahartiala T, Peltonen S, Kari M, Saari M, Sorsa T., Graefes Arch Clin Exp Ophthalmol 244(8), 2006
PMID: 16411105
Levels and activation of matrix metalloproteinases in aqueous humor are elevated in uveitis-related secondary glaucoma.
Määttä M, Tervahartiala T, Vesti E, Airaksinen J, Sorsa T., J Glaucoma 15(3), 2006
PMID: 16778646
Matrix metalloproteinase 10 promotion of collagenolysis via procollagenase activation: implications for cartilage degradation in arthritis.
Barksby HE, Milner JM, Patterson AM, Peake NJ, Hui W, Robson T, Lakey R, Middleton J, Cawston TE, Richards CD, Rowan AD., Arthritis Rheum 54(10), 2006
PMID: 17009259
Matrix metalloproteinase-2 (MMP-2) and MMP-9 in pulmonary pathology.
Chakrabarti S, Patel KD., Exp Lung Res 31(6), 2005
PMID: 16019990
HLA-B27-associated reactive arthritis: pathogenetic and clinical considerations.
Colmegna I, Cuchacovich R, Espinoza LR., Clin Microbiol Rev 17(2), 2004
PMID: 15084505
Expression and regulation of collagenase-2 (MMP-8) in head and neck squamous cell carcinomas.
Moilanen M, Pirilä E, Grénman R, Sorsa T, Salo T., J Pathol 197(1), 2002
PMID: 12081207
Collagenolytic activity in bronchoalveolar lavage fluid in canine pulmonary eosinophilia.
Rajamäki MM, Järvinen AK, Sorsa T, Maisi P., J Vet Intern Med 16(6), 2002
PMID: 12465761
The expression of MMP-8 in human odontoblasts and dental pulp cells is down-regulated by TGF-beta1.
Palosaari H, Wahlgren J, Larmas M, Rönkä H, Sorsa T, Salo T, Tjäderhane L., J Dent Res 79(1), 2000
PMID: 10690664
Uptake of tetracycline by aortic aneurysm wall and its effect on inflammation and proteolysis.
Franklin IJ, Harley SL, Greenhalgh RM, Powell JT., Br J Surg 86(6), 1999
PMID: 10383577
MMP inhibition and downregulation by bisphosphonates.
Teronen O, Heikkilä P, Konttinen YT, Laitinen M, Salo T, Hanemaaijer R, Teronen A, Maisi P, Sorsa T., Ann N Y Acad Sci 878(), 1999
PMID: 10415748
The association between smoking cessation and periodontal status and salivary proteinase levels.
Liede KE, Haukka JK, Hietanen JH, Mattila MH, Rönkä H, Sorsa T., J Periodontol 70(11), 1999
PMID: 10588500
Doxymycine-cyanoacrylate treatment of recurrent aphthous ulcers.
Ylikontiola L, Sorsa T, Häyrinen-Immonen R, Salo T., Oral Surg Oral Med Oral Pathol Oral Radiol Endod 83(3), 1997
PMID: 9084194
Response of Behçet's syndrome to brand-name but not generic tetracycline.
Cohen JB, Bergstresser PR., Clin Exp Dermatol 22(3), 1997
PMID: 9425700
Doxyclycline inhibits collagen synthesis by bovine chondrocytes cultured in alginate.
Beekman B, Verzijl N, de Roos JA, Koopman JL, TeKoppele JM., Biochem Biophys Res Commun 237(1), 1997
PMID: 9266839
Human neutrophil collagenase MMP-8 in peri-implant sulcus fluid and its inhibition by clodronate.
Teronen O, Konttinen YT, Lindqvist C, Salo T, Ingman T, Lauhio A, Ding Y, Santavirta S, Sorsa T., J Dent Res 76(9), 1997
PMID: 9294486
Doxycycline reduces early neurologic impairment after cerebral arterial air embolism in the rabbit.
Reasoner DK, Hindman BJ, Dexter F, Subieta A, Cutkomp J, Smith T., Anesthesiology 87(3), 1997
PMID: 9316962
Matrix metalloproteinases, gelatinase and collagenase, in chronic leg ulcers.
Weckroth M, Vaheri A, Lauharanta J, Sorsa T, Konttinen YT., J Invest Dermatol 106(5), 1996
PMID: 8618050
Wound fluids from human pressure ulcers contain elevated matrix metalloproteinase levels and activity compared to surgical wound fluids.
Yager DR, Zhang LY, Liang HX, Diegelmann RF, Cohen IK., J Invest Dermatol 107(5), 1996
PMID: 8875960
Characterization of interstitial collagenases in jaw cyst wall.
Teronen O, Salo T, Laitinen J, Törnwall J, Ylipaavalniemi P, Konttinen YT, Hietanen J, Sorsa T., Eur J Oral Sci 103(3), 1995
PMID: 7634129
Tetracyclines in treatment of rheumatoid arthritis.
Lauhio A, Salo T, Tjäderhane L, Lähdevirta J, Golub LM, Sorsa T., Lancet 346(8975), 1995
PMID: 7651040

39 References

Daten bereitgestellt von Europe PubMed Central.

Reiter's syndrome and reactive arthritis in perspective.
Keat A., N. Engl. J. Med. 309(26), 1983
PMID: 6358890
Chlamydia trachomatis and reactive arthritis: the missing link
Keat, Lancet i(), 1987
Reactive arthritis associated with Shigella sonnei infection.
Lauhio A, Lahdevirta J, Janes R, Kontiainen S, Repo H., Arthritis Rheum. 31(9), 1988
PMID: 3048277
Do bacterial antigens cause reactive arthritis?
Granfors K., Rheum. Dis. Clin. North Am. 18(1), 1992
PMID: 1561408
Effect of antimicrobial treatment on chronic reactive arthritis.
Toivanen A, Yli-Kerttula T, Luukkainen R, Merilahti-Palo R, Granfors K, Seppala J., Clin. Exp. Rheumatol. 11(3), 1993
PMID: 8353985
Chlamydia and Reiter's syndrome (reactive arthritis).
Rahman MU, Hudson AP, Schumacher HR Jr., Rheum. Dis. Clin. North Am. 18(1), 1992
PMID: 1561410
Yersinia antigens in synovial-fluid cells from patients with reactive arthritis.
Granfors K, Jalkanen S, von Essen R, Lahesmaa-Rantala R, Isomaki O, Pekkola-Heino K, Merilahti-Palo R, Saario R, Isomaki H, Toivanen A., N. Engl. J. Med. 320(4), 1989
PMID: 2643047
Salmonella lipopolysaccharide in synovial cells from patients with reactive arthritis.
Granfors K, Jalkanen S, Lindberg AA, Maki-Ikola O, von Essen R, Lahesmaa-Rantala R, Isomaki H, Saario R, Arnold WJ, Toivanen A., Lancet 335(8691), 1990
PMID: 1690327
Antibiotic treatment of venereal disease and Reiter's syndrome in a Greenland population
Bardin, Arthritis Rheum 5(), 1992
Chlamydia-induced arthritis: antibiotic treatment and follow-up study
Zeidler, Abstr Arthritis Rheum 9(Suppl.), 1991
Host modulation with tetracyclines and their chemically modified analogues.
Golub LM, Suomalainen K, Sorsa T., Curr Opin Dent 2(), 1992
PMID: 1325849
The anticollagenolytic potential of lymecycline in the long-term treatment of reactive arthritis.
Lauhio A, Sorsa T, Lindy O, Suomalainen K, Saari H, Golub LM, Konttinen YT., Arthritis Rheum. 35(2), 1992
PMID: 1310409
Reduction of the severity of canine osteoarthritis by prophylactic treatment with oral doxycycline.
Yu LP Jr, Smith GN Jr, Brandt KD, Myers SL, O'Connor BL, Brandt DA., Arthritis Rheum. 35(10), 1992
PMID: 1329773
Minocycline treatment for rheumatoid arthritis: an open dose finding study.
Breedveld FC, Dijkmans BA, Mattie H., J. Rheumatol. 17(1), 1990
PMID: 2313671
Low-dose doxycycline therapy: effect on gingival and crevicular fluid collagenase activity in humans
Golub, J Periodontal Res 25(), 1991
Salivary collagenase. Origin, characteristics and relationship to periodontal health.
Uitto VJ, Suomalainen K, Sorsa T., J. Periodont. Res. 25(3), 1990
PMID: 2163444
Specificity of the anticollagenase action of tetracyclines: relevance to their anti-inflammatory potential.
Suomalainen K, Sorsa T, Golub LM, Ramamurthy N, Lee HM, Uitto VJ, Saari H, Konttinen YT., Antimicrob. Agents Chemother. 36(1), 1992
PMID: 1317148
Problems and proposals for recording gingivitis and plaque.
Ainamo J, Bay I., Int Dent J 25(4), 1975
PMID: 1058834
Tetracycline inhibition and the cellular source of collagenase in gingival crevicular fluid in different periodontal diseases. A review article.
Ingman T, Sorsa T, Suomalainen K, Halinen S, Lindy O, Lauhio A, Saari H, Konttinen YT, Golub LM., J. Periodontol. 64(2), 1993
PMID: 8433257
Salivary collagenase, elastase- and trypsin-like proteases as biochemical markers of periodontal tissue destruction in adult and localized juvenile periodontitis.
Ingman T, Sorsa T, Konttinen YT, Liede K, Saari H, Lindy O, Suomalainen K., Oral Microbiol. Immunol. 8(5), 1993
PMID: 8265204
Enzyme linked immunoassay (ELISA) for quantitative determination of human leukocyte collagenase and gelatinase
Bergman, J Clin Chem Biol 27(), 1989
Activation of latent collagenase purified from human leukocytes.
Sorsa TA., Scand. J. Rheumatol. 16(3), 1987
PMID: 3037686
Substrate specificity and activation mechanisms of collagenase from human rheumatoid synovium.
Konttinen YT, Lindy O, Suomalainen K, Ritchlin C, Saari H, Vauhkonen M, Lauhio A, Santavirta S, Sorsa T., Matrix 11(6), 1991
PMID: 1664909
Human leukocyte collagenase: characterization of enzyme kinetics by a new method.
Turto H, Lindy S, Uitto VJ, Wegelius O, Uitto J., Anal. Biochem. 83(2), 1977
PMID: 203207
Human neutrophil collagenase cleaves alpha 1-antitrypsin.
Michaelis J, Vissers MC, Winterbourn CC., Biochem. J. 270(3), 1990
PMID: 2173552
A protease from Bacteriodes gingivalis degrades cell surface and matrix glycoproteins of cultured gingival fibroblasts and induces secretion of collagenase and plasminogen activator
Uitto, Infect Immunol 57(), 1988
A trypsin-like protease from Bacteroides gingivalis: partial purification and characterization.
Sorsa T, Uitto VJ, Suomalainen K, Turto H, Lindy S., J. Periodont. Res. 22(5), 1987
PMID: 2826746
CMT/NSAID combination increases bone CMT uptake and inhibits bone resorption
Ramamurthy, Ann NY Acad Sci 696(), 1993
Tissue destruction by neutrophils.
Weiss SJ., N. Engl. J. Med. 320(6), 1989
PMID: 2536474
Reactive oxygen species activate and tetracyclines inhibit rat osteoblast collagenase.
Ramamurthy NS, Vernillo AT, Greenwald RA, Lee HM, Sorsa T, Golub LM, Rifkin BR., J. Bone Miner. Res. 8(10), 1993
PMID: 8256662
Long-term treatment of reactive arthritis with tetracycline
Lauhio, Progress Rheumatol 6(), 1993
Comparison of doxycycline and chemically modified tetracycline in inhibition of leukocyte functions
Gabler, Res Comm Chem Pathol Pharmacol 78(), 1992
Reactive arthritis-consider combination treatment
Lauhio, Br Med J 308(), 1994
Doxycycline in the protection of serum alpha-1-antitrypsin from human neutrophil collagenase and gelatinase.
Sorsa T, Lindy O, Konttinen YT, Suomalainen K, Ingman T, Saari H, Halinen S, Lee HM, Golub LM, Hall J., Antimicrob. Agents Chemother. 37(3), 1993
PMID: 8384819
The regulatory role of doxycycline/tetracycline in collagenolytic activity and tissue destruction in joint diseases: comment on the article by Yu et al.
Lauhio A, Sorsa T, Lindy O, Suomalainen K, Saari H, Golub LM, Konttinen YT., Arthritis Rheum. 36(9), 1993
PMID: 8216431
Placebo-controlled study of the effects of 3-month lymecycline treatment on serum matrix metalloproteinase in reactive arthritis
Lauhio, Ann NY Acad Sci (), 1994

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