COLLAGENASE IN SJOGRENS-SYNDROME

KONTTINEN YT, KANGASPUNTA P, LINDY O, TAKAGI M, SORSA T, SEGERBERG M, Tschesche H, EISEN AZ (1994)
ANNALS OF THE RHEUMATIC DISEASES 53(12): 836-839.

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Objective-To study collagenase production in labial salivary glands in patients with Sjogren's syndrome (SS). Methods-Collagenases were localised in labial salivary glands by immunohistochemistry. Collagenase activity against triple helical type I collagen monomers in stimulated saliva was measured using sodium dodecyl sulphate polyacrylamide gel electrophoresis and laser densitometry; tissue inhibitor metalloproteinase (TIMP) was measured by enzyme Linked immunosorbent assay. Results-Cells containing collagenase of matrix metalloproteinase (MMP)-1 type were more frequent and more intensely staining in SS than in healthy glands. Only SS saliva contained functional enzyme (11.7 (6.8) x 10(-6) IU/1). Cells containing MMP-8 type neutrophil collagenase were not found in situ, which was in accordance with sialochemical findings/doxycycline inhibition studies. TIMP was found in both SS and normal saliva. Conclusions-Fibroblast, but not neutrophil type, collagenase is synthesised, secreted, and subsequently activated, but is not inhibited by TIMP in labial salivary glands or saliva in SS. Collagenase may destroy glandular and salivary duct tissue and perturb factors influencing the morphogenetic extracellular matrix.
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KONTTINEN YT, KANGASPUNTA P, LINDY O, et al. COLLAGENASE IN SJOGRENS-SYNDROME. ANNALS OF THE RHEUMATIC DISEASES. 1994;53(12):836-839.
KONTTINEN, Y. T., KANGASPUNTA, P., LINDY, O., TAKAGI, M., SORSA, T., SEGERBERG, M., Tschesche, H., et al. (1994). COLLAGENASE IN SJOGRENS-SYNDROME. ANNALS OF THE RHEUMATIC DISEASES, 53(12), 836-839. doi:10.1136/ard.53.12.836
KONTTINEN, Y. T., KANGASPUNTA, P., LINDY, O., TAKAGI, M., SORSA, T., SEGERBERG, M., Tschesche, H., and EISEN, A. Z. (1994). COLLAGENASE IN SJOGRENS-SYNDROME. ANNALS OF THE RHEUMATIC DISEASES 53, 836-839.
KONTTINEN, Y.T., et al., 1994. COLLAGENASE IN SJOGRENS-SYNDROME. ANNALS OF THE RHEUMATIC DISEASES, 53(12), p 836-839.
Y.T. KONTTINEN, et al., “COLLAGENASE IN SJOGRENS-SYNDROME”, ANNALS OF THE RHEUMATIC DISEASES, vol. 53, 1994, pp. 836-839.
KONTTINEN, Y.T., KANGASPUNTA, P., LINDY, O., TAKAGI, M., SORSA, T., SEGERBERG, M., Tschesche, H., EISEN, A.Z.: COLLAGENASE IN SJOGRENS-SYNDROME. ANNALS OF THE RHEUMATIC DISEASES. 53, 836-839 (1994).
KONTTINEN, YT, KANGASPUNTA, P, LINDY, O, TAKAGI, M, SORSA, T, SEGERBERG, M, Tschesche, Harald, and EISEN, AZ. “COLLAGENASE IN SJOGRENS-SYNDROME”. ANNALS OF THE RHEUMATIC DISEASES 53.12 (1994): 836-839.
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Increase in acrolein-conjugated immunoglobulins in saliva from patients with primary Sjögren's syndrome.
Hirose T, Saiki R, Uemura T, Suzuki T, Dohmae N, Ito S, Takahashi H, Ishii I, Toida T, Kashiwagi K, Igarashi K., Clin Chim Acta 450(), 2015
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PMID: 23138733
Intense correlation between protein-conjugated acrolein and primary Sjögren's syndrome.
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PMID: 11092531
72-kDa and 92-kDa gelatinases in saliva of patients with human immunodeficiency virus infection.
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The activation and function of host matrix metalloproteinases in dentin matrix breakdown in caries lesions.
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Matrix metalloproteinase (MMP)-9 type IV collagenase/gelatinase implicated in the pathogenesis of Sjögren's syndrome.
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PMID: 9822200

10 References

Data provided by Europe PubMed Central.

The Copenhagen criteria for Sjogren's syndrome.
Manthorpe R, Oxholm P, Prause JU, Schiodt M., Scand. J. Rheumatol. Suppl. 61(), 1986
PMID: 3473631
Human fibroblast collagenase. Complete primary structure and homology to an oncogene transformation-induced rat protein.
Goldberg GI, Wilhelm SM, Kronberger A, Bauer EA, Grant GA, Eisen AZ., J. Biol. Chem. 261(14), 1986
PMID: 3009463
Human neutrophil collagenase. A distinct gene product with homology to other matrix metalloproteinases.
Hasty KA, Pourmotabbed TF, Goldberg GI, Thompson JP, Spinella DG, Stevens RM, Mainardi CL., J. Biol. Chem. 265(20), 1990
PMID: 2164002
Human neutrophil collagenase cleaves alpha 1-antitrypsin.
Michaelis J, Vissers MC, Winterbourn CC., Biochem. J. 270(3), 1990
PMID: 2173552
Human leukocyte collagenase: characterization of enzyme kinetics by a new method.
Turto H, Lindy S, Uitto VJ, Wegelius O, Uitto J., Anal. Biochem. 83(2), 1977
PMID: 203207
Specificity of the anticollagenase action of tetracyclines: relevance to their anti-inflammatory potential.
Suomalainen K, Sorsa T, Golub LM, Ramamurthy N, Lee HM, Uitto VJ, Saari H, Konttinen YT., Antimicrob. Agents Chemother. 36(1), 1992
PMID: 1317148

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