INTERLEUKIN-8 SYNTHESIS AND THE ONSET OF LABOR

OSMERS RGW, BLASER J, KUHN W, Tschesche H (1995)
OBSTETRICS AND GYNECOLOGY 86(2): 223-229.

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Abstract
Objective: To examine the role of cytokines in cervical dilation. Methods: In 55 patients undergoing cesarean delivery, we took samples from the lower uterine segment, the decidua, and the membranes. We determined the concentrations of interleukin (IL)-2, IL-8, tumor necrosis factor-alpha, matrix metalloproteinase (MMP)-8, and MMP-9 in the different tissues. Results: Depending on the state of labor, we observed a significant increase (P < .001) in IL-8 concentrations in the lower uterine segment. The leukocyte enzymes MMP-8 and MMP-9 were highly significantly correlated with the IL-8 concentrations. Conclusion: Interleukin-8 is critically involved in the process of parturition in humans. Interleukin-6 concentrations in the myometrium, decidua, and membranes correlated strongly with the observed MMP-8 and MMP-9 concentrations.
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OSMERS RGW, BLASER J, KUHN W, Tschesche H. INTERLEUKIN-8 SYNTHESIS AND THE ONSET OF LABOR. OBSTETRICS AND GYNECOLOGY. 1995;86(2):223-229.
OSMERS, R. G. W., BLASER, J., KUHN, W., & Tschesche, H. (1995). INTERLEUKIN-8 SYNTHESIS AND THE ONSET OF LABOR. OBSTETRICS AND GYNECOLOGY, 86(2), 223-229. doi:10.1016/0029-7844(95)93704-4
OSMERS, R. G. W., BLASER, J., KUHN, W., and Tschesche, H. (1995). INTERLEUKIN-8 SYNTHESIS AND THE ONSET OF LABOR. OBSTETRICS AND GYNECOLOGY 86, 223-229.
OSMERS, R.G.W., et al., 1995. INTERLEUKIN-8 SYNTHESIS AND THE ONSET OF LABOR. OBSTETRICS AND GYNECOLOGY, 86(2), p 223-229.
R.G.W. OSMERS, et al., “INTERLEUKIN-8 SYNTHESIS AND THE ONSET OF LABOR”, OBSTETRICS AND GYNECOLOGY, vol. 86, 1995, pp. 223-229.
OSMERS, R.G.W., BLASER, J., KUHN, W., Tschesche, H.: INTERLEUKIN-8 SYNTHESIS AND THE ONSET OF LABOR. OBSTETRICS AND GYNECOLOGY. 86, 223-229 (1995).
OSMERS, RGW, BLASER, J, KUHN, W, and Tschesche, Harald. “INTERLEUKIN-8 SYNTHESIS AND THE ONSET OF LABOR”. OBSTETRICS AND GYNECOLOGY 86.2 (1995): 223-229.
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