EVIDENCE FOR THE TISSUE INHIBITOR OF METALLOPROTEINASES-1 (TIMP-1) IN HUMAN POLYMORPHONUCLEAR LEUKOCYTES

TRIEBEL S, BLASER J, GOTE T, PELZ G, SCHUREN E, SCHMITT M, Tschesche H (1995)
EUROPEAN JOURNAL OF BIOCHEMISTRY 231(3): 714-719.

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A tissue inhibitor of metalloproteinases (TIMP)-1 was isolated from human polymorphonuclear leukocytes (PMNL) in a complex with latent 95-kDa gelatinase (matrixmetalloproteinase, MMP-9). It was separated from the enzyme by gel fitration in the presence of SDS. Using a competitive ELISA procedure, we determined that 10% of the isolated gelatinase was complexed with TIMP-1. The presence of the inhibitor in isolated PMNL could also be demonstrated by indirect immunofluorescence using a specific antibody against TIMP-1. Cellular mRNA was isolated from PMNL, which were highly purified by separation via formylMet-Leu-Pro-stimulated chemotactic migration in a Boyden chamber. Using reverse-transcription PCR and Northern blotting, TIMP-1 mRNA was shown to be present in PMNL, suggesting that these cells are also capable of synthesizing TIMP-1.
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TRIEBEL S, BLASER J, GOTE T, et al. EVIDENCE FOR THE TISSUE INHIBITOR OF METALLOPROTEINASES-1 (TIMP-1) IN HUMAN POLYMORPHONUCLEAR LEUKOCYTES. EUROPEAN JOURNAL OF BIOCHEMISTRY. 1995;231(3):714-719.
TRIEBEL, S., BLASER, J., GOTE, T., PELZ, G., SCHUREN, E., SCHMITT, M., & Tschesche, H. (1995). EVIDENCE FOR THE TISSUE INHIBITOR OF METALLOPROTEINASES-1 (TIMP-1) IN HUMAN POLYMORPHONUCLEAR LEUKOCYTES. EUROPEAN JOURNAL OF BIOCHEMISTRY, 231(3), 714-719.
TRIEBEL, S., BLASER, J., GOTE, T., PELZ, G., SCHUREN, E., SCHMITT, M., and Tschesche, H. (1995). EVIDENCE FOR THE TISSUE INHIBITOR OF METALLOPROTEINASES-1 (TIMP-1) IN HUMAN POLYMORPHONUCLEAR LEUKOCYTES. EUROPEAN JOURNAL OF BIOCHEMISTRY 231, 714-719.
TRIEBEL, S., et al., 1995. EVIDENCE FOR THE TISSUE INHIBITOR OF METALLOPROTEINASES-1 (TIMP-1) IN HUMAN POLYMORPHONUCLEAR LEUKOCYTES. EUROPEAN JOURNAL OF BIOCHEMISTRY, 231(3), p 714-719.
S. TRIEBEL, et al., “EVIDENCE FOR THE TISSUE INHIBITOR OF METALLOPROTEINASES-1 (TIMP-1) IN HUMAN POLYMORPHONUCLEAR LEUKOCYTES”, EUROPEAN JOURNAL OF BIOCHEMISTRY, vol. 231, 1995, pp. 714-719.
TRIEBEL, S., BLASER, J., GOTE, T., PELZ, G., SCHUREN, E., SCHMITT, M., Tschesche, H.: EVIDENCE FOR THE TISSUE INHIBITOR OF METALLOPROTEINASES-1 (TIMP-1) IN HUMAN POLYMORPHONUCLEAR LEUKOCYTES. EUROPEAN JOURNAL OF BIOCHEMISTRY. 231, 714-719 (1995).
TRIEBEL, S, BLASER, J, GOTE, T, PELZ, G, SCHUREN, E, SCHMITT, M, and Tschesche, Harald. “EVIDENCE FOR THE TISSUE INHIBITOR OF METALLOPROTEINASES-1 (TIMP-1) IN HUMAN POLYMORPHONUCLEAR LEUKOCYTES”. EUROPEAN JOURNAL OF BIOCHEMISTRY 231.3 (1995): 714-719.
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