STRUCTURE DETERMINATION AND ANALYSIS OF HUMAN NEUTROPHIL COLLAGENASE COMPLEXED WITH A HYDROXAMATE INHIBITOR

GRAMS F, CRIMMIN M, HINNES L, HUXLEY P, PIEPER M, Tschesche H, BODE W (1995)
BIOCHEMISTRY 34(43): 14012-14020.

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Abstract
Matrix metalloproteinases are a family of zinc endopeptidases involved in tissue remodeling. They have been implicated in various disease processes including metastasis, joint destruction, and neurodegeneration, Human neutrophil collagenase (HNC, MMP-8) represents one of the three ''interstitial'' collagenases that cleave triple-helical collagens types I, II, and III. Its 163-residue catalytic domain (Met80 to Gly242) has been expressed in Escherichia coli and crystallized as a noncovalent complex with the hydroxamate inhibitor batimastat. The crystal structure, refined to 2.1 Angstrom, demonstrates that batimastat binds to the S1-S2' sites and coordinates to the catalytic zinc in a bidentate manner via the hydroxyl and carbonyl oxygens of the hydroxamate group. The batimastat-collagenase complex is described in detail, and the activities of batimastat analogues are discussed in the light of the protein-inhibitor interactions revealed by the crystallography studies,
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GRAMS F, CRIMMIN M, HINNES L, et al. STRUCTURE DETERMINATION AND ANALYSIS OF HUMAN NEUTROPHIL COLLAGENASE COMPLEXED WITH A HYDROXAMATE INHIBITOR. BIOCHEMISTRY. 1995;34(43):14012-14020.
GRAMS, F., CRIMMIN, M., HINNES, L., HUXLEY, P., PIEPER, M., Tschesche, H., & BODE, W. (1995). STRUCTURE DETERMINATION AND ANALYSIS OF HUMAN NEUTROPHIL COLLAGENASE COMPLEXED WITH A HYDROXAMATE INHIBITOR. BIOCHEMISTRY, 34(43), 14012-14020.
GRAMS, F., CRIMMIN, M., HINNES, L., HUXLEY, P., PIEPER, M., Tschesche, H., and BODE, W. (1995). STRUCTURE DETERMINATION AND ANALYSIS OF HUMAN NEUTROPHIL COLLAGENASE COMPLEXED WITH A HYDROXAMATE INHIBITOR. BIOCHEMISTRY 34, 14012-14020.
GRAMS, F., et al., 1995. STRUCTURE DETERMINATION AND ANALYSIS OF HUMAN NEUTROPHIL COLLAGENASE COMPLEXED WITH A HYDROXAMATE INHIBITOR. BIOCHEMISTRY, 34(43), p 14012-14020.
F. GRAMS, et al., “STRUCTURE DETERMINATION AND ANALYSIS OF HUMAN NEUTROPHIL COLLAGENASE COMPLEXED WITH A HYDROXAMATE INHIBITOR”, BIOCHEMISTRY, vol. 34, 1995, pp. 14012-14020.
GRAMS, F., CRIMMIN, M., HINNES, L., HUXLEY, P., PIEPER, M., Tschesche, H., BODE, W.: STRUCTURE DETERMINATION AND ANALYSIS OF HUMAN NEUTROPHIL COLLAGENASE COMPLEXED WITH A HYDROXAMATE INHIBITOR. BIOCHEMISTRY. 34, 14012-14020 (1995).
GRAMS, F, CRIMMIN, M, HINNES, L, HUXLEY, P, PIEPER, M, Tschesche, Harald, and BODE, W. “STRUCTURE DETERMINATION AND ANALYSIS OF HUMAN NEUTROPHIL COLLAGENASE COMPLEXED WITH A HYDROXAMATE INHIBITOR”. BIOCHEMISTRY 34.43 (1995): 14012-14020.
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