Concentration of different proteolytic and angiogenic factors in plasma and placenta extract of patients with HELLP syndrome, pre-/eclampsia, and highly pathological Doppler flow measurements

Kolben M, Lopens A, Blaser J, Huber A, Frank M, Wilhelm O, Wilhelm S, Schneider KTM, Ulm K, Tschesche H, Schmitt M, et al. (1995)
In: GYNAKOLOGISCH-GEBURTSHILFLICHE RUNDSCHAU. 35. KARGER: 126-131.

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Objective: Impaired trophoblast invasion plays a major role in the development of preeclampsia. Therefore various factors that are involved in invasion were investigated in gestational disease. Methods: In pregnant women with HELLP-syndrome (n = 18), pre-/eclampsia (n = 21) and highly pathological Doppler flow measurements (hpD) (n = 13), plasma and placental tissue extract concentrations of uPA, uPA-receptor, tPA, PAI-1, MMP-8, MMP-9, TIMP-1, thrombomodulin, and angiogenin were measured using ELISA. Results: In all three collectives, PAI-1 plasma concentrations were significantly higher (p < 0,05) than in normal pregnancies, in patients with HELLP-syndrome, tPA and TIMP-1 plasma levels were also elevated. MMP-9 concentrations in placental tissue extracts were lower in pre-/eclampsia than in normal pregnancies. Conclusions: Impaired placental implantation and remodelling in gestational disease is reflected by changes in plasma and placental tissue extract concentrations of various factors that are involved in these processes.
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Kolben M, Lopens A, Blaser J, et al. Concentration of different proteolytic and angiogenic factors in plasma and placenta extract of patients with HELLP syndrome, pre-/eclampsia, and highly pathological Doppler flow measurements. In: GYNAKOLOGISCH-GEBURTSHILFLICHE RUNDSCHAU. Vol 35. KARGER; 1995: 126-131.
Kolben, M., Lopens, A., Blaser, J., Huber, A., Frank, M., Wilhelm, O., Wilhelm, S., et al. (1995). Concentration of different proteolytic and angiogenic factors in plasma and placenta extract of patients with HELLP syndrome, pre-/eclampsia, and highly pathological Doppler flow measurements. GYNAKOLOGISCH-GEBURTSHILFLICHE RUNDSCHAU, 35, 126-131.
Kolben, M., Lopens, A., Blaser, J., Huber, A., Frank, M., Wilhelm, O., Wilhelm, S., Schneider, K. T. M., Ulm, K., Tschesche, H., et al. (1995). “Concentration of different proteolytic and angiogenic factors in plasma and placenta extract of patients with HELLP syndrome, pre-/eclampsia, and highly pathological Doppler flow measurements” in GYNAKOLOGISCH-GEBURTSHILFLICHE RUNDSCHAU, vol. 35, (KARGER), 126-131.
Kolben, M., et al., 1995. Concentration of different proteolytic and angiogenic factors in plasma and placenta extract of patients with HELLP syndrome, pre-/eclampsia, and highly pathological Doppler flow measurements. In GYNAKOLOGISCH-GEBURTSHILFLICHE RUNDSCHAU. no.35 KARGER, pp. 126-131.
M. Kolben, et al., “Concentration of different proteolytic and angiogenic factors in plasma and placenta extract of patients with HELLP syndrome, pre-/eclampsia, and highly pathological Doppler flow measurements”, GYNAKOLOGISCH-GEBURTSHILFLICHE RUNDSCHAU, vol. 35, KARGER, 1995, pp.126-131.
Kolben, M., Lopens, A., Blaser, J., Huber, A., Frank, M., Wilhelm, O., Wilhelm, S., Schneider, K.T.M., Ulm, K., Tschesche, H., Schmitt, M., Graeff, H.: Concentration of different proteolytic and angiogenic factors in plasma and placenta extract of patients with HELLP syndrome, pre-/eclampsia, and highly pathological Doppler flow measurements. GYNAKOLOGISCH-GEBURTSHILFLICHE RUNDSCHAU. 35, p. 126-131. KARGER (1995).
Kolben, M, Lopens, A, Blaser, J, Huber, A, Frank, M, Wilhelm, O, Wilhelm, S, Schneider, KTM, Ulm, K, Tschesche, Harald, Schmitt, M, and Graeff, H. “Concentration of different proteolytic and angiogenic factors in plasma and placenta extract of patients with HELLP syndrome, pre-/eclampsia, and highly pathological Doppler flow measurements”. GYNAKOLOGISCH-GEBURTSHILFLICHE RUNDSCHAU. KARGER, 1995.Vol. 35. 126-131.
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Protein profiling of preeclampsia placental tissues.
Shu C, Liu Z, Cui L, Wei C, Wang S, Tang JJ, Cui M, Lian G, Li W, Liu X, Xu H, Jiang J, Lee P, Zhang DY, He J, Ye F., PLoS ONE 9(11), 2014
PMID: 25392996
Molecular mechanisms of preeclampsia.
Mutter WP, Karumanchi SA., Microvasc. Res. 75(1), 2008
PMID: 17553534

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