Expression of matrix-metalloproteinases and their inhibitors in human cholesteatomas

Schonermark M, Mester B, Kempf HG, Blaser J, Tschesche H, Lenarz T (1996)
ACTA OTO-LARYNGOLOGICA 116(3): 451-456.

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The proteolytic erosion of the temporal bone is the key event in the pathognomonic course of cholesteatoma progression. The molecular mechanisms of bone resorption, endangering the ossicles, the inner ear, the facial nerve, large vessels or the brain, are not understood. Recently, a new family of proteolytic enzymes, the matrix-metalloproteinases (MMP's) has been described and identified, which seems to play a pivotal role in matrix- and bone homeostasis and inflammatory osteolytic diseases, e.g. osteoarthritis and periodontitis. These enzymes are sophisticatedly controlled by specific inhibitors and activation cascades. We investigated whether human cholesteatoma tissue expresses MMP's and MMP-inhibitors. By immunocytochemistry of cholesteatoma-cryosections, the expression of MMP-2 (72 kD collagenase), MMP-9 (92 kD collagenase), and MMP-3 (stromelysin-1) could be seen to be strictly confined to the basal and suprabasal cell layer of the cholesteatoma epithelium. The neutrophil collagenase (MMP-1) showed a more disseminated expression in the epithelium and the granulation tissue as well. The tissue inhibitor of metalloproteases, TIMP-1, could be detected only in very limited areas of the granulation tissue in a quite randomized manner. Therefore, a derailment in favor of proteolysis of the normally tightly controlled MMP-system might be postulated. The results indicate that members of the MMP-family could play an active role in the molecular mechanisms of cholesteatoma invasion into the temporal bone. This offers new insights into the pathophysiology of the disease and of potential therapeutic approaches.
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Schonermark M, Mester B, Kempf HG, Blaser J, Tschesche H, Lenarz T. Expression of matrix-metalloproteinases and their inhibitors in human cholesteatomas. ACTA OTO-LARYNGOLOGICA. 1996;116(3):451-456.
Schonermark, M., Mester, B., Kempf, H. G., Blaser, J., Tschesche, H., & Lenarz, T. (1996). Expression of matrix-metalloproteinases and their inhibitors in human cholesteatomas. ACTA OTO-LARYNGOLOGICA, 116(3), 451-456. doi:10.3109/00016489609137872
Schonermark, M., Mester, B., Kempf, H. G., Blaser, J., Tschesche, H., and Lenarz, T. (1996). Expression of matrix-metalloproteinases and their inhibitors in human cholesteatomas. ACTA OTO-LARYNGOLOGICA 116, 451-456.
Schonermark, M., et al., 1996. Expression of matrix-metalloproteinases and their inhibitors in human cholesteatomas. ACTA OTO-LARYNGOLOGICA, 116(3), p 451-456.
M. Schonermark, et al., “Expression of matrix-metalloproteinases and their inhibitors in human cholesteatomas”, ACTA OTO-LARYNGOLOGICA, vol. 116, 1996, pp. 451-456.
Schonermark, M., Mester, B., Kempf, H.G., Blaser, J., Tschesche, H., Lenarz, T.: Expression of matrix-metalloproteinases and their inhibitors in human cholesteatomas. ACTA OTO-LARYNGOLOGICA. 116, 451-456 (1996).
Schonermark, M, Mester, B, Kempf, HG, Blaser, J, Tschesche, Harald, and Lenarz, T. “Expression of matrix-metalloproteinases and their inhibitors in human cholesteatomas”. ACTA OTO-LARYNGOLOGICA 116.3 (1996): 451-456.
This data publication is cited in the following publications:
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19 Citations in Europe PMC

Data provided by Europe PubMed Central.

Pathogenesis and Bone Resorption in Acquired Cholesteatoma: Current Knowledge and Future Prospectives.
Hamed MA, Nakata S, Sayed RH, Ueda H, Badawy BS, Nishimura Y, Kojima T, Iwata N, Ahmed AR, Dahy K, Kondo N, Suzuki K., Clin Exp Otorhinolaryngol 9(4), 2016
PMID: 27440129
Increased permeability of the epithelium of middle ear cholesteatoma.
Koizumi H, Suzuki H, Ohbuchi T, Kitamura T, Hashida K, Nakamura M., Clin Otolaryngol 40(2), 2015
PMID: 25319490
Possible participation of acidic pH in bone resorption in middle ear cholesteatoma.
Nguyen KH, Suzuki H, Ohbuchi T, Wakasugi T, Koizumi H, Hashida K, Baba R, Morimoto H, Doi Y., Laryngoscope 124(1), 2014
PMID: 24122656
Cholesteatoma-associated fibroblasts modulate epithelial growth and differentiation through KGF/FGF7 secretion.
Raffa S, Leone L, Scrofani C, Monini S, Torrisi MR, Barbara M., Histochem Cell Biol 138(2), 2012
PMID: 22481617
Elevated level of tenascin and matrix metalloproteinase 9 correlates with the bone destruction capacity of cholesteatomas.
Juhász A, Sziklai I, Rákosy Z, Ecsedi S, Adány R, Balázs M., Otol Neurotol 30(4), 2009
PMID: 19395987
[Pathology of the ear].
Wassef M., Ann Pathol 29(4), 2009
PMID: 19900639
The role of inflammatory mediators in the pathogenesis of otitis media and sequelae.
Juhn SK, Jung MK, Hoffman MD, Drew BR, Preciado DA, Sausen NJ, Jung TT, Kim BH, Park SY, Lin J, Ondrey FG, Mains DR, Huang T., Clin Exp Otorhinolaryngol 1(3), 2008
PMID: 19434244
The pathophysiology of cholesteatoma.
Semaan MT, Megerian CA., Otolaryngol Clin North Am 39(6), 2006
PMID: 17097438
Gene expression analysis of human middle ear cholesteatoma using complementary DNA arrays.
Tokuriki M, Noda I, Saito T, Narita N, Sunaga H, Tsuzuki H, Ohtsubo T, Fujieda S, Saito H., Laryngoscope 113(5), 2003
PMID: 12792315
Inhibition of matrix metalloproteinases in gerbil cholesteatoma: preliminary findings.
Lehman DA, Wilmoth JG, Prevatt AR, Schultz GS, Antonelli PJ., Otolaryngol Head Neck Surg 126(4), 2002
PMID: 11997781
Expression of matrix-degrading cysteine proteinase cathepsin K in cholesteatoma.
Hansen T, Unger RE, Gaumann A, Hundorf I, Maurer J, Kirkpatrick CJ, Kriegsmann J., Mod Pathol 14(12), 2001
PMID: 11743044
Structural changes and protein expression in the mastoid bone adjacent to cholesteatoma.
Cinamon U, Kronenberg J, Benayahu D., Laryngoscope 110(7), 2000
PMID: 10892696
Origin and spread of allergic fungal disease of the nose and paranasal sinuses.
Michaels L, Lloyd G, Phelps P., Clin Otolaryngol Allied Sci 25(6), 2000
PMID: 11122292
Expression pattern of the plasminogen activator-plasmin system in human cholesteatoma.
Schönermark MP, Issing PR, Erbrich BK, Lenarz T., Ann Otol Rhinol Laryngol 108(3), 1999
PMID: 10086616
Matrix metalloproteinase-2 and matrix metalloproteinase-9 in cholesteatoma and deep meatal skin.
Banerjee AR, James R, Narula AA., Clin Otolaryngol Allied Sci 23(4), 1998
PMID: 9762497
Matrix metalloproteinase-1 in cholesteatoma, middle ear granulations and deep meatal skin: a comparative analysis.
Banerjee AR, James R, Narula AA, Lee RJ., Clin Otolaryngol Allied Sci 23(6), 1998
PMID: 9884804

25 References

Data provided by Europe PubMed Central.

Collagenolytic activity in middle ear cholesteatoma.
Abramson M., Ann. Otol. Rhinol. Laryngol. 78(1), 1969
PMID: 4303159
Matrix metalloproteinases: a review.
Birkedal-Hansen H, Moore WG, Bodden MK, Windsor LJ, Birkedal-Hansen B, DeCarlo A, Engler JA., Crit. Rev. Oral Biol. Med. 4(2), 1993
PMID: 8435466

Murphy, Ann NY Acad Sci 732(), 1994
Extracellular matrix 6: role of matrix metalloproteinases in tumor invasion and metastasis.
Stetler-Stevenson WG, Liotta LA, Kleiner DE Jr., FASEB J. 7(15), 1993
PMID: 8262328

McCulloch, Ann NY Acad Sci 732(), 1994
Clinical importance of metalloproteinases and their inhibitors.
Krane SM., Ann. N. Y. Acad. Sci. 732(), 1994
PMID: 7978783

Vaes, Matrix (), 1992
Enzyme linked immunosorbent assays (ELISA) for the quantitative determination of human leukocyte collagenase and gelatinase.
Bergmann U, Michaelis J, Oberhoff R, Knauper V, Beckmann R, Tschesche H., J. Clin. Chem. Clin. Biochem. 27(6), 1989
PMID: 2547014
A semicontinuous, high-performance liquid chromatography-based assay for stromelysin.
Harrison R, Teahan J, Stein R., Anal. Biochem. 180(1), 1989
PMID: 2479283

Enghild, J Biol Chem 264(), 1989
Degradation of basement membranes by human matrix metalloproteinase 3 (stromelysin).
Bejarano PA, Noelken ME, Suzuki K, Hudson BG, Nagase H., Biochem. J. 256(2), 1988
PMID: 3223920

Lang, Laryngorhinotologie 73(), 1994

AUTHOR UNKNOWN, 0
Localization of interleukin-1 in human cholesteatoma.
Ahn JM, Huang CC, Abramson M., Am J Otolaryngol 11(2), 1990
PMID: 2188520

Dallari, Acta Otolaryngol (Stockh) 114(), 1994
Action of collagenase and elastase from human polymorphonuclear leukocytes on human articular cartilage.
Baici A, Salgam P, Cohen G, Fehr K, Boni A., Rheumatol. Int. 2(1), 1982
PMID: 6294813
Modulation of bone resorption by tetracyclines.
Rifkin BR, Vernillo AT, Golub LM, Ramamurthy NS., Ann. N. Y. Acad. Sci. 732(), 1994
PMID: 7978789

Woessner, J Rheumatol 18(), 1991

Buttice, Nucleic Acids Res 13(), 1991

Moriyama, Arch Otorhinolaryngol 230(), 1984

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