A Corynebacterium glutamicum gene encoding a two-domain protein similar to biotin carboxylases and biotin-carboxyl-carrier proteins

Jäger W, Peters-Wendisch P, Kalinowski J, Pühler A (1996)
Arch Microbiol 166(2): 76-82.

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Abstract
Following the analysis of transposon Tn5432-induced mutants of Corynebacterium glutamicum ATCC 13032, a gene encoding a protein with a biotin-binding motif was cloned. The DNA sequence of this gene revealed an open reading frame encoding 591 amino acids with a calculated mol. mass of 63.4 kDa. The protein is composed of two domains, an N-terminal biotin carboxylase and a C-terminal biotin-carboxyl-carrier protein, that are highly similar to corresponding subunits from prokaryotic and eukaryotic biotin enzymes. Over 70% identity was found to a protein from Mycobacterium leprae proposed to be part of an acyl-CoA carboxylase. Since it was not possible to inactivate the C. glutamicum gene, the gene most likely encodes a subunit of the essential acetyl-CoA carboxylase, which catalyzes the committed step in fatty acid synthesis.
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Jäger W, Peters-Wendisch P, Kalinowski J, Pühler A. A Corynebacterium glutamicum gene encoding a two-domain protein similar to biotin carboxylases and biotin-carboxyl-carrier proteins. Arch Microbiol. 1996;166(2):76-82.
Jäger, W., Peters-Wendisch, P., Kalinowski, J., & Pühler, A. (1996). A Corynebacterium glutamicum gene encoding a two-domain protein similar to biotin carboxylases and biotin-carboxyl-carrier proteins. Arch Microbiol, 166(2), 76-82.
Jäger, W., Peters-Wendisch, P., Kalinowski, J., and Pühler, A. (1996). A Corynebacterium glutamicum gene encoding a two-domain protein similar to biotin carboxylases and biotin-carboxyl-carrier proteins. Arch Microbiol 166, 76-82.
Jäger, W., et al., 1996. A Corynebacterium glutamicum gene encoding a two-domain protein similar to biotin carboxylases and biotin-carboxyl-carrier proteins. Arch Microbiol, 166(2), p 76-82.
W. Jäger, et al., “A Corynebacterium glutamicum gene encoding a two-domain protein similar to biotin carboxylases and biotin-carboxyl-carrier proteins”, Arch Microbiol, vol. 166, 1996, pp. 76-82.
Jäger, W., Peters-Wendisch, P., Kalinowski, J., Pühler, A.: A Corynebacterium glutamicum gene encoding a two-domain protein similar to biotin carboxylases and biotin-carboxyl-carrier proteins. Arch Microbiol. 166, 76-82 (1996).
Jäger, W, Peters-Wendisch, Petra, Kalinowski, Jörn, and Pühler, Alfred. “A Corynebacterium glutamicum gene encoding a two-domain protein similar to biotin carboxylases and biotin-carboxyl-carrier proteins”. Arch Microbiol 166.2 (1996): 76-82.
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Engineering biotin prototrophic Corynebacterium glutamicum strains for amino acid, diamine and carotenoid production.
Peters-Wendisch P, Gotker S, Heider SA, Komati Reddy G, Nguyen AQ, Stansen KC, Wendisch VF., J. Biotechnol. 192 Pt B(), 2014
PMID: 24486440
Development of fatty acid-producing Corynebacterium glutamicum strains.
Takeno S, Takasaki M, Urabayashi A, Mimura A, Muramatsu T, Mitsuhashi S, Ikeda M., Appl. Environ. Microbiol. 79(21), 2013
PMID: 23995924
Characterization of the biotin uptake system encoded by the biotin-inducible bioYMN operon of Corynebacterium glutamicum.
Schneider J, Peters-Wendisch P, Stansen KC, Gotker S, Maximow S, Kramer R, Wendisch VF., BMC Microbiol. 12(), 2012
PMID: 22243621
Biotin protein ligase from Corynebacterium glutamicum: role for growth and L: -lysine production.
Peters-Wendisch P, Stansen KC, Gotker S, Wendisch VF., Appl. Microbiol. Biotechnol. 93(6), 2012
PMID: 22159614
Regulation of ldh expression during biotin-limited growth of Corynebacterium glutamicum.
Dietrich C, Nato A, Bost B, Le Marechal P, Guyonvarch A., Microbiology (Reading, Engl.) 155(Pt 4), 2009
PMID: 19332837
The two carboxylases of Corynebacterium glutamicum essential for fatty acid and mycolic acid synthesis.
Gande R, Dover LG, Krumbach K, Besra GS, Sahm H, Oikawa T, Eggeling L., J. Bacteriol. 189(14), 2007
PMID: 17483212
Gene expression of Corynebacterium glutamicum in response to the conditions inducing glutamate overproduction.
Kataoka M, Hashimoto KI, Yoshida M, Nakamatsu T, Horinouchi S, Kawasaki H., Lett. Appl. Microbiol. 42(5), 2006
PMID: 16620205
Rational design of a Corynebacterium glutamicum pantothenate production strain and its characterization by metabolic flux analysis and genome-wide transcriptional profiling.
Huser AT, Chassagnole C, Lindley ND, Merkamm M, Guyonvarch A, Elisakova V, Patek M, Kalinowski J, Brune I, Puhler A, Tauch A., Appl. Environ. Microbiol. 71(6), 2005
PMID: 15933028
Development of a Corynebacterium glutamicum DNA microarray and validation by genome-wide expression profiling during growth with propionate as carbon source.
Huser AT, Becker A, Brune I, Dondrup M, Kalinowski J, Plassmeier J, Puhler A, Wiegrabe I, Tauch A., J. Biotechnol. 106(2-3), 2003
PMID: 14651867

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