Proteases and their inhibitors are indicative in gestational disease

Kolben M, Lopens A, Blaser J, Ulm K, Schmitt M, Schneider KTM, Tschesche H (1996)
EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY 68(1-2): 59-65.

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Abstract
Objective: To assess whether various proteolytic factors which are involved in trophoblast invasion show different concentrations in plasma and placenta of patients with HELLP syndrome, pre-/eclampsia and highly pathological Doppler flow measurements but without additional complications (hpD). Design. Cab control and observational study; 18 women with HELLP syndrome; 21 with pre-/eclampsia, 13 with hpD, as well as healthy pregnant women (matched pairs); statistical analysis: sign test and Wilcoxon test. Results: Urokinase-type plasminogen activator (uPA), uPA receptor, tissue-type plasminogen activator (tPA), plasminogen activator inhibitor 1 (PAI-1), matrix metalloproteinases MMP-8, MMP-9 and tissue inhibitor of metalloproteinases TIMP-1 were measured by ELISA. PAI-1 plasma levels are significantly elevated in all three groups studied. In HELLP syndrome, tPA and TIMP-1 are also elevated, and in patients with hpD, MMP-8 is increased, whereas MMP-9, and TIMP-1 are lower. In placenta extract, only pre-/eclampsia shows reduced MMP-9 concentrations. Conclusions: The increased frequency of small-for-gestational-age infants observed in all three study groups is an expression of impaired placental implantation and remodelling processes. These disturbances manifest themselves in the form of changes in some of the factors in plasma and placenta extract that are involved in these processes.
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Kolben M, Lopens A, Blaser J, et al. Proteases and their inhibitors are indicative in gestational disease. EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY. 1996;68(1-2):59-65.
Kolben, M., Lopens, A., Blaser, J., Ulm, K., Schmitt, M., Schneider, K. T. M., & Tschesche, H. (1996). Proteases and their inhibitors are indicative in gestational disease. EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY, 68(1-2), 59-65.
Kolben, M., Lopens, A., Blaser, J., Ulm, K., Schmitt, M., Schneider, K. T. M., and Tschesche, H. (1996). Proteases and their inhibitors are indicative in gestational disease. EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY 68, 59-65.
Kolben, M., et al., 1996. Proteases and their inhibitors are indicative in gestational disease. EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY, 68(1-2), p 59-65.
M. Kolben, et al., “Proteases and their inhibitors are indicative in gestational disease”, EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY, vol. 68, 1996, pp. 59-65.
Kolben, M., Lopens, A., Blaser, J., Ulm, K., Schmitt, M., Schneider, K.T.M., Tschesche, H.: Proteases and their inhibitors are indicative in gestational disease. EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY. 68, 59-65 (1996).
Kolben, M, Lopens, A, Blaser, J, Ulm, K, Schmitt, M, Schneider, KTM, and Tschesche, Harald. “Proteases and their inhibitors are indicative in gestational disease”. EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY 68.1-2 (1996): 59-65.
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