Liquid secondary ion mass spectrometry of methyl glycosides of oligosaccharides using matrices containing carboxamides

Kovacik V, Hirsch J, Zoric S, Grützmacher H-F (1996)
RAPID COMMUNICATIONS IN MASS SPECTROMETRY 10(13): 1661-1667.

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Abstract
Intense cluster ions corresponding to proton-bound hetero-dimers of an amide molecule and an oligosaccharide molecule are observed in the liquid secondary ion mass spectra of methyl glycosides of oligoxylans if a solution of an aliphatic carboxamide in glycerol is used as the liquid matrix. These cluster ions are particularly abundant and persist for a long period if urea (U) or thiourea (TU) is used as the matrix additive. In these cases, cluster ions containing more than one molecule of U or TU and two oligosaccharide molecules are also observed. The intense signal due to the proton-bound hetero-dimer between U or TU and the oligosaccharide can be used with advantage for a molecular weight determination. The bonding interactions between a protonated saccharide molecule and a molecule U or TU in the proton-bound hetero-dimers are so strong that the urea molecules remain attached to the fragment ions during the decay of metastable cluster ions and even during collision-induced dissociation. Thus, the mass-analysed ion kinetic energy spectra of these proton-bound hetero-dimers are dominated by abundant cluster ions [B-n + U] and [Y-m+ U] arising from cleavage of the glycosidic bonds within the oligosaccharides. The collisionally-activated mass spectra of the proton-bound hetero-dimers additionally contain peaks of the free ions B-n and Y-m. Therefore, these spectra clearly reflect the arrangement of the monosaccharide residues in the oligosaccharide and can be used conveniently for structural analysis.
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Kovacik V, Hirsch J, Zoric S, Grützmacher H-F. Liquid secondary ion mass spectrometry of methyl glycosides of oligosaccharides using matrices containing carboxamides. RAPID COMMUNICATIONS IN MASS SPECTROMETRY. 1996;10(13):1661-1667.
Kovacik, V., Hirsch, J., Zoric, S., & Grützmacher, H. - F. (1996). Liquid secondary ion mass spectrometry of methyl glycosides of oligosaccharides using matrices containing carboxamides. RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 10(13), 1661-1667.
Kovacik, V., Hirsch, J., Zoric, S., and Grützmacher, H. - F. (1996). Liquid secondary ion mass spectrometry of methyl glycosides of oligosaccharides using matrices containing carboxamides. RAPID COMMUNICATIONS IN MASS SPECTROMETRY 10, 1661-1667.
Kovacik, V., et al., 1996. Liquid secondary ion mass spectrometry of methyl glycosides of oligosaccharides using matrices containing carboxamides. RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 10(13), p 1661-1667.
V. Kovacik, et al., “Liquid secondary ion mass spectrometry of methyl glycosides of oligosaccharides using matrices containing carboxamides”, RAPID COMMUNICATIONS IN MASS SPECTROMETRY, vol. 10, 1996, pp. 1661-1667.
Kovacik, V., Hirsch, J., Zoric, S., Grützmacher, H.-F.: Liquid secondary ion mass spectrometry of methyl glycosides of oligosaccharides using matrices containing carboxamides. RAPID COMMUNICATIONS IN MASS SPECTROMETRY. 10, 1661-1667 (1996).
Kovacik, V, Hirsch, J, Zoric, S, and Grützmacher, Hans-Friedrich. “Liquid secondary ion mass spectrometry of methyl glycosides of oligosaccharides using matrices containing carboxamides”. RAPID COMMUNICATIONS IN MASS SPECTROMETRY 10.13 (1996): 1661-1667.
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