The recombinant catalytic domain of membrane-type matrix metalloproteinase-1 (MT1-MMP) induces activation of progelatinase A and progelatinase A complexed with TIMP-2

Lichte A, Kolkenbrock H, Tschesche H (1996)
FEBS LETTERS 397(2-3): 277-282.

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Zeitschriftenaufsatz | Veröffentlicht | Englisch
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Abstract / Bemerkung
A truncated form of the membrane-type matrix metalloproteinase-1 [(Ala(21)-Ile(318))proMT1-MMP] lacking the hemopexin-like and trans-membrane domain was produced in E. coli. We demonstrate that the recombinant proenzyme was autoproteolytically processed to a fully active catalytic domain with N-terminal Ile(114). The catalytic domain of MT1-MMP initiated the activation of progelatinase A and progelatinase A complexed with tissue inhibitor of metalloproteinases-2 (TIMP-2). As a typical soluble metalloproteinase it was able to cleave physiologic as well as synthetic substrates. Our kinetic data demonstrate that TIMP-2 is a potent inhibitor for the recombinant enzyme.
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Zeitschriftentitel
FEBS LETTERS
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397
Zeitschriftennummer
2-3
Seite
277-282
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PUB-ID

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Lichte A, Kolkenbrock H, Tschesche H. The recombinant catalytic domain of membrane-type matrix metalloproteinase-1 (MT1-MMP) induces activation of progelatinase A and progelatinase A complexed with TIMP-2. FEBS LETTERS. 1996;397(2-3):277-282.
Lichte, A., Kolkenbrock, H., & Tschesche, H. (1996). The recombinant catalytic domain of membrane-type matrix metalloproteinase-1 (MT1-MMP) induces activation of progelatinase A and progelatinase A complexed with TIMP-2. FEBS LETTERS, 397(2-3), 277-282. doi:10.1016/S0014-5793(96)01206-9
Lichte, A., Kolkenbrock, H., and Tschesche, H. (1996). The recombinant catalytic domain of membrane-type matrix metalloproteinase-1 (MT1-MMP) induces activation of progelatinase A and progelatinase A complexed with TIMP-2. FEBS LETTERS 397, 277-282.
Lichte, A., Kolkenbrock, H., & Tschesche, H., 1996. The recombinant catalytic domain of membrane-type matrix metalloproteinase-1 (MT1-MMP) induces activation of progelatinase A and progelatinase A complexed with TIMP-2. FEBS LETTERS, 397(2-3), p 277-282.
A. Lichte, H. Kolkenbrock, and H. Tschesche, “The recombinant catalytic domain of membrane-type matrix metalloproteinase-1 (MT1-MMP) induces activation of progelatinase A and progelatinase A complexed with TIMP-2”, FEBS LETTERS, vol. 397, 1996, pp. 277-282.
Lichte, A., Kolkenbrock, H., Tschesche, H.: The recombinant catalytic domain of membrane-type matrix metalloproteinase-1 (MT1-MMP) induces activation of progelatinase A and progelatinase A complexed with TIMP-2. FEBS LETTERS. 397, 277-282 (1996).
Lichte, A, Kolkenbrock, H, and Tschesche, Harald. “The recombinant catalytic domain of membrane-type matrix metalloproteinase-1 (MT1-MMP) induces activation of progelatinase A and progelatinase A complexed with TIMP-2”. FEBS LETTERS 397.2-3 (1996): 277-282.

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PMID: 9088534
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Smine A, Plantner JJ., Curr Eye Res 16(9), 1997
PMID: 9288454

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