Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage

Billinghurst RC, Dahlberg L, Ionescu M, Reiner A, Bourne R, Rorabeck C, Mitchell P, Hambor J, Diekmann O, Tschesche H, Chen J, et al. (1997)
JOURNAL OF CLINICAL INVESTIGATION 99(7): 1534-1545.

Download
No fulltext has been uploaded. References only!
Journal Article | Original Article | Published | English

No fulltext has been uploaded

Author
; ; ; ; ; ; ; ; ; ; ;
All
Abstract / Notes
We demonstrate the direct involvement of increased collagenase activity in the cleavage of type II collagen in osteoarthritic human femoral condylar cartilage by developing and using antibodies reactive to carboxy-terminal (COL2-3/4C(short)) and amino-terminal (COL2-1/4N1) neoepitopes general ed by cleavage of native human type II collagen by collagenase matrix metalloproteinase (MMP)-1 (collagenase-1), MMP-8 (collagenase-2), and MMP-13 (collagenase-3). A secondary cleavage followed the initial cleavage produced by these recombinant collagenases. This generated neoepitope COL2-1/4N2. There was significantly more COL2-3/4C(short) neoepitope in osteoarthritis (OA) compared to adult nonarthritic cartilages as determined by immunoassay of cartilage extracts. A synthetic preferential inhibitor of MMP-13 significantly reduced the unstimulated release in culture of neoepitope COL2-3/4C(short) from human osteoarthritic cartilage explants. These data suggest that collagenase(s) produced by chondrocytes is (are) involved in the cleavage and denaturation of type II collagen in articular cartilage, that this is increased in OA, and that MMP-13 may play a significant role in this process.
Publishing Year
ISSN
PUB-ID

Cite this

Billinghurst RC, Dahlberg L, Ionescu M, et al. Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage. JOURNAL OF CLINICAL INVESTIGATION. 1997;99(7):1534-1545.
Billinghurst, R. C., Dahlberg, L., Ionescu, M., Reiner, A., Bourne, R., Rorabeck, C., Mitchell, P., et al. (1997). Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage. JOURNAL OF CLINICAL INVESTIGATION, 99(7), 1534-1545. doi:10.1172/JCI119316
Billinghurst, R. C., Dahlberg, L., Ionescu, M., Reiner, A., Bourne, R., Rorabeck, C., Mitchell, P., Hambor, J., Diekmann, O., Tschesche, H., et al. (1997). Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage. JOURNAL OF CLINICAL INVESTIGATION 99, 1534-1545.
Billinghurst, R.C., et al., 1997. Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage. JOURNAL OF CLINICAL INVESTIGATION, 99(7), p 1534-1545.
R.C. Billinghurst, et al., “Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage”, JOURNAL OF CLINICAL INVESTIGATION, vol. 99, 1997, pp. 1534-1545.
Billinghurst, R.C., Dahlberg, L., Ionescu, M., Reiner, A., Bourne, R., Rorabeck, C., Mitchell, P., Hambor, J., Diekmann, O., Tschesche, H., Chen, J., VanWart, H., Poole, A.R.: Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage. JOURNAL OF CLINICAL INVESTIGATION. 99, 1534-1545 (1997).
Billinghurst, RC, Dahlberg, L, Ionescu, M, Reiner, A, Bourne, R, Rorabeck, C, Mitchell, P, Hambor, J, Diekmann, O, Tschesche, Harald, Chen, J, VanWart, H, and Poole, AR. “Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage”. JOURNAL OF CLINICAL INVESTIGATION 99.7 (1997): 1534-1545.
This data publication is cited in the following publications:
This publication cites the following data publications:

522 Citations in Europe PMC

Data provided by Europe PubMed Central.

The distribution of YKL-40 in osteoarthritic and normal human articular cartilage.
Volck B, Ostergaard K, Johansen JS, Garbarsch C, Price PA., Scand J Rheumatol 28(3), 1999
PMID: 10380840
Retinoic acid-induced type II collagen degradation does not correlate with matrix metalloproteinase activity in cartilage explant cultures.
Price JS, Wang-Weigand S, Bohne R, Kozaci LD, Hollander AP., Arthritis Rheum 42(1), 1999
PMID: 9920024
Changes in joint cartilage aggrecan after knee injury and in osteoarthritis.
Lohmander LS, Ionescu M, Jugessur H, Poole AR., Arthritis Rheum 42(3), 1999
PMID: 10088777
Resistance of small leucine-rich repeat proteoglycans to proteolytic degradation during interleukin-1-stimulated cartilage catabolism.
Sztrolovics R, White RJ, Poole AR, Mort JS, Roughley PJ., Biochem J 339 ( Pt 3)(), 1999
PMID: 10215595
Potential treatment of osteoarthritis by gene therapy.
Evans CH, Robbins PD., Rheum Dis Clin North Am 25(2), 1999
PMID: 10356421
Serum markers of articular cartilage damage and repair.
Wollheim FA., Rheum Dis Clin North Am 25(2), 1999
PMID: 10356426
Synovial fluid markers in osteoarthritis.
Myers SL., Rheum Dis Clin North Am 25(2), 1999
PMID: 10356427
Type II collagen peptide release from rabbit articular cartilage.
Felice BR, Chichester CO, Barrach HJ., Ann N Y Acad Sci 878(), 1999
PMID: 10415782
Inhibition of articular cartilage degradation in culture by a novel nonpeptidic matrix metalloproteinase inhibitor.
Billinghurst RC, O'Brien K, Poole AR, McIlwraith CW., Ann N Y Acad Sci 878(), 1999
PMID: 10415783
Characterization of collagenase 3 (matrix metalloproteinase 13) messenger RNA expression in the synovial membrane and synovial fibroblasts of patients with rheumatoid arthritis.
Westhoff CS, Freudiger D, Petrow P, Seyfert C, Zacher J, Kriegsmann J, Pap T, Gay S, Stiehl P, Gromnica-Ihle E, Wernicke D., Arthritis Rheum 42(7), 1999
PMID: 10403281
In vitro sensitivity of the three mammalian collagenases to tetracycline inhibition: relationship to bone and cartilage degradation.
Greenwald RA, Golub LM, Ramamurthy NS, Chowdhury M, Moak SA, Sorsa T., Bone 22(1), 1998
PMID: 9437511
Characterization of helical cleavages in type II collagen generated by matrixins.
Vankemmelbeke M, Dekeyser PM, Hollander AP, Buttle DJ, Demeester J., Biochem J 330 ( Pt 2)(), 1998
PMID: 9480869
Human cathepsin K cleaves native type I and II collagens at the N-terminal end of the triple helix.
Kafienah W, Brömme D, Buttle DJ, Croucher LJ, Hollander AP., Biochem J 331 ( Pt 3)(), 1998
PMID: 9560298
Collagenase 1 and collagenase 3 expression in a guinea pig model of osteoarthritis.
Huebner JL, Otterness IG, Freund EM, Caterson B, Kraus VB., Arthritis Rheum 41(5), 1998
PMID: 9588741
Collagenase-3 (MMP-13) expression in chondrosarcoma cells and its regulation by basic fibroblast growth factor.
Uría JA, Balbín M, López JM, Alvarez J, Vizoso F, Takigawa M, López-Otín C., Am J Pathol 153(1), 1998
PMID: 9665469
Stromelysin 1, neutrophil collagenase, and collagenase 3 do not play major roles in a model of chondrocyte mediated cartilage breakdown.
Kozaci LD, Brown CJ, Adcocks C, Galloway A, Hollander AP, Buttle DJ., Mol Pathol 51(5), 1998
PMID: 10193524
Evidence for altered synthesis of type II collagen in patients with osteoarthritis.
Nelson F, Dahlberg L, Laverty S, Reiner A, Pidoux I, Ionescu M, Fraser GL, Brooks E, Tanzer M, Rosenberg LC, Dieppe P, Robin Poole A., J Clin Invest 102(12), 1998
PMID: 9854047

52 References

Data provided by Europe PubMed Central.

Immunolocalization of type X collagen in normal fetal and adult osteoarthritic cartilage with monoclonal antibodies.
Girkontaite I, Frischholz S, Lammi P, Wagner K, Swoboda B, Aigner T, Von der Mark K., Matrix Biol. 15(4), 1996
PMID: 8892223

Export

0 Marked Publications

Open Data PUB

Web of Science

View record in Web of Science®

Sources

PMID: 9119997
PubMed | Europe PMC

Search this title in

Google Scholar