Plasma levels of granulocyte colony-stimulating factor in patients after allogeneic bone marrow transplantation for chronic myeloid leukemia correlate with engraftment of transplanted marrow

Busch FW, Pilgrim TB, Krämer A, Ehninger G (1997)
Bone Marrow Transplantation 19(7): 653-659.

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Granulocyte colony-stimulating factor (G-CSF) is considered to play a pivotal role in hemopoietic regulation, Its pharmacological application is reported to shorten chemotherapy-induced neutropenia as well as time to engraftment in patients after bone marrow transplantation (BRIT), In order possibly to establish further rationale for G-CSF treatment strategies in patients undergoing BMT, me evaluated G-CSF plasma levels of 89 patients after allogeneic BMT for chronic myeloid leukemia (Chit), EDTA anti-coagulated plasma samples were collected starting on day -1 (before grafting) and thereafter twice weekly for four consecutive weeks, G-CSF levels were estimated by enzyme immunoassay. Patients with late (>30 days) bone marrow engraftment had consistently higher G-CSF levels at day +1 (after grafting) compared to patients with early (less than or equal to 30 days) engraftment, while all patients had low plasma levels on day -1/0. Mean G-CSF plasma levels and time to engraftment were correlated (r = 0.79), In univariate analyses, high G-CSF levels at days +1, +4, +7, +10 and several clinical variables (such as TBI, unrelated donor transplant, state of disease) were predictive of late engraftment, Further analysis by multivariate Cos regression resulted in the following predictive model: high G-CSF plasma levels at day +7 and +10 (after grafting), in combination with a blastic phase of the disease were highly predictive of late engraftment, The significantly higher G-CSF levels in patients with impaired engraftment may reflect early compensating mechanisms of the hemopoietic system, which should be investigated further.
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Busch FW, Pilgrim TB, Krämer A, Ehninger G. Plasma levels of granulocyte colony-stimulating factor in patients after allogeneic bone marrow transplantation for chronic myeloid leukemia correlate with engraftment of transplanted marrow. Bone Marrow Transplantation. 1997;19(7):653-659.
Busch, F. W., Pilgrim, T. B., Krämer, A., & Ehninger, G. (1997). Plasma levels of granulocyte colony-stimulating factor in patients after allogeneic bone marrow transplantation for chronic myeloid leukemia correlate with engraftment of transplanted marrow. Bone Marrow Transplantation, 19(7), 653-659. doi:10.1038/sj.bmt.1700722
Busch, F. W., Pilgrim, T. B., Krämer, A., and Ehninger, G. (1997). Plasma levels of granulocyte colony-stimulating factor in patients after allogeneic bone marrow transplantation for chronic myeloid leukemia correlate with engraftment of transplanted marrow. Bone Marrow Transplantation 19, 653-659.
Busch, F.W., et al., 1997. Plasma levels of granulocyte colony-stimulating factor in patients after allogeneic bone marrow transplantation for chronic myeloid leukemia correlate with engraftment of transplanted marrow. Bone Marrow Transplantation, 19(7), p 653-659.
F.W. Busch, et al., “Plasma levels of granulocyte colony-stimulating factor in patients after allogeneic bone marrow transplantation for chronic myeloid leukemia correlate with engraftment of transplanted marrow”, Bone Marrow Transplantation, vol. 19, 1997, pp. 653-659.
Busch, F.W., Pilgrim, T.B., Krämer, A., Ehninger, G.: Plasma levels of granulocyte colony-stimulating factor in patients after allogeneic bone marrow transplantation for chronic myeloid leukemia correlate with engraftment of transplanted marrow. Bone Marrow Transplantation. 19, 653-659 (1997).
Busch, F. W., Pilgrim, T. B., Krämer, Alexander, and Ehninger, G. “Plasma levels of granulocyte colony-stimulating factor in patients after allogeneic bone marrow transplantation for chronic myeloid leukemia correlate with engraftment of transplanted marrow”. Bone Marrow Transplantation 19.7 (1997): 653-659.
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