Deletion in the Z-line region of the titin gene in a baby hamster kidney cell line, BHK-21-Bi

Jackel M, Witt C, Antonova O, Curdt I, Labeit S, Jockusch H (1997)
FEBS LETTERS 408(1): 21-24.

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Abstract
The gene for titin, a 4MDa myofibrillar protein, was analysed in golden hamster DNAs from different sources, using human cDNA probes and PCR. In the DNA from the BHK-21-Bi subline of baby hamster kidney cells, extended sequences coding for Z-line associated domains mere missing, indicating a deletion that renders titin non-functional. These sequences were present in the original BHK-21 line and in hamster DNAs. Our finding shows that, due to the absence of selective pressure on a gene's function, genomic deterioration can occur in a permanent cell line and can lead to a loss of overlapping DNA stretches in both autosomes. (C) 1997 Federation of European Biochemical Societies.
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Jackel M, Witt C, Antonova O, Curdt I, Labeit S, Jockusch H. Deletion in the Z-line region of the titin gene in a baby hamster kidney cell line, BHK-21-Bi. FEBS LETTERS. 1997;408(1):21-24.
Jackel, M., Witt, C., Antonova, O., Curdt, I., Labeit, S., & Jockusch, H. (1997). Deletion in the Z-line region of the titin gene in a baby hamster kidney cell line, BHK-21-Bi. FEBS LETTERS, 408(1), 21-24.
Jackel, M., Witt, C., Antonova, O., Curdt, I., Labeit, S., and Jockusch, H. (1997). Deletion in the Z-line region of the titin gene in a baby hamster kidney cell line, BHK-21-Bi. FEBS LETTERS 408, 21-24.
Jackel, M., et al., 1997. Deletion in the Z-line region of the titin gene in a baby hamster kidney cell line, BHK-21-Bi. FEBS LETTERS, 408(1), p 21-24.
M. Jackel, et al., “Deletion in the Z-line region of the titin gene in a baby hamster kidney cell line, BHK-21-Bi”, FEBS LETTERS, vol. 408, 1997, pp. 21-24.
Jackel, M., Witt, C., Antonova, O., Curdt, I., Labeit, S., Jockusch, H.: Deletion in the Z-line region of the titin gene in a baby hamster kidney cell line, BHK-21-Bi. FEBS LETTERS. 408, 21-24 (1997).
Jackel, M, Witt, C, Antonova, O, Curdt, I, Labeit, S, and Jockusch, Harald. “Deletion in the Z-line region of the titin gene in a baby hamster kidney cell line, BHK-21-Bi”. FEBS LETTERS 408.1 (1997): 21-24.
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