On-Resin Click-Glycoconjugation of Peptoids

Norgren AS, Budke C, Majer Z, Heggemann C, Koop T, Sewald N (2009)
SYNTHESIS-STUTTGART 2009(03): 488-494.

Journal Article | Published | English

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Abstract
Peptoids are unnatural peptide-like oligomers having the side-chain attached to the glycine nitrogen. In order to investigate how such oligomers are affected upon glycoconjugation, a series of glycosylated peptoids has been synthesized. The conjugation between glycosyl residue and peptoid was achieved by azide + alkyne [3+2] cycloaddition (click reaction). The glycosylated peptoids were obtained by either stepwise assembly from sarcosine and glycosylated monomers or global on-resin click glycoconjugation. CD spectroscopic studies were performed on both unglycosylated and glycosylated peptoids with varying chain-length, revealing length and substituent dependences. Additionally, three peptoids were tested for antifreeze activity.
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Norgren AS, Budke C, Majer Z, Heggemann C, Koop T, Sewald N. On-Resin Click-Glycoconjugation of Peptoids. SYNTHESIS-STUTTGART. 2009;2009(03):488-494.
Norgren, A. S., Budke, C., Majer, Z., Heggemann, C., Koop, T., & Sewald, N. (2009). On-Resin Click-Glycoconjugation of Peptoids. SYNTHESIS-STUTTGART, 2009(03), 488-494.
Norgren, A. S., Budke, C., Majer, Z., Heggemann, C., Koop, T., and Sewald, N. (2009). On-Resin Click-Glycoconjugation of Peptoids. SYNTHESIS-STUTTGART 2009, 488-494.
Norgren, A.S., et al., 2009. On-Resin Click-Glycoconjugation of Peptoids. SYNTHESIS-STUTTGART, 2009(03), p 488-494.
A.S. Norgren, et al., “On-Resin Click-Glycoconjugation of Peptoids”, SYNTHESIS-STUTTGART, vol. 2009, 2009, pp. 488-494.
Norgren, A.S., Budke, C., Majer, Z., Heggemann, C., Koop, T., Sewald, N.: On-Resin Click-Glycoconjugation of Peptoids. SYNTHESIS-STUTTGART. 2009, 488-494 (2009).
Norgren, Anna S., Budke, Carsten, Majer, Zsuzsa, Heggemann, Carolin, Koop, Thomas, and Sewald, Norbert. “On-Resin Click-Glycoconjugation of Peptoids”. SYNTHESIS-STUTTGART 2009.03 (2009): 488-494.
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