One-year functional magnetic resonance imaging follow-up study of neural activation during the recall of unresolved negative life events in borderline personality disorder

Driessen M, Wingenfeld K, Rullkoetter N, Mensebach C, Woermann FG, Mertens M, Beblo T (2009)
PSYCHOLOGICAL MEDICINE 39(03): 507-516.

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Zeitschriftenaufsatz | Veröffentlicht | Englisch
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Abstract / Bemerkung
Background. Recall of adverse life events under brain imaging conditions has been shown to coincide with activation of limbic and prefrontal brain areas in borderline personality disorder (BPD). We investigate changes of functional magnetic resonance imaging (fMRI) activation patterns during the recall Of unresolved adverse life events (ULE) over 1 year. Method. Thirteen female BPD patients participated in the study During fMRI measurement subjects recalled ULF and negative but resolved life events (RLE) after individual cue words to Stimulate autobiographical memory, retrieval. Subjective intensity of emotional and sensoric experiences during recall was assessed as well as standardized measures of psychopathology. Results. A 2 x 2 factorial analysis of fMRI data (Delta t1/t2 x Delta ULE/RLE) revealed major right more than left differences of activation (i.e. t1 > t2) of the posterior more than anterior cingulate, superior temporal lobes, insula, and right middle and superior frontal lobes (second-level analysis, t = 3.0, p(uncorrected) = 0.003). The opposite contrast (Delta t2/t1 x Delta ULE/RLE) did not reveal an), differences. We did not find changes of emotional or sensoric qualities during recall (ULF versus RLE) or of psychopathology measures over the 1-year period. Conclusions. Although subjective and clinical data did not change within 1 year, we observed a substantial decrease of temporo-frontal activation during the recall of ULF from t1 to t2 If future research confirms these findings, the question arises whether the decrease of neural activation precedes clinical improvement in BPD.
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Zeitschriftentitel
PSYCHOLOGICAL MEDICINE
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39
Zeitschriftennummer
03
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507-516
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Driessen M, Wingenfeld K, Rullkoetter N, et al. One-year functional magnetic resonance imaging follow-up study of neural activation during the recall of unresolved negative life events in borderline personality disorder. PSYCHOLOGICAL MEDICINE. 2009;39(03):507-516.
Driessen, M., Wingenfeld, K., Rullkoetter, N., Mensebach, C., Woermann, F. G., Mertens, M., & Beblo, T. (2009). One-year functional magnetic resonance imaging follow-up study of neural activation during the recall of unresolved negative life events in borderline personality disorder. PSYCHOLOGICAL MEDICINE, 39(03), 507-516. doi:10.1017/S0033291708003358
Driessen, M., Wingenfeld, K., Rullkoetter, N., Mensebach, C., Woermann, F. G., Mertens, M., and Beblo, T. (2009). One-year functional magnetic resonance imaging follow-up study of neural activation during the recall of unresolved negative life events in borderline personality disorder. PSYCHOLOGICAL MEDICINE 39, 507-516.
Driessen, M., et al., 2009. One-year functional magnetic resonance imaging follow-up study of neural activation during the recall of unresolved negative life events in borderline personality disorder. PSYCHOLOGICAL MEDICINE, 39(03), p 507-516.
M. Driessen, et al., “One-year functional magnetic resonance imaging follow-up study of neural activation during the recall of unresolved negative life events in borderline personality disorder”, PSYCHOLOGICAL MEDICINE, vol. 39, 2009, pp. 507-516.
Driessen, M., Wingenfeld, K., Rullkoetter, N., Mensebach, C., Woermann, F.G., Mertens, M., Beblo, T.: One-year functional magnetic resonance imaging follow-up study of neural activation during the recall of unresolved negative life events in borderline personality disorder. PSYCHOLOGICAL MEDICINE. 39, 507-516 (2009).
Driessen, Martin, Wingenfeld, K., Rullkoetter, N., Mensebach, C., Woermann, F. G., Mertens, M., and Beblo, Thomas. “One-year functional magnetic resonance imaging follow-up study of neural activation during the recall of unresolved negative life events in borderline personality disorder”. PSYCHOLOGICAL MEDICINE 39.03 (2009): 507-516.

7 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Neural Response during the Activation of the Attachment System in Patients with Borderline Personality Disorder: An fMRI Study.
Buchheim A, Erk S, George C, Kächele H, Martius P, Pokorny D, Spitzer M, Walter H., Front Hum Neurosci 10(), 2016
PMID: 27531977
Autobiographical memory in borderline personality disorder-A systematic review.
Bech M, Elklit A, Simonsen E., Personal Ment Health 9(2), 2015
PMID: 25940516
Shifted intrinsic connectivity of central executive and salience network in borderline personality disorder.
Doll A, Sorg C, Manoliu A, Wöller A, Meng C, Förstl H, Zimmer C, Wohlschläger AM, Riedl V., Front Hum Neurosci 7(), 2013
PMID: 24198777
Functional connectivity of pain-mediated affect regulation in Borderline Personality Disorder.
Niedtfeld I, Kirsch P, Schulze L, Herpertz SC, Bohus M, Schmahl C., PLoS One 7(3), 2012
PMID: 22428013
Neuronal correlates of cognitive reappraisal in borderline patients with affective instability.
Schulze L, Domes G, Krüger A, Berger C, Fleischer M, Prehn K, Schmahl C, Grossmann A, Hauenstein K, Herpertz SC., Biol Psychiatry 69(6), 2011
PMID: 21195392
Borderline personality disorder: hypothalamus pituitary adrenal axis and findings from neuroimaging studies.
Wingenfeld K, Spitzer C, Rullkötter N, Löwe B., Psychoneuroendocrinology 35(1), 2010
PMID: 19837517

42 References

Daten bereitgestellt von Europe PubMed Central.

Positron-emission tomography and personality disorders.
Goyer PF, Andreason PJ, Semple WE, Clayton AH, King AC, Compton-Toth BA, Schulz SC, Cohen RM., Neuropsychopharmacology 10(1), 1994
PMID: 8179791
Brain and conscious experience.
Gazzaniga MS., Adv Neurol 77(), 1998
PMID: 9709824

freyberger, 1999

franke, 1995

first, 1996

wittchen, 1997
Neural correlates of memories of childhood sexual abuse in women with and without posttraumatic stress disorder.
Bremner JD, Narayan M, Staib LH, Southwick SM, McGlashan T, Charney DS., Am J Psychiatry 156(11), 1999
PMID: 10553744
Subtle prefrontal neuropathology in a pilot magnetic resonance spectroscopy study in patients with borderline personality disorder.
van Elst LT, Thiel T, Hesslinger B, Lieb K, Bohus M, Hennig J, Ebert D., J Neuropsychiatry Clin Neurosci 13(4), 2001
PMID: 11748321
An inventory for measuring depression.
BECK AT, WARD CH, MENDELSON M, MOCK J, ERBAUGH J., Arch. Gen. Psychiatry 4(), 1961
PMID: 13688369

beck, 1994

rey, 1964

maercker, diagnostica 3(), 1998
Evidence of abnormal amygdala functioning in borderline personality disorder: a functional MRI study.
Herpertz SC, Dietrich TM, Wenning B, Krings T, Erberich SG, Willmes K, Thron A, Sass H., Biol. Psychiatry 50(4), 2001
PMID: 11522264
Brain glucose metabolism in borderline personality disorder.
De La Fuente JM, Goldman S, Stanus E, Vizuete C, Morlan I, Bobes J, Mendlewicz J., J Psychiatr Res 31(5), 1997
PMID: 9368195
A fenfluramine-activated FDG-PET study of borderline personality disorder.
Soloff PH, Meltzer CC, Greer PJ, Constantine D, Kelly TM., Biol. Psychiatry 47(6), 2000
PMID: 10715360
Cognitive and emotional influences in anterior cingulate cortex.
Bush G, Luu P, Posner MI., Trends Cogn. Sci. (Regul. Ed.) 4(6), 2000
PMID: 10827444
Imaging neuroscience: principles or maps?
Friston KJ., Proc. Natl. Acad. Sci. U.S.A. 95(3), 1998
PMID: 9448243
Brain Regional alpha-[11C]methyl-L-tryptophan trapping in impulsive subjects with borderline personality disorder.
Leyton M, Okazawa H, Diksic M, Paris J, Rosa P, Mzengeza S, Young SN, Blier P, Benkelfat C., Am J Psychiatry 158(5), 2001
PMID: 11329401
Brain structures in pediatric maltreatment-related posttraumatic stress disorder: a sociodemographically matched study.
De Bellis MD, Keshavan MS, Shifflett H, Iyengar S, Beers SR, Hall J, Moritz G., Biol. Psychiatry 52(11), 2002
PMID: 12460690
Positron emission tomography in female patients with borderline personality disorder.
Juengling FD, Schmahl C, Hesslinger B, Ebert D, Bremner JD, Gostomzyk J, Bohus M, Lieb K., J Psychiatr Res 37(2), 2003
PMID: 12842164
Impulsivity and prefrontal hypometabolism in borderline personality disorder.
Soloff PH, Meltzer CC, Becker C, Greer PJ, Kelly TM, Constantine D., Psychiatry Res 123(3), 2003
PMID: 12928103
The relationship of borderline personality disorder to posttraumatic stress disorder and traumatic events.
Golier JA, Yehuda R, Bierer LM, Mitropoulou V, New AS, Schmeidler J, Silverman JM, Siever LJ., Am J Psychiatry 160(11), 2003
PMID: 14594750
Posttraumatic stress disorder and fMRI activation patterns of traumatic memory in patients with borderline personality disorder.
Driessen M, Beblo T, Mertens M, Piefke M, Rullkoetter N, Silva-Saavedra A, Reddemann L, Rau H, Markowitsch HJ, Wulff H, Lange W, Woermann FG., Biol. Psychiatry 55(6), 2004
PMID: 15013829
A positron emission tomography study of memories of childhood abuse in borderline personality disorder.
Schmahl CG, Vermetten E, Elzinga BM, Bremner JD., Biol. Psychiatry 55(7), 2004
PMID: 15039006
The human cortex responds to an interoceptive challenge.
Critchley HD., Proc. Natl. Acad. Sci. U.S.A. 101(17), 2004
PMID: 15096592
Stressful life events as predictors of functioning: findings from the collaborative longitudinal personality disorders study.
Pagano ME, Skodol AE, Stout RL, Shea MT, Yen S, Grilo CM, Sanislow CA, Bender DS, McGlashan TH, Zanarini MC, Gunderson JG., Acta Psychiatr Scand 110(6), 2004
PMID: 15521826
A functional magnetic resonance imaging study of amygdala and medial prefrontal cortex responses to overtly presented fearful faces in posttraumatic stress disorder.
Shin LM, Wright CI, Cannistraro PA, Wedig MM, McMullin K, Martis B, Macklin ML, Lasko NB, Cavanagh SR, Krangel TS, Orr SP, Pitman RK, Whalen PJ, Rauch SL., Arch. Gen. Psychiatry 62(3), 2005
PMID: 15753240
Neural basis of fear conditioning induced by video clip: positron emission tomography study.
Doronbekov TK, Tokunaga H, Ikejiri Y, Kazui H, Hatta N, Masaki Y, Ogino A, Miyoshi N, Oku N, Nishikawa T, Takeda M., Psychiatry Clin. Neurosci. 59(2), 2005
PMID: 15823161
[Neuroimaging findings in posttraumatic stress disorder: review of the literature]
Jatzko A, Schmitt A, Kordon A, Braus DF., Fortschr Neurol Psychiatr 73(7), 2005
PMID: 16012917
Cytology and functionally correlated circuits of human posterior cingulate areas.
Vogt BA, Vogt L, Laureys S., Neuroimage 29(2), 2005
PMID: 16140550
A review of neuroimaging studies in PTSD: heterogeneity of response to symptom provocation.
Lanius RA, Bluhm R, Lanius U, Pain C., J Psychiatr Res 40(8), 2005
PMID: 16214172
Neurobiological substrates of antisocial and borderline personality disorder: preliminary results of a functional fMRI study.
Vollm B, Richardson P, Stirling J, Elliott R, Dolan M, Chaudhry I, Del Ben C, McKie S, Anderson I, Deakin B., Crim Behav Ment Health 14(1), 2004
PMID: 14654860
Functional MRI correlates of the recall of unresolved life events in borderline personality disorder.
Beblo T, Driessen M, Mertens M, Wingenfeld K, Piefke M, Rullkoetter N, Silva-Saavedra A, Mensebach C, Reddemann L, Rau H, Markowitsch HJ, Wulff H, Lange W, Berea C, Ollech I, Woermann FG., Psychol Med 36(6), 2006
PMID: 16704749
Prediction of the 10-year course of borderline personality disorder.
Zanarini MC, Frankenburg FR, Hennen J, Reich DB, Silk KR., Am J Psychiatry 163(5), 2006
PMID: 16648323
Descriptive and longitudinal observations on the relationship of borderline personality disorder and bipolar disorder.
Gunderson JG, Weinberg I, Daversa MT, Kueppenbender KD, Zanarini MC, Shea MT, Skodol AE, Sanislow CA, Yen S, Morey LC, Grilo CM, McGlashan TH, Stout RL, Dyck I., Am J Psychiatry 163(7), 2006
PMID: 16816221
Amygdala, medial prefrontal cortex, and hippocampal function in PTSD.
Shin LM, Rauch SL, Pitman RK., Ann. N. Y. Acad. Sci. 1071(), 2006
PMID: 16891563
Development, reliability, and validity of a dissociation scale.
Bernstein EM, Putnam FW., J. Nerv. Ment. Dis. 174(12), 1986
PMID: 3783140
Deficits in visual functions and neuropsychological inconsistency in Borderline Personality Disorder.
Beblo T, Saavedra AS, Mensebach C, Lange W, Markowitsch HJ, Rau H, Woermann FG, Driessen M., Psychiatry Res 145(2-3), 2006
PMID: 17070927

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