Diesel motor emissions and lung cancer mortality-Results of the second follow-up of a cohort study in potash miners

Neumeyer-Gromen A, Razum O, Kersten N, Seidler A, Zeeb H (2009)
INTERNATIONAL JOURNAL OF CANCER 124(8): 1900-1906.

Journal Article | Published | English

No fulltext has been uploaded

Author
; ; ; ;
Abstract
International health authorities have graded diesel motor emissions (DME) as probably cancerogenic in human beings. There are gaps in epidemiological evidence regarding exact exposure quantification, confounder control and the investigation of highly exposed populations. We investigated the association of DME ana lung cancer mortality in a historical cohort study of 5,862 German potash miners who were followed from 1970 to 2001. Cumulative exposure (CE) was measured by representative concentrations of total carbon multiplied with exposure years from the mines' medical records. Exposure and smoking behavior were validated by interviews of 3,087 participants. We computed standardized mortality ratios (SMR, external comparison) and performed Cox regression (internal comparison). The relative risk estimates (RR) with 95%-confidence intervals were adjusted for age and smoking. Vital status and causes of death were confirmed for 98.1% of participants. Sixty-one lung cancer deaths occurred. SMR-analysis showed lower than expected lung cancer mortality (healthy-worker-effect). Internal comparisons revealed risk elevations from moderate to risk doubling depending oil the exposure categories used (dichotomized: up to RR 1.43[0.67-3.03] for a CE of 4.90[mg/m(3)]*years as compared with less exposure; quintiles: RR 1.13[0.46-2.75], 2.47[1.02-6.02], 1.50[0.56-4.04] and 2.28[0.87-5.97] for a CE up to 2.04, 2.73, 3.90 and >3.90, respectively, as compared with the reference of <1.29[mg/m(3)] *years). Additional adjustment of length of follow-up leads to further RR increases and indicates healthy-worker-survivor-phenomena. The analyses of a sub-cohort (n = 3,335) with particularly accurate exposure measurement revealed a nonsignificant dose-response-relationship. Our results support an association of DME and lung cancer mortality. (C) 2008 Wiley-Liss, Inc.
Publishing Year
ISSN
eISSN
PUB-ID

Cite this

Neumeyer-Gromen A, Razum O, Kersten N, Seidler A, Zeeb H. Diesel motor emissions and lung cancer mortality-Results of the second follow-up of a cohort study in potash miners. INTERNATIONAL JOURNAL OF CANCER. 2009;124(8):1900-1906.
Neumeyer-Gromen, A., Razum, O., Kersten, N., Seidler, A., & Zeeb, H. (2009). Diesel motor emissions and lung cancer mortality-Results of the second follow-up of a cohort study in potash miners. INTERNATIONAL JOURNAL OF CANCER, 124(8), 1900-1906.
Neumeyer-Gromen, A., Razum, O., Kersten, N., Seidler, A., and Zeeb, H. (2009). Diesel motor emissions and lung cancer mortality-Results of the second follow-up of a cohort study in potash miners. INTERNATIONAL JOURNAL OF CANCER 124, 1900-1906.
Neumeyer-Gromen, A., et al., 2009. Diesel motor emissions and lung cancer mortality-Results of the second follow-up of a cohort study in potash miners. INTERNATIONAL JOURNAL OF CANCER, 124(8), p 1900-1906.
A. Neumeyer-Gromen, et al., “Diesel motor emissions and lung cancer mortality-Results of the second follow-up of a cohort study in potash miners”, INTERNATIONAL JOURNAL OF CANCER, vol. 124, 2009, pp. 1900-1906.
Neumeyer-Gromen, A., Razum, O., Kersten, N., Seidler, A., Zeeb, H.: Diesel motor emissions and lung cancer mortality-Results of the second follow-up of a cohort study in potash miners. INTERNATIONAL JOURNAL OF CANCER. 124, 1900-1906 (2009).
Neumeyer-Gromen, Angela, Razum, Oliver, Kersten, Norbert, Seidler, Andreas, and Zeeb, Hajo. “Diesel motor emissions and lung cancer mortality-Results of the second follow-up of a cohort study in potash miners”. INTERNATIONAL JOURNAL OF CANCER 124.8 (2009): 1900-1906.
This data publication is cited in the following publications:
This publication cites the following data publications:

14 Citations in Europe PMC

Data provided by Europe PubMed Central.

Diesel exhaust exposure and the risk of lung cancer--a review of the epidemiological evidence.
Sun Y, Bochmann F, Nold A, Mattenklott M., Int J Environ Res Public Health 11(2), 2014
PMID: 24473109
Exposure-response estimates for diesel engine exhaust and lung cancer mortality based on data from three occupational cohorts.
Vermeulen R, Silverman DT, Garshick E, Vlaanderen J, Portengen L, Steenland K., Environ. Health Perspect. 122(2), 2014
PMID: 24273233
Diesel motor exhaust and lung cancer mortality: reanalysis of a cohort study in potash miners.
Mohner M, Kersten N, Gellissen J., Eur. J. Epidemiol. 28(2), 2013
PMID: 23420499
Lung cancer and elemental carbon exposure in trucking industry workers.
Garshick E, Laden F, Hart JE, Davis ME, Eisen EA, Smith TJ., Environ. Health Perspect. 120(9), 2012
PMID: 22739103
Diesel exhaust in miners study: how to understand the findings?
Morfeld P., J Occup Med Toxicol 7(1), 2012
PMID: 22676299
Health effects research and regulation of diesel exhaust: an historical overview focused on lung cancer risk.
Hesterberg TW, Long CM, Bunn WB, Lapin CA, McClellan RO, Valberg PA., Inhal Toxicol 24 Suppl 1(), 2012
PMID: 22663144
Lung cancer and diesel exhaust: an updated critical review of the occupational epidemiology literature.
Gamble JF, Nicolich MJ, Boffetta P., Crit. Rev. Toxicol. 42(7), 2012
PMID: 22656672
The Diesel Exhaust in Miners study: a nested case-control study of lung cancer and diesel exhaust.
Silverman DT, Samanic CM, Lubin JH, Blair AE, Stewart PA, Vermeulen R, Coble JB, Rothman N, Schleiff PL, Travis WD, Ziegler RG, Wacholder S, Attfield MD., J. Natl. Cancer Inst. 104(11), 2012
PMID: 22393209
The Diesel Exhaust in Miners study: a cohort mortality study with emphasis on lung cancer.
Attfield MD, Schleiff PL, Lubin JH, Blair A, Stewart PA, Vermeulen R, Coble JB, Silverman DT., J. Natl. Cancer Inst. 104(11), 2012
PMID: 22393207
Biology of diesel exhaust effects on allergic pulmonary inflammation.
Inoue K, Takano H., Yakugaku Zasshi 131(3), 2011
PMID: 21372531
Research recommendations for selected IARC-classified agents.
Ward EM, Schulte PA, Straif K, Hopf NB, Caldwell JC, Carreon T, DeMarini DM, Fowler BA, Goldstein BD, Hemminki K, Hines CJ, Pursiainen KH, Kuempel E, Lewtas J, Lunn RM, Lynge E, McElvenny DM, Muhle H, Nakajima T, Robertson LW, Rothman N, Ruder AM, Schubauer-Berigan MK, Siemiatycki J, Silverman D, Smith MT, Sorahan T, Steenland K, Stevens RG, Vineis P, Zahm SH, Zeise L, Cogliano VJ., Environ. Health Perspect. 118(10), 2010
PMID: 20562050

46 References

Data provided by Europe PubMed Central.

Lung and bladder cancer among Danish urban bus drivers and tramway employees: a nested case-control study.
Soll-Johanning H, Bach E, Jensen SS., Occup Med (Lond) 53(1), 2003
PMID: 12576562
Smoking and occupation from the European Community Respiratory Health Survey.
McCurdy SA, Sunyer J, Zock JP, Anto JM, Kogevinas M; European Community Respiratory Health Survey Study Group., Occup Environ Med 60(9), 2003
PMID: 12937184
Inhaled particles and lung cancer. Part A: Mechanisms.
Knaapen AM, Borm PJ, Albrecht C, Schins RP., Int. J. Cancer 109(6), 2004
PMID: 15027112
Occupational exposure to diesel and gasoline engine exhausts and risk of lung cancer among Finnish workers.
Guo J, Kauppinen T, Kyyronen P, Lindbohm ML, Heikkila P, Pukkala E., Am. J. Ind. Med. 45(6), 2004
PMID: 15164392
Lung cancer risk in male workers occupationally exposed to diesel motor emissions in Germany.
Bruske-Hohlfeld I, Mohner M, Ahrens W, Pohlabeln H, Heinrich J, Kreuzer M, Jockel KH, Wichmann HE., Am. J. Ind. Med. 36(4), 1999
PMID: 10470005
Diesel exhaust and lung cancer mortality in potash mining.
Saverin R, Braunlich A, Dahmann D, Enderlein G, Heuchert G., Am. J. Ind. Med. 36(4), 1999
PMID: 10470006
Occupational risk factors for kidney cancer: a cohort study in Sweden.
Ji J, Granstrom C, Hemminki K., World J Urol 23(4), 2005
PMID: 16133557
Smoking imputation and lung cancer in railroad workers exposed to diesel exhaust.
Garshick E, Laden F, Hart JE, Smith TJ, Rosner B., Am. J. Ind. Med. 49(9), 2006
PMID: 16767725
Historical estimation of diesel exhaust exposure in a cohort study of U.S. railroad workers and lung cancer.
Laden F, Hart JE, Eschenroeder A, Smith TJ, Garshick E., Cancer Causes Control 17(7), 2006
PMID: 16841258
Occupational exposure to diesel exhausts and risk for lung cancer in a population-based case-control study in Italy.
Richiardi L, Mirabelli D, Calisti R, Ottino A, Ferrando A, Boffetta P, Merletti F., Ann. Oncol. 17(12), 2006
PMID: 16971668
Bias in occupational epidemiology studies.
Pearce N, Checkoway H, Kriebel D., Occup Environ Med 64(8), 2007
PMID: 17053019
Diesel Exhaust Exposure and Smoking
Emmelin, Epidemiology 4(3), 1993
Confounding by Time since Hire in Internal Comparisons of Cumulative Exposure in Occupational Cohort Studies
Flanders, Epidemiology 4(4), 1993
Conditions for bias from differential left truncation.
Howards PP, Hertz-Picciotto I, Poole C., Am. J. Epidemiol. 165(4), 2007
PMID: 17150983
The 15-Country Collaborative Study of Cancer Risk among Radiation Workers in the Nuclear Industry: estimates of radiation-related cancer risks.
Cardis E, Vrijheid M, Blettner M, Gilbert E, Hakama M, Hill C, Howe G, Kaldor J, Muirhead CR, Schubauer-Berigan M, Yoshimura T, Bermann F, Cowper G, Fix J, Hacker C, Heinmiller B, Marshall M, Thierry-Chef I, Utterback D, Ahn YO, Amoros E, Ashmore P, Auvinen A, Bae JM, Bernar J, Biau A, Combalot E, Deboodt P, Diez Sacristan A, Eklof M, Engels H, Engholm G, Gulis G, Habib RR, Holan K, Hyvonen H, Kerekes A, Kurtinaitis J, Malker H, Martuzzi M, Mastauskas A, Monnet A, Moser M, Pearce MS, Richardson DB, Rodriguez-Artalejo F, Rogel A, Tardy H, Telle-Lamberton M, Turai I, Usel M, Veress K., Radiat. Res. 167(4), 2007
PMID: 17388693
Diesel exhaust exposure and mortality among males in the American Cancer Society prospective study.
Boffetta P, Stellman SD, Garfinkel L., Am. J. Ind. Med. 14(4), 1988
PMID: 3189356
A follow-up study on the mortality of truck drivers.
Hansen ES., Am. J. Ind. Med. 23(5), 1993
PMID: 7685146
Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies.
von Elm E, Altman DG, Egger M, Pocock SJ, Gotzsche PC, Vandenbroucke JP; STROBE Initiative., BMJ 335(7624), 2007
PMID: 17947786
Diesel Exhaust
Frumkin, CA A Cancer Journal for Clinicians 51(3), 2001

Export

0 Marked Publications

Open Data PUB

Web of Science

View record in Web of Science®

Sources

PMID: 19123464
PubMed | Europe PMC

Search this title in

Google Scholar