Neural correlates of the individual emotional Stroop in borderline personality disorder

Wingenfeld K, Rullkoetter N, Mensebach C, Beblo T, Mertens M, Kreisel S, Toepper M, Driessen M, Woermann FG (2009)
PSYCHONEUROENDOCRINOLOGY 34(4): 571-586.

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Abstract
Objective: Emotional dysregulation is a key feature of borderline personality disorder (BPD) with altered inhibitory functions having suggested as being crucial. The anterior cingulate cortex and further prefrontal brain regions are crucial for response inhibition. The regulation of emotions is ensured via inhibitory control over the amygdala. The present study aimed to investigate neural correlates of response inhibition in BPD by using an emotional Stroop paradigm extending the task to word stimuli which were related to stressful life events. Methods: Twenty BPD patients and 20 healthy controls underwent functional magnetic resonance imaging (fMRI) while performing the individual emotional Stroop task. A block design was used with the following word type conditions: neutral words, general negative words, and individual negative words. The individual negative words were recruited from a prior interview conducted with each participant. Results: While BPD patients had overall slower reaction times in the Stroop task compared to healthy controls, there was no increased slowing with emotional interference. Controls exhibited significant fMRI blood oxygenation level-dependent signal increases in the anterior cingulate cortex as welt as in frontal cortex contrasting generally negative vs. neutral and individual negative vs. neutral conditions, respectively. BPD patients did not show equivalent signal changes. Conclusions: These results provide further evidence for a dysfunctional network of brain areas in BPD, including the ACC and frontal brain regions. These areas are crucial for the regulation of stress and emotions, the core problems of BPD patients. (C) 2008 Elsevier Ltd. All rights reserved.
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Wingenfeld K, Rullkoetter N, Mensebach C, et al. Neural correlates of the individual emotional Stroop in borderline personality disorder. PSYCHONEUROENDOCRINOLOGY. 2009;34(4):571-586.
Wingenfeld, K., Rullkoetter, N., Mensebach, C., Beblo, T., Mertens, M., Kreisel, S., Toepper, M., et al. (2009). Neural correlates of the individual emotional Stroop in borderline personality disorder. PSYCHONEUROENDOCRINOLOGY, 34(4), 571-586.
Wingenfeld, K., Rullkoetter, N., Mensebach, C., Beblo, T., Mertens, M., Kreisel, S., Toepper, M., Driessen, M., and Woermann, F. G. (2009). Neural correlates of the individual emotional Stroop in borderline personality disorder. PSYCHONEUROENDOCRINOLOGY 34, 571-586.
Wingenfeld, K., et al., 2009. Neural correlates of the individual emotional Stroop in borderline personality disorder. PSYCHONEUROENDOCRINOLOGY, 34(4), p 571-586.
K. Wingenfeld, et al., “Neural correlates of the individual emotional Stroop in borderline personality disorder”, PSYCHONEUROENDOCRINOLOGY, vol. 34, 2009, pp. 571-586.
Wingenfeld, K., Rullkoetter, N., Mensebach, C., Beblo, T., Mertens, M., Kreisel, S., Toepper, M., Driessen, M., Woermann, F.G.: Neural correlates of the individual emotional Stroop in borderline personality disorder. PSYCHONEUROENDOCRINOLOGY. 34, 571-586 (2009).
Wingenfeld, Katja, Rullkoetter, Nina, Mensebach, Christoph, Beblo, Thomas, Mertens, Markus, Kreisel, Stefan, Toepper, Max, Driessen, Martin, and Woermann, Friedrich G. “Neural correlates of the individual emotional Stroop in borderline personality disorder”. PSYCHONEUROENDOCRINOLOGY 34.4 (2009): 571-586.
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98 References

Data provided by Europe PubMed Central.

Amygdala, medial prefrontal cortex, and hippocampal function in PTSD
Shin, Ann. N.Y. Acad. Sci. 1071(), 2006
An fMRI study of anterior cingulate function in posttraumatic stress disorder.
Shin LM, Whalen PJ, Pitman RK, Bush G, Macklin ML, Lasko NB, Orr SP, McInerney SC, Rauch SL., Biol. Psychiatry 50(12), 2001
PMID: 11750889
A functional magnetic resonance imaging study of amygdala and medial prefrontal cortex responses to overtly presented fearful faces in posttraumatic stress disorder.
Shin LM, Wright CI, Cannistraro PA, Wedig MM, McMullin K, Martis B, Macklin ML, Lasko NB, Cavanagh SR, Krangel TS, Orr SP, Pitman RK, Whalen PJ, Rauch SL., Arch. Gen. Psychiatry 62(3), 2005
PMID: 15753240
Successful psychotherapy reduces hypervigilance in borderline personality disorder
Sieswerda, Behav. Cognit. Psychother. 35(), 2007
Hypervigilance in patients with borderline personality disorder: specificity, automaticity, and predictors.
Sieswerda S, Arntz A, Mertens I, Vertommen S., Behav Res Ther 45(5), 2007
PMID: 17045566
Basal norepinephrine in depersonalization disorder.
Simeon D, Guralnik O, Knutelska M, Yehuda R, Schmeidler J., Psychiatry Res 121(1), 2003
PMID: 14572626
Impulsivity and prefrontal hypometabolism in borderline personality disorder.
Soloff PH, Meltzer CC, Becker C, Greer PJ, Kelly TM, Constantine D., Psychiatry Res 123(3), 2003
PMID: 12928103
A fenfluramine-activated FDG-PET study of borderline personality disorder.
Soloff PH, Meltzer CC, Greer PJ, Constantine D, Kelly TM., Biol. Psychiatry 47(6), 2000
PMID: 10715360
Neuropsychological functioning in patients with borderline personality disorder.
Sprock J, Rader TJ, Kendall JP, Yoder CY., J Clin Psychol 56(12), 2000
PMID: 11132573
Entwicklung und psychometrische Charakteristika der Dissoziations-Spannungs-Skala akut (DSS-akut)
Stiglmayr, Psychother. Psych. Med. 53(), 2003
Isolation of specific interference processing in the Stroop task: PET activation studies.
Taylor SF, Kornblum S, Lauber EJ, Minoshima S, Koeppe RA., Neuroimage 6(2), 1997
PMID: 9299382
Frontolimbic brain abnormalities in patients with borderline personality disorder: a volumetric magnetic resonance imaging study.
Tebartz van Elst L, Hesslinger B, Thiel T, Geiger E, Haegele K, Lemieux L, Lieb K, Bohus M, Hennig J, Ebert D., Biol. Psychiatry 54(2), 2003
PMID: 12873806
Enhanced rostral anterior cingulate cortex activation during cognitive control is related to orbitofrontal volume reduction in unipolar depression.
Wagner G, Koch K, Schachtzabel C, Reichenbach JR, Sauer H, Schlosser Md RG., J Psychiatry Neurosci 33(3), 2008
PMID: 18592043
The emotional counting Stroop paradigm: a functional magnetic resonance imaging probe of the anterior cingulate affective division.
Whalen PJ, Bush G, McNally RJ, Wilhelm S, McInerney SC, Jenike MA, Rauch SL., Biol. Psychiatry 44(12), 1998
PMID: 9861465
The emotional Stroop task and psychopathology.
Williams JM, Mathews A, MacLeod C., Psychol Bull 120(1), 1996
PMID: 8711015
Attention bias towards personally relevant stimuli: the individual emotional Stroop task.
Wingenfeld K, Bullig R, Mensebach C, Hartje W, Driessen M, Beblo T., Psychol Rep 99(3), 2006
PMID: 17305196
Dexamethasone suppression test in borderline personality disorder: impact of PTSD symptoms.
Wingenfeld K, Hill A, Adam B, Driessen M., Psychiatry Clin. Neurosci. 61(6), 2007
PMID: 18081632

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Prediction of the 10-year course of borderline personality disorder.
Zanarini MC, Frankenburg FR, Hennen J, Reich DB, Silk KR., Am J Psychiatry 163(5), 2006
PMID: 16648323

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