Membrane-Protein Interactions in a Generic Coarse-Grained Model for Lipid Bilayers

West B, Brown FLH, Schmid F (2009)
Biophysical Journal 96(1): 101-115.

Download
No fulltext has been uploaded. References only!
Journal Article | Original Article | Published | English

No fulltext has been uploaded

Author
; ;
Abstract
We study membrane-protein interactions and membrane-mediated protein-protein interactions by Monte Carlo simulations of a generic coarse-grained model for lipid bilayers with cylindrical hydrophobic inclusions. The strength of the hydrophobic force and the hydrophobic thickness of the proteins are systematically varied. The results are compared with analytical predictions of two popular analytical theories: The Landau-de Gennes theory and the elastic theory. The elastic theory provides an excellent description of the fluctuation spectra of pure membranes and successfully reproduces the deformation profiles of membranes around single proteins. However, its prediction for the potential of mean force between proteins is not compatible with the simulation data for large distances. The simulations show that the lipid-mediated interactions are governed by five competing factors: direct interactions; lipid-induced depletion interactions; lipid bridging; lipid packing; and a smooth long-range contribution. The mechanisms leading to hydrophobic mismatch interactions are critically analyzed.
Publishing Year
ISSN
PUB-ID

Cite this

West B, Brown FLH, Schmid F. Membrane-Protein Interactions in a Generic Coarse-Grained Model for Lipid Bilayers. Biophysical Journal. 2009;96(1):101-115.
West, B., Brown, F. L. H., & Schmid, F. (2009). Membrane-Protein Interactions in a Generic Coarse-Grained Model for Lipid Bilayers. Biophysical Journal, 96(1), 101-115. doi:10.1529/biophysj.108.138677
West, B., Brown, F. L. H., and Schmid, F. (2009). Membrane-Protein Interactions in a Generic Coarse-Grained Model for Lipid Bilayers. Biophysical Journal 96, 101-115.
West, B., Brown, F.L.H., & Schmid, F., 2009. Membrane-Protein Interactions in a Generic Coarse-Grained Model for Lipid Bilayers. Biophysical Journal, 96(1), p 101-115.
B. West, F.L.H. Brown, and F. Schmid, “Membrane-Protein Interactions in a Generic Coarse-Grained Model for Lipid Bilayers”, Biophysical Journal, vol. 96, 2009, pp. 101-115.
West, B., Brown, F.L.H., Schmid, F.: Membrane-Protein Interactions in a Generic Coarse-Grained Model for Lipid Bilayers. Biophysical Journal. 96, 101-115 (2009).
West, Beate, Brown, Frank L. H., and Schmid, Friederike. “Membrane-Protein Interactions in a Generic Coarse-Grained Model for Lipid Bilayers”. Biophysical Journal 96.1 (2009): 101-115.
This data publication is cited in the following publications:
This publication cites the following data publications:

35 Citations in Europe PMC

Data provided by Europe PubMed Central.

Quantitative modeling of membrane deformations by multihelical membrane proteins: application to G-protein coupled receptors.
Mondal S, Khelashvili G, Shan J, Andersen OS, Weinstein H., Biophys J 101(9), 2011
PMID: 22067146
Multiscale simulation of protein mediated membrane remodeling.
Ayton GS, Voth GA., Semin Cell Dev Biol 21(4), 2010
PMID: 19922811
Lipid membranes with transmembrane proteins in shear flow.
Khoshnood A, Noguchi H, Gompper G., J Chem Phys 132(2), 2010
PMID: 20095714
Coarse-grained simulations of membranes under tension.
Neder J, West B, Nielaba P, Schmid F., J Chem Phys 132(11), 2010
PMID: 20331316
Molecular simulation of the effect of cholesterol on lipid-mediated protein-protein interactions.
de Meyer FJ, Rodgers JM, Willems TF, Smit B., Biophys J 99(11), 2010
PMID: 21112287
Toy amphiphiles on the computer: What can we learn from generic models?
Schmid F., Macromol Rapid Commun 30(9-10), 2009
PMID: 21706660
Systematic multiscale simulation of membrane protein systems.
Ayton GS, Voth GA., Curr Opin Struct Biol 19(2), 2009
PMID: 19362465

83 References

Data provided by Europe PubMed Central.

Spatial and energetic-entropic decomposition of surface tension in lipid bilayers from molecular dynamics simulations
Lindahl E., Edholm O.., 2000

AUTHOR UNKNOWN, 0

AUTHOR UNKNOWN, 0
Elastic curvature constants of lipid monolayers and bilayers.
Marsh D., Chem. Phys. Lipids 144(2), 2006
PMID: 17045578
Phase behavior and induced interdigitation in bilayers studied with dissipative particle dynamics
Kranenburg M., Venturoli M., Smit B.., 2003

AUTHOR UNKNOWN, 0
Liquid phases of Langmuir monolayers
Schmid F., Schick M.., 1995

Export

0 Marked Publications

Open Data PUB

Web of Science

View record in Web of Science®

Sources

PMID: 18835907
PubMed | Europe PMC

arXiv 0809.1797

Search this title in

Google Scholar