Helicobacter exploits integrin for type IV secretion and kinase activation

Kwok T, Zabler D, Urman S, Rohde M, Hartig R, Wessler S, Misselwitz R, Berger J, Sewald N, Koenig W, Backert S (2007)
NATURE 449(7164): 862-866.

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Zeitschriftenaufsatz | Veröffentlicht | Englisch
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Abstract / Bemerkung
Integrins are important mammalian receptors involved in normal cellular functions as well as pathogenesis of chronic inflammation and cancer. We propose that integrins are exploited by the gastric pathogen and type-1 carcinogen Helicobacter pylori for injection of the bacterial oncoprotein cytotoxin-associated gene A (CagA) into gastric epithelial cells. Virulent H. pylori express a type-IV secretion pilus that injects CagA into the host cell; CagA then becomes tyrosine-phosphorylated by Src family kinases. However, the identity of the host cell receptor involved in this process has remained unknown. Here we show that the H. pylori CagL protein is a specialized adhesin that is targeted to the pilus surface, where it binds to and activates integrin alpha(5)beta(1) receptor on gastric epithelial cells through an arginine-glycine-aspartate motif. This interaction triggers CagA delivery into target cells as well as activation of focal adhesion kinase and Src. Our findings provide insights into the role of integrins in H.-pylori-induced pathogenesis. CagL may be exploited as a new molecular tool for our further understanding of integrin signalling.
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NATURE
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449
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7164
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862-866
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Kwok T, Zabler D, Urman S, et al. Helicobacter exploits integrin for type IV secretion and kinase activation. NATURE. 2007;449(7164):862-866.
Kwok, T., Zabler, D., Urman, S., Rohde, M., Hartig, R., Wessler, S., Misselwitz, R., et al. (2007). Helicobacter exploits integrin for type IV secretion and kinase activation. NATURE, 449(7164), 862-866. doi:10.1038/nature06187
Kwok, T., Zabler, D., Urman, S., Rohde, M., Hartig, R., Wessler, S., Misselwitz, R., Berger, J., Sewald, N., Koenig, W., et al. (2007). Helicobacter exploits integrin for type IV secretion and kinase activation. NATURE 449, 862-866.
Kwok, T., et al., 2007. Helicobacter exploits integrin for type IV secretion and kinase activation. NATURE, 449(7164), p 862-866.
T. Kwok, et al., “Helicobacter exploits integrin for type IV secretion and kinase activation”, NATURE, vol. 449, 2007, pp. 862-866.
Kwok, T., Zabler, D., Urman, S., Rohde, M., Hartig, R., Wessler, S., Misselwitz, R., Berger, J., Sewald, N., Koenig, W., Backert, S.: Helicobacter exploits integrin for type IV secretion and kinase activation. NATURE. 449, 862-866 (2007).
Kwok, Terry, Zabler, Dana, Urman, Sylwia, Rohde, Manfred, Hartig, Roland, Wessler, Silja, Misselwitz, Rolf, Berger, Juergen, Sewald, Norbert, Koenig, Wolfgang, and Backert, Steffen. “Helicobacter exploits integrin for type IV secretion and kinase activation”. NATURE 449.7164 (2007): 862-866.

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H. pylori isolates with amino acid sequence polymorphisms as presence of both HtrA-L171 & CagL-Y58/E59 increase the risk of gastric cancer.
Yeh YC, Kuo HY, Chang WL, Yang HB, Lu CC, Cheng HC, Wu MS, Sheu BS., J Biomed Sci 26(1), 2019
PMID: 30611258
KDM4B is a coactivator of c-Jun and involved in gastric carcinogenesis.
Wu MC, Cheng HH, Yeh TS, Li YC, Chen TJ, Sit WY, Chuu CP, Kung HJ, Chien S, Wang WC., Cell Death Dis 10(2), 2019
PMID: 30683841
Helicobacter pylori-controlled c-Abl localization promotes cell migration and limits apoptosis.
Posselt G, Wiesauer M, Chichirau BE, Engler D, Krisch LM, Gadermaier G, Briza P, Schneider S, Boccellato F, Meyer TF, Hauser-Kronberger C, Neureiter D, Müller A, Wessler S., Cell Commun Signal 17(1), 2019
PMID: 30704478
CagL polymorphisms D58/K59 are predominant in Helicobacter pylori strains isolated from Mexican patients with chronic gastritis.
Román-Román A, Martínez-Santos VI, Castañón-Sánchez CA, Albañil-Muñoz AJ, González-Mendoza P, Soto-Flores DG, Martínez-Carrillo DN, Fernández-Tilapa G., Gut Pathog 11(), 2019
PMID: 30805032
Nanoparticle binding attenuates the pathobiology of gastric cancer-associated Helicobacter pylori.
Westmeier D, Posselt G, Hahlbrock A, Bartfeld S, Vallet C, Abfalter C, Docter D, Knauer SK, Wessler S, Stauber RH., Nanoscale 10(3), 2018
PMID: 29303193
Type IV secretion in Gram-negative and Gram-positive bacteria.
Grohmann E, Christie PJ, Waksman G, Backert S., Mol Microbiol 107(4), 2018
PMID: 29235173
Beyond the Matrix: The Many Non-ECM Ligands for Integrins.
LaFoya B, Munroe JA, Miyamoto A, Detweiler MA, Crow JJ, Gazdik T, Albig AR., Int J Mol Sci 19(2), 2018
PMID: 29393909
Helicobacter pylori Type IV Secretion System and Its Adhesin Subunit, CagL, Mediate Potent Inflammatory Responses in Primary Human Endothelial Cells.
Tafreshi M, Guan J, Gorrell RJ, Chew N, Xin Y, Deswaerte V, Rohde M, Daly RJ, Peek RM, Jenkins BJ, Davies EM, Kwok T., Front Cell Infect Microbiol 8(), 2018
PMID: 29468142
Human Gut Microbiota and Gastrointestinal Cancer.
Meng C, Bai C, Brown TD, Hood LE, Tian Q., Genomics Proteomics Bioinformatics 16(1), 2018
PMID: 29474889
In Vivo Structures of the Helicobacter pylori cag Type IV Secretion System.
Chang YW, Shaffer CL, Rettberg LA, Ghosal D, Jensen GJ., Cell Rep 23(3), 2018
PMID: 29669273
The Helicobacter pylori adhesin protein HopQ exploits the dimer interface of human CEACAMs to facilitate translocation of the oncoprotein CagA.
Bonsor DA, Zhao Q, Schmidinger B, Weiss E, Wang J, Deredge D, Beadenkopf R, Dow B, Fischer W, Beckett D, Wintrode PL, Haas R, Sundberg EJ., EMBO J 37(13), 2018
PMID: 29724755
CagY-Dependent Regulation of Type IV Secretion in Helicobacter pylori Is Associated with Alterations in Integrin Binding.
Skoog EC, Morikis VA, Martin ME, Foster GA, Cai LP, Hansen LM, Li B, Gaddy JA, Simon SI, Solnick JV., MBio 9(3), 2018
PMID: 29764950
The type IV secretion system in Helicobacter pylori.
Yuan XY, Wang Y, Wang MY., Future Microbiol 13(), 2018
PMID: 29927340
Unusual Manifestation of Live Staphylococcus saprophyticus, Corynebacterium urinapleomorphum, and Helicobacter pylori in the Gallbladder with Cholecystitis.
Backert S, Tegtmeyer N, Oyarzabal OA, Osman D, Rohde M, Grützmann R, Vieth M., Int J Mol Sci 19(7), 2018
PMID: 29933576
Eosinophils suppress Th1 responses and restrict bacterially induced gastrointestinal inflammation.
Arnold IC, Artola-Borán M, Tallón de Lara P, Kyburz A, Taube C, Ottemann K, van den Broek M, Yousefi S, Simon HU, Müller A., J Exp Med 215(8), 2018
PMID: 29970473
Helicobacter: Inflammation, immunology, and vaccines.
Blosse A, Lehours P, Wilson KT, Gobert AP., Helicobacter 23 Suppl 1(), 2018
PMID: 30277626
Integrin but not CEACAM receptors are dispensable for Helicobacter pylori CagA translocation.
Zhao Q, Busch B, Jiménez-Soto LF, Ishikawa-Ankerhold H, Massberg S, Terradot L, Fischer W, Haas R., PLoS Pathog 14(10), 2018
PMID: 30365569
The Helicobacter pylori Autotransporter ImaA Tempers the Bacterium's Interaction with α5β1 Integrin.
Sause WE, Keilberg D, Aboulhouda S, Ottemann KM., Infect Immun 85(1), 2017
PMID: 27795352
DNA Transfer and Toll-like Receptor Modulation by Helicobacter pylori.
Varga MG, Peek RM., Curr Top Microbiol Immunol 400(), 2017
PMID: 28124154
Helicobacter pylori-Induced HB-EGF Upregulates Gastrin Expression via the EGF Receptor, C-Raf, Mek1, and Erk2 in the MAPK Pathway.
Gunawardhana N, Jang S, Choi YH, Hong YA, Jeon YE, Kim A, Su H, Kim JH, Yoo YJ, Merrell DS, Kim J, Cha JH., Front Cell Infect Microbiol 7(), 2017
PMID: 29379775
Biological Diversity and Evolution of Type IV Secretion Systems.
Christie PJ, Gomez Valero L, Buchrieser C., Curr Top Microbiol Immunol 413(), 2017
PMID: 29536353
Helicobacter pylori: A Paradigm Pathogen for Subverting Host Cell Signal Transmission.
Naumann M, Sokolova O, Tegtmeyer N, Backert S., Trends Microbiol 25(4), 2017
PMID: 28057411
Bacterial serine protease HtrA as a promising new target for antimicrobial therapy?
Wessler S, Schneider G, Backert S., Cell Commun Signal 15(1), 2017
PMID: 28069057
Whole Genome Sequence and Phylogenetic Analysis Show Helicobacter pylori Strains from Latin America Have Followed a Unique Evolution Pathway.
Muñoz-Ramírez ZY, Mendez-Tenorio A, Kato I, Bravo MM, Rizzato C, Thorell K, Torres R, Aviles-Jimenez F, Camorlinga M, Canzian F, Torres J., Front Cell Infect Microbiol 7(), 2017
PMID: 28293542
Proteolysis in Helicobacter pylori-Induced Gastric Cancer.
Posselt G, Crabtree JE, Wessler S., Toxins (Basel) 9(4), 2017
PMID: 28398251
Genetic variants of Helicobacter pylori type IV secretion system components CagL and CagI and their association with clinical outcomes.
Ogawa H, Iwamoto A, Tanahashi T, Okada R, Yamamoto K, Nishiumi S, Yoshida M, Azuma T., Gut Pathog 9(), 2017
PMID: 28439300
Use of chimeric type IV secretion systems to define contributions of outer membrane subassemblies for contact-dependent translocation.
Gordon JE, Costa TRD, Patel RS, Gonzalez-Rivera C, Sarkar MK, Orlova EV, Waksman G, Christie PJ., Mol Microbiol 105(2), 2017
PMID: 28452085
Functional interaction and structural characteristics of unique components of Helicobacter pylori T4SS.
Merino E, Flores-Encarnación M, Aguilar-Gutiérrez GR., FEBS J 284(21), 2017
PMID: 28470874
Subversion of host kinases: a key network in cellular signaling hijacked by Helicobacter pylori CagA.
Tegtmeyer N, Neddermann M, Asche CI, Backert S., Mol Microbiol 105(3), 2017
PMID: 28508421
Targeting the Mucosal Barrier: How Pathogens Modulate the Cellular Polarity Network.
Ruch TR, Engel JN., Cold Spring Harb Perspect Biol 9(6), 2017
PMID: 28193722
Association of heterogenicity of Helicobacter pylori cag pathogenicity island with peptic ulcer diseases and gastric cancer.
Khatoon J, Prasad KN, Prakash Rai R, Ghoshal UC, Krishnani N., Br J Biomed Sci 74(3), 2017
PMID: 28571523
Aggregatibacter actinomycetemcomitans regulates the expression of integrins and reduces cell adhesion via integrin α5 in human gingival epithelial cells.
Kochi S, Yamashiro K, Hongo S, Yamamoto T, Ugawa Y, Shimoe M, Kawamura M, Hirata-Yoshihara C, Ideguchi H, Maeda H, Takashiba S., Mol Cell Biochem 436(1-2), 2017
PMID: 28593565
Helicobacter pylori vacA genotype is a predominant determinant of immune response to Helicobacter pylori CagA.
Link A, Langner C, Schirrmeister W, Habendorf W, Weigt J, Venerito M, Tammer I, Schlüter D, Schlaermann P, Meyer TF, Wex T, Malfertheiner P., World J Gastroenterol 23(26), 2017
PMID: 28765692
Helicobacter pylori Makes a Molecular Incision to Gain Epithelial Entry.
Noto JM, Peek RM., Cell Host Microbe 22(4), 2017
PMID: 29024639
KCTD5 and Ubiquitin Proteasome Signaling Are Required for Helicobacter pylori Adherence.
Álvarez A, Uribe F, Canales J, Romero C, Soza A, Peña MA, Antonelli M, Almarza O, Cerda O, Toledo H., Front Cell Infect Microbiol 7(), 2017
PMID: 29114497
A bacterial toxin-antitoxin module is the origin of inter-bacterial and inter-kingdom effectors of Bartonella.
Harms A, Liesch M, Körner J, Québatte M, Engel P, Dehio C., PLoS Genet 13(10), 2017
PMID: 29073136
Molecular dissection of protein-protein interactions between integrin α5β1 and the Helicobacter pylori Cag type IV secretion system.
Koelblen T, Bergé C, Cherrier MV, Brillet K, Jimenez-Soto L, Ballut L, Takagi J, Montserret R, Rousselle P, Fischer W, Haas R, Fronzes R, Terradot L., FEBS J 284(23), 2017
PMID: 29055076
Pathobiology of Helicobacter pylori-Induced Gastric Cancer.
Amieva M, Peek RM., Gastroenterology 150(1), 2016
PMID: 26385073
Systems-wide analyses of mucosal immune responses to Helicobacter pylori at the interface between pathogenicity and symbiosis.
Kronsteiner B, Bassaganya-Riera J, Philipson C, Viladomiu M, Carbo A, Abedi V, Hontecillas R., Gut Microbes 7(1), 2016
PMID: 26939848
Molecular and Structural Analysis of the Helicobacter pylori cag Type IV Secretion System Core Complex.
Frick-Cheng AE, Pyburn TM, Voss BJ, McDonald WH, Ohi MD, Cover TL., MBio 7(1), 2016
PMID: 26758182
Early Molecular Events in Murine Gastric Epithelial Cells Mediated by Helicobacter pylori CagA.
Banerjee A, Basu M, Blanchard TG, Chintalacharuvu SR, Guang W, Lillehoj EP, Czinn SJ., Helicobacter 21(5), 2016
PMID: 26817586
Dynamic interplay between adhesion surfaces in carcinomas: Cell-cell and cell-matrix crosstalk.
Smith YE, Vellanki SH, Hopkins AM., World J Biol Chem 7(1), 2016
PMID: 26981196
How Helicobacter pylori senses, targets and interacts with the gastric epithelium.
Keilberg D, Ottemann KM., Environ Microbiol 18(3), 2016
PMID: 26768806
Helicobacter pylori CagL Hypervariable Motif: A Global Analysis of Geographical Diversity and Association With Gastric Cancer.
Gorrell RJ, Zwickel N, Reynolds J, Bulach D, Kwok T., J Infect Dis 213(12), 2016
PMID: 26908724
The Helicobacter pylori cytotoxin CagA is essential for suppressing host heat shock protein expression.
J Lang B, J Gorrell R, Tafreshi M, Hatakeyama M, Kwok T, T Price J., Cell Stress Chaperones 21(3), 2016
PMID: 26928021
Moonlighting of Helicobacter pylori catalase protects against complement-mediated killing by utilising the host molecule vitronectin.
Richter C, Mukherjee O, Ermert D, Singh B, Su YC, Agarwal V, Blom AM, Riesbeck K., Sci Rep 6(), 2016
PMID: 27087644
Lactobacilli Reduce Helicobacter pylori Attachment to Host Gastric Epithelial Cells by Inhibiting Adhesion Gene Expression.
de Klerk N, Maudsdotter L, Gebreegziabher H, Saroj SD, Eriksson B, Eriksson OS, Roos S, Lindén S, Sjölinder H, Jonsson AB., Infect Immun 84(5), 2016
PMID: 26930708
Peptidomimetic Small Molecules Disrupt Type IV Secretion System Activity in Diverse Bacterial Pathogens.
Shaffer CL, Good JA, Kumar S, Krishnan KS, Gaddy JA, Loh JT, Chappell J, Almqvist F, Cover TL, Hadjifrangiskou M., MBio 7(2), 2016
PMID: 27118587
Mechanism and Function of Type IV Secretion During Infection of the Human Host.
Gonzalez-Rivera C, Bhatty M, Christie PJ., Microbiol Spectr 4(3), 2016
PMID: 27337453
Anti-Helicobacter pylori activity of crude N-acetylneuraminic acid isolated from glycomacropeptide of whey.
Kim DJ, Kang MJ, Choi JA, Na DS, Kim JB, Na CS, Park JH., Lab Anim Res 32(2), 2016
PMID: 27382378
The Role of CagA in the Gastric Biology of Helicobacter pylori.
Backert S, Blaser MJ., Cancer Res 76(14), 2016
PMID: 27655809
Allosteric Regulation of Fibronectin/α5β1 Interaction by Fibronectin-Binding MSCRAMMs.
Liang X, Garcia BL, Visai L, Prabhakaran S, Meenan NA, Potts JR, Humphries MJ, Höök M., PLoS One 11(7), 2016
PMID: 27434228
A C-Terminal Coiled-Coil Region of CagL is Responsible for Helicobacter Pylori-Induced Il-8 Expression.
Wiedemann T, Hofbaur S, Loell E, Rieder G., Eur J Microbiol Immunol (Bp) 6(3), 2016
PMID: 27766167
Systematic analysis of phosphotyrosine antibodies recognizing single phosphorylated EPIYA-motifs in CagA of East Asian-type Helicobacter pylori strains.
Lind J, Backert S, Hoffmann R, Eichler J, Yamaoka Y, Perez-Perez GI, Torres J, Sticht H, Tegtmeyer N., BMC Microbiol 16(1), 2016
PMID: 27590005
Proteomic discovery of host kinase signaling in bacterial infections.
Richter E, Mostertz J, Hochgräfe F., Proteomics Clin Appl 10(9-10), 2016
PMID: 27440122
Flagellin FliC Phosphorylation Affects Type 2 Protease Secretion and Biofilm Dispersal in Pseudomonas aeruginosa PAO1.
Suriyanarayanan T, Periasamy S, Lin MH, Ishihama Y, Swarup S., PLoS One 11(10), 2016
PMID: 27701473
Adhesion and Invasion of Gastric Mucosa Epithelial Cells by Helicobacter pylori.
Huang Y, Wang QL, Cheng DD, Xu WT, Lu NH., Front Cell Infect Microbiol 6(), 2016
PMID: 27921009
Against the tide: the role of bacterial adhesion in host colonization.
Stones DH, Krachler AM., Biochem Soc Trans 44(6), 2016
PMID: 27913666
Helicobacter pylori VacA, acting through receptor protein tyrosine phosphatase α, is crucial for CagA phosphorylation in human duodenum carcinoma cell line AZ-521.
Nakano M, Yahiro K, Yamasaki E, Kurazono H, Akada J, Yamaoka Y, Niidome T, Hatakeyama M, Suzuki H, Yamamoto T, Moss J, Isomoto H, Hirayama T., Dis Model Mech 9(12), 2016
PMID: 27935824
Helicobacter pylori CagA induced interleukin-8 secretion in gastric epithelial cells.
Fazeli Z, Alebouyeh M, Rezaei Tavirani M, Azimirad M, Yadegar A., Gastroenterol Hepatol Bed Bench 9(suppl1), 2016
PMID: 28224027
Epithelial cell ADAM17 activation by Helicobacter pylori: role of ADAM17 C-terminus and Threonine-735 phosphorylation.
McClurg UL, Danjo K, King HO, Scott GB, Robinson PA, Crabtree JE., Microbes Infect 17(3), 2015
PMID: 25499189
New mechanistic insights of integrin β1 in breast cancer bone colonization.
Thibaudeau L, Taubenberger AV, Theodoropoulos C, Holzapfel BM, Ramuz O, Straub M, Hutmacher DW., Oncotarget 6(1), 2015
PMID: 25426561
Structural Biology of Bacterial Type IV Secretion Systems.
Chandran Darbari V, Waksman G., Annu Rev Biochem 84(), 2015
PMID: 26034891
Crystal structure of CagL from Helicobacter pylori K74 strain.
Choi JM, Choi YH, Sudhanva MS, Devakumar S, Lee KH, Cha JH, Lee SH., Biochem Biophys Res Commun 460(4), 2015
PMID: 25839651
Integrin engagement by the helical RGD motif of the Helicobacter pylori CagL protein is regulated by pH-induced displacement of a neighboring helix.
Bonsor DA, Pham KT, Beadenkopf R, Diederichs K, Haas R, Beckett D, Fischer W, Sundberg EJ., J Biol Chem 290(20), 2015
PMID: 25837254
Helicobacter pylori virulence factors affecting gastric proton pump expression and acid secretion.
Hammond CE, Beeson C, Suarez G, Peek RM, Backert S, Smolka AJ., Am J Physiol Gastrointest Liver Physiol 309(3), 2015
PMID: 26045613
The Influence of the Gut Microbiome on Obesity, Metabolic Syndrome and Gastrointestinal Disease.
Parekh PJ, Balart LA, Johnson DA., Clin Transl Gastroenterol 6(), 2015
PMID: 26087059
CagA of Helicobacter pylori interacts with and inhibits the serine-threonine kinase PRK2.
Mishra JP, Cohen D, Zamperone A, Nesic D, Muesch A, Stein M., Cell Microbiol 17(11), 2015
PMID: 26041307
Helicobacter pylori virulence factor CagA promotes tumorigenesis of gastric cancer via multiple signaling pathways.
Yong X, Tang B, Li BS, Xie R, Hu CJ, Luo G, Qin Y, Dong H, Yang SM., Cell Commun Signal 13(), 2015
PMID: 26160167
Helicobacter pylori virulence factors in development of gastric carcinoma.
Wang MY, Liu XF, Gao XZ., Future Microbiol 10(9), 2015
PMID: 26346770
H. pylori-Induced DNA Strand Breaks Are Introduced by Nucleotide Excision Repair Endonucleases and Promote NF-κB Target Gene Expression.
Hartung ML, Gruber DC, Koch KN, Grüter L, Rehrauer H, Tegtmeyer N, Backert S, Müller A., Cell Rep 13(1), 2015
PMID: 26411687
Biochemical Analysis of CagE: A VirB4 Homologue of Helicobacter pylori Cag-T4SS.
Shariq M, Kumar N, Kumari R, Kumar A, Subbarao N, Mukhopadhyay G., PLoS One 10(11), 2015
PMID: 26565397
Gastrointestinal malignancy and the microbiome.
Abreu MT, Peek RM., Gastroenterology 146(6), 2014
PMID: 24406471
Structural and functional aspects of the Helicobacter pylori secretome.
Zanotti G, Cendron L., World J Gastroenterol 20(6), 2014
PMID: 24587618
Exploring alternative treatments for Helicobacter pylori infection.
Ayala G, Escobedo-Hinojosa WI, de la Cruz-Herrera CF, Romero I., World J Gastroenterol 20(6), 2014
PMID: 24587621
Helicobacter pylori-induced posttranscriptional regulation of H-K-ATPase α-subunit gene expression by miRNA.
Zhang YM, Noto JM, Hammond CE, Barth JL, Argraves WS, Backert S, Peek RM, Smolka AJ., Am J Physiol Gastrointest Liver Physiol 306(7), 2014
PMID: 24503769
DNA transfer in the gastric pathogen Helicobacter pylori.
Fernandez-Gonzalez E, Backert S., J Gastroenterol 49(4), 2014
PMID: 24515309
Analysis of surface-exposed outer membrane proteins in Helicobacter pylori.
Voss BJ, Gaddy JA, McDonald WH, Cover TL., J Bacteriol 196(13), 2014
PMID: 24769695
Factors that mediate colonization of the human stomach by Helicobacter pylori.
Dunne C, Dolan B, Clyne M., World J Gastroenterol 20(19), 2014
PMID: 24914320
Systematic analysis of phosphotyrosine antibodies recognizing single phosphorylated EPIYA-motifs in CagA of Western-type Helicobacter pylori strains.
Lind J, Backert S, Pfleiderer K, Berg DE, Yamaoka Y, Sticht H, Tegtmeyer N., PLoS One 9(5), 2014
PMID: 24800748
Clinical relevance of cagL gene and virulence genotypes with disease outcomes in a Helicobacter pylori infected population from Iran.
Yadegar A, Mobarez AM, Alebouyeh M, Mirzaei T, Kwok T, Zali MR., World J Microbiol Biotechnol 30(9), 2014
PMID: 24854336
Helicobacter pylori virulence and cancer pathogenesis.
Yamaoka Y, Graham DY., Future Oncol 10(8), 2014
PMID: 25052757
Genes required for assembly of pili associated with the Helicobacter pylori cag type IV secretion system.
Johnson EM, Gaddy JA, Voss BJ, Hennig EE, Cover TL., Infect Immun 82(8), 2014
PMID: 24891108
The role of epithelial tight junctions involved in pathogen infections.
Lu RY, Yang WX, Yang WX, Hu YJ., Mol Biol Rep 41(10), 2014
PMID: 24965148
The potential utility of chitosan micro/nanoparticles in the treatment of gastric infection.
Gonçalves IC, Henriques PC, Seabra CL, Martins MC., Expert Rev Anti Infect Ther 12(8), 2014
PMID: 24981812
Analysis of T4SS-induced signaling by H. pylori using quantitative phosphoproteomics.
Glowinski F, Holland C, Thiede B, Jungblut PR, Meyer TF., Front Microbiol 5(), 2014
PMID: 25101063
Helicobacter pylori promotes epithelial-mesenchymal transition in gastric cancer by downregulating programmed cell death protein 4 (PDCD4).
Yu H, Zeng J, Liang X, Wang W, Zhou Y, Sun Y, Liu S, Li W, Chen C, Jia J., PLoS One 9(8), 2014
PMID: 25144746
Effect of Helicobacter pylori on gastric epithelial cells.
Alzahrani S, Lina TT, Gonzalez J, Pinchuk IV, Beswick EJ, Reyes VE., World J Gastroenterol 20(36), 2014
PMID: 25278677
Helicobacter pylori cagL amino acid polymorphisms and its association with gastroduodenal diseases.
Shukla SK, Prasad KN, Tripathi A, Jaiswal V, Khatoon J, Ghsohal UC, Krishnani N, Husain N., Gastric Cancer 16(3), 2013
PMID: 22941498
Haem oxygenase-1 inhibits phosphorylation of the Helicobacter pylori oncoprotein CagA in gastric epithelial cells.
Gobert AP, Verriere T, de Sablet T, Peek RM, Chaturvedi R, Wilson KT., Cell Microbiol 15(1), 2013
PMID: 23051580
A novel NOD1- and CagA-independent pathway of interleukin-8 induction mediated by the Helicobacter pylori type IV secretion system.
Gorrell RJ, Guan J, Xin Y, Tafreshi MA, Hutton ML, McGuckin MA, Ferrero RL, Kwok T., Cell Microbiol 15(4), 2013
PMID: 23107019
Expression of CagL from Helicobacter pylori and Preliminary Study of its Biological Function.
Wang H, Huang S, Zhao J, Han J, Guan X, Shao S., Indian J Microbiol 53(1), 2013
PMID: 24426076
Adherens junctions as targets of microorganisms: a focus on Helicobacter pylori.
Costa AM, Leite M, Seruca R, Figueiredo C., FEBS Lett 587(3), 2013
PMID: 23262219
Integrin-mediated internalization of Staphylococcus aureus does not require vinculin.
Borisova M, Shi Y, Buntru A, Wörner S, Ziegler WH, Hauck CR., BMC Cell Biol 14(), 2013
PMID: 23294665
Type IV secretion machinery: molecular architecture and function.
Chandran V., Biochem Soc Trans 41(1), 2013
PMID: 23356253
Functional plasticity in the type IV secretion system of Helicobacter pylori.
Barrozo RM, Cooke CL, Hansen LM, Lam AM, Gaddy JA, Johnson EM, Cariaga TA, Suarez G, Peek RM, Cover TL, Solnick JV., PLoS Pathog 9(2), 2013
PMID: 23468628
Helicobacter pylori in gastric carcinogenesis: mechanisms.
Wroblewski LE, Peek RM., Gastroenterol Clin North Am 42(2), 2013
PMID: 23639641
Helicobacter pylori initiates a mesenchymal transition through ZEB1 in gastric epithelial cells.
Baud J, Varon C, Chabas S, Chambonnier L, Darfeuille F, Staedel C., PLoS One 8(4), 2013
PMID: 23565224
Distribution of Helicobacter pylori virulence markers in patients with gastroduodenal diseases in a region at high risk of gastric cancer.
Wang MY, Chen C, Gao XZ, Li J, Yue J, Ling F, Wang XC, Shao SH., Microb Pathog 59-60(), 2013
PMID: 23583809
Life in the human stomach: persistence strategies of the bacterial pathogen Helicobacter pylori.
Salama NR, Hartung ML, Müller A., Nat Rev Microbiol 11(6), 2013
PMID: 23652324
Genome sequences of 65 Helicobacter pylori strains isolated from asymptomatic individuals and patients with gastric cancer, peptic ulcer disease, or gastritis.
Blanchard TG, Czinn SJ, Correa P, Nakazawa T, Keelan M, Morningstar L, Santana-Cruz I, Maroo A, McCracken C, Shefchek K, Daugherty S, Song Y, Fraser CM, Fricke WF., Pathog Dis 68(2), 2013
PMID: 23661595
Delineating breast cancer cell interactions with engineered bone microenvironments.
Taubenberger AV, Quent VM, Thibaudeau L, Clements JA, Hutmacher DW., J Bone Miner Res 28(6), 2013
PMID: 23362043
A systematic approach toward stabilization of CagL, a protein antigen from Helicobacter pylori that is a candidate subunit vaccine.
Choudhari SP, Pendleton KP, Ramsey JD, Blanchard TG, Picking WD., J Pharm Sci 102(8), 2013
PMID: 23794457
Helicobacter pylori outer membrane protein HopQ identified as a novel T4SS-associated virulence factor.
Belogolova E, Bauer B, Pompaiah M, Asakura H, Brinkman V, Ertl C, Bartfeld S, Nechitaylo TY, Haas R, Machuy N, Salama N, Churin Y, Meyer TF., Cell Microbiol 15(11), 2013
PMID: 23782461
Induction of premalignant host responses by cathepsin x/z-deficiency in Helicobacter pylori-infected mice.
Krueger S, Bernhardt A, Kalinski T, Baldensperger M, Zeh M, Teller A, Adolf D, Reinheckel T, Roessner A, Kuester D., PLoS One 8(7), 2013
PMID: 23936173
Electron microscopic, genetic and protein expression analyses of Helicobacter acinonychis strains from a Bengal tiger.
Tegtmeyer N, Rivas Traverso F, Rohde M, Oyarzabal OA, Lehn N, Schneider-Brachert W, Ferrero RL, Fox JG, Berg DE, Backert S., PLoS One 8(8), 2013
PMID: 23940723
Helicobacter pylori downregulates expression of human β-defensin 1 in the gastric mucosa in a type IV secretion-dependent fashion.
Patel SR, Smith K, Letley DP, Cook KW, Memon AA, Ingram RJ, Staples E, Backert S, Zaitoun AM, Atherton JC, Robinson K., Cell Microbiol 15(12), 2013
PMID: 23870035
Dynamics of the Cag-type IV secretion system of Helicobacter pylori as studied by bacterial co-infections.
Jiménez-Soto LF, Clausen S, Sprenger A, Ertl C, Haas R., Cell Microbiol 15(11), 2013
PMID: 23844976
Inflammation, immunity, vaccines for Helicobacter pylori infection.
Koch M, Meyer TF, Moss SF., Helicobacter 18 Suppl 1(), 2013
PMID: 24011240
ITGA1 polymorphisms and haplotypes are associated with gastric cancer risk in a Korean population.
Yim DH, Zhang YW, Eom SY, Moon SI, Yun HY, Song YJ, Youn SJ, Hyun T, Park JS, Kim BS, Lee JY, Kim YD, Kim H., World J Gastroenterol 19(35), 2013
PMID: 24124332
Cag type IV secretion system: CagI independent bacterial surface localization of CagA.
Kumar N, Shariq M, Kumari R, Tyagi RK, Mukhopadhyay G., PLoS One 8(9), 2013
PMID: 24040297
A helical RGD motif promoting cell adhesion: crystal structures of the Helicobacter pylori type IV secretion system pilus protein CagL.
Barden S, Lange S, Tegtmeyer N, Conradi J, Sewald N, Backert S, Niemann HH., Structure 21(11), 2013
PMID: 24076404
Cytokinins secreted by Agrobacterium promote transformation by repressing a plant myb transcription factor.
Sardesai N, Lee LY, Chen H, Yi H, Olbricht GR, Stirnberg A, Jeffries J, Xiong K, Doerge RW, Gelvin SB., Sci Signal 6(302), 2013
PMID: 24255177
Cyclic RGD peptides interfere with binding of the Helicobacter pylori protein CagL to integrins αVβ3 and α5β1.
Conradi J, Huber S, Gaus K, Mertink F, Royo Gracia S, Strijowski U, Backert S, Sewald N., Amino Acids 43(1), 2012
PMID: 21915696
Characterization of CagI in the cag pathogenicity island of Helicobacter pylori.
Wang H, Han J, Chen D, Duan X, Gao X, Wang X, Shao S., Curr Microbiol 64(2), 2012
PMID: 22109855
In vivo expression of Helicobacter pylori virulence genes in patients with gastritis, ulcer, and gastric cancer.
Avilés-Jiménez F, Reyes-Leon A, Nieto-Patlán E, Hansen LM, Burgueño J, Ramos IP, Camorlinga-Ponce M, Bermúdez H, Blancas JM, Cabrera L, Ribas-Aparicio RM, Solnick JV, Torres-López J., Infect Immun 80(2), 2012
PMID: 22124657
The Helicobacter pylori cag Pathogenicity Island.
Noto JM, Peek RM., Methods Mol Biol 921(), 2012
PMID: 23015490
Variations in Helicobacter pylori cytotoxin-associated genes and their influence in progression to gastric cancer: implications for prevention.
Rizzato C, Torres J, Plummer M, Muñoz N, Franceschi S, Camorlinga-Ponce M, Fuentes-Pananá EM, Canzian F, Kato I., PLoS One 7(1), 2012
PMID: 22235308
Alterations in Helicobacter pylori triggered by contact with gastric epithelial cells.
Johnson EM, Gaddy JA, Cover TL., Front Cell Infect Microbiol 2(), 2012
PMID: 22919609
Phosphorylation of the gastric tumor suppressor RUNX3 following H. pylori infection results in its localization to the cytoplasm.
Cinghu S, Goh YM, Oh BC, Lee YS, Lee OJ, Devaraj H, Bae SC., J Cell Physiol 227(3), 2012
PMID: 21567391
c-Src and c-Abl kinases control hierarchic phosphorylation and function of the CagA effector protein in Western and East Asian Helicobacter pylori strains.
Mueller D, Tegtmeyer N, Brandt S, Yamaoka Y, De Poire E, Sgouras D, Wessler S, Torres J, Smolka A, Backert S., J Clin Invest 122(4), 2012
PMID: 22378042
Effects of cholesterol on Helicobacter pylori growth and virulence properties in vitro.
Jiménez-Soto LF, Rohrer S, Jain U, Ertl C, Sewald X, Haas R., Helicobacter 17(2), 2012
PMID: 22404444
CagI is an essential component of the Helicobacter pylori Cag type IV secretion system and forms a complex with CagL.
Pham KT, Weiss E, Jiménez Soto LF, Breithaupt U, Haas R, Fischer W., PLoS One 7(4), 2012
PMID: 22493745
How Helicobacter pylori infection controls gastric acid secretion.
Smolka AJ, Backert S., J Gastroenterol 47(6), 2012
PMID: 22565637
An RGD helper sequence in CagL of Helicobacter pylori assists in interactions with integrins and injection of CagA.
Conradi J, Tegtmeyer N, Woźna M, Wissbrock M, Michalek C, Gagell C, Cover TL, Frank R, Sewald N, Backert S., Front Cell Infect Microbiol 2(), 2012
PMID: 22919661
Live Helicobacter pylori in the root canal of endodontic-infected deciduous teeth.
Hirsch C, Tegtmeyer N, Rohde M, Rowland M, Oyarzabal OA, Backert S., J Gastroenterol 47(8), 2012
PMID: 22722905
Structure of the VirB4 ATPase, alone and bound to the core complex of a type IV secretion system.
Walldén K, Williams R, Yan J, Lian PW, Wang L, Thalassinos K, Orlova EV, Waksman G., Proc Natl Acad Sci U S A 109(28), 2012
PMID: 22745169
Helicobacter pylori CagA tertiary structure reveals functional insights.
Backert S, Tegtmeyer N., Cell Host Microbe 12(1), 2012
PMID: 22817982
Tertiary structure-function analysis reveals the pathogenic signaling potentiation mechanism of Helicobacter pylori oncogenic effector CagA.
Hayashi T, Senda M, Morohashi H, Higashi H, Horio M, Kashiba Y, Nagase L, Sasaya D, Shimizu T, Venugopalan N, Kumeta H, Noda NN, Inagaki F, Senda T, Hatakeyama M., Cell Host Microbe 12(1), 2012
PMID: 22817985
Exploitation of integrin function by pathogenic microbes.
Hauck CR, Borisova M, Muenzner P., Curr Opin Cell Biol 24(5), 2012
PMID: 22884865
Structural insights into Helicobacter pylori oncoprotein CagA interaction with β1 integrin.
Kaplan-Türköz B, Jiménez-Soto LF, Dian C, Ertl C, Remaut H, Louche A, Tosi T, Haas R, Terradot L., Proc Natl Acad Sci U S A 109(36), 2012
PMID: 22908298
Subversion of phagocytosis for pathogen survival.
Sarantis H, Grinstein S., Cell Host Microbe 12(4), 2012
PMID: 23084912
Life at the margins: modulation of attachment proteins in Helicobacter pylori.
Moore ME, Borén T, Solnick JV., Gut Microbes 2(1), 2011
PMID: 21637017
A novel inhibitory domain of Helicobacter pylori protein CagA reduces CagA effects on host cell biology.
Pelz C, Steininger S, Weiss C, Coscia F, Vogelmann R., J Biol Chem 286(11), 2011
PMID: 21212271
Architecture of the Helicobacter pylori Cag-type IV secretion system.
Terradot L, Waksman G., FEBS J 278(8), 2011
PMID: 21352491
Molecular cross-talk between Helicobacter pylori and human gastric mucosa.
Ricci V, Romano M, Boquet P., World J Gastroenterol 17(11), 2011
PMID: 21472096
Integrin-mediated type IV secretion by Helicobacter: what makes it tick?
Schuelein R, Everingham P, Kwok T., Trends Microbiol 19(5), 2011
PMID: 21371889
Helicobacter pylori induction of eosinophil migration is mediated by the cag pathogenicity island via microbial-epithelial interactions.
Nagy TA, Allen SS, Wroblewski LE, Flaherty DK, Slaughter JC, Perez-Perez G, Israel DA, Peek RM., Am J Pathol 178(4), 2011
PMID: 21406172
Complex cellular responses of Helicobacter pylori-colonized gastric adenocarcinoma cells.
Schneider S, Carra G, Sahin U, Hoy B, Rieder G, Wessler S., Infect Immun 79(6), 2011
PMID: 21402757
Control of host cell phosphorylation by legionella pneumophila.
Haenssler E, Isberg RR., Front Microbiol 2(), 2011
PMID: 21747787
BabA-mediated adherence is a potentiator of the Helicobacter pylori type IV secretion system activity.
Ishijima N, Suzuki M, Suzuki M, Ashida H, Ichikawa Y, Kanegae Y, Saito I, Borén T, Haas R, Sasakawa C, Mimuro H., J Biol Chem 286(28), 2011
PMID: 21596743
Serine phosphorylation of cortactin controls focal adhesion kinase activity and cell scattering induced by Helicobacter pylori.
Tegtmeyer N, Wittelsberger R, Hartig R, Wessler S, Martinez-Quiles N, Backert S., Cell Host Microbe 9(6), 2011
PMID: 21669400
Paxillin is a novel cellular target for converging Helicobacter pylori-induced cellular signaling.
Tabassam FH, Graham DY, Yamaoka Y., Am J Physiol Gastrointest Liver Physiol 301(4), 2011
PMID: 21757638
Dual roles of CagA protein in Helicobacterpylori-induced chronic gastritis in mice.
Kido M, Watanabe N, Aoki N, Iwamoto S, Nishiura H, Maruoka R, Ikeda A, Azuma T, Chiba T., Biochem Biophys Res Commun 412(2), 2011
PMID: 21820415
Helicobacter pylori activates calpain via toll-like receptor 2 to disrupt adherens junctions in human gastric epithelial cells.
O'Connor PM, Lapointe TK, Jackson S, Beck PL, Jones NL, Buret AG., Infect Immun 79(10), 2011
PMID: 21825064
Helicobacter pylori CagA-mediated IL-8 induction in gastric epithelial cells is cholesterol-dependent and requires the C-terminal tyrosine phosphorylation-containing domain.
Lai CH, Wang HJ, Chang YC, Hsieh WC, Lin HJ, Tang CH, Sheu JJ, Lin CJ, Yang MS, Tseng SF, Wang WC., FEMS Microbiol Lett 323(2), 2011
PMID: 22092715
Helicobacter pylori exploits a unique repertoire of type IV secretion system components for pilus assembly at the bacteria-host cell interface.
Shaffer CL, Gaddy JA, Loh JT, Johnson EM, Hill S, Hennig EE, McClain MS, McDonald WH, Cover TL., PLoS Pathog 7(9), 2011
PMID: 21909278
Bacterial Pili exploit integrin machinery to promote immune activation and efficient blood-brain barrier penetration.
Banerjee A, Kim BJ, Carmona EM, Cutting AS, Gurney MA, Carlos C, Feuer R, Prasadarao NV, Doran KS., Nat Commun 2(), 2011
PMID: 21897373
Helicobacter pylori interferes with an embryonic stem cell micro RNA cluster to block cell cycle progression.
Belair C, Baud J, Chabas S, Sharma CM, Vogel J, Staedel C, Darfeuille F., Silence 2(1), 2011
PMID: 22027184
"Targeted disruption of the epithelial-barrier by Helicobacter pylori".
Wroblewski LE, Peek RM., Cell Commun Signal 9(1), 2011
PMID: 22044698
Major host factors involved in epithelial cell invasion of Campylobacter jejuni: role of fibronectin, integrin beta1, FAK, Tiam-1, and DOCK180 in activating Rho GTPase Rac1.
Boehm M, Krause-Gruszczynska M, Rohde M, Tegtmeyer N, Takahashi S, Oyarzabal OA, Backert S., Front Cell Infect Microbiol 1(), 2011
PMID: 22919583
The signaling pathway of Campylobacter jejuni-induced Cdc42 activation: Role of fibronectin, integrin beta1, tyrosine kinases and guanine exchange factor Vav2.
Krause-Gruszczynska M, Boehm M, Rohde M, Tegtmeyer N, Takahashi S, Buday L, Oyarzabal OA, Backert S., Cell Commun Signal 9(), 2011
PMID: 22204307
Helicobacter pylori CagA upregulation of CIP2A is dependent on the Src and MEK/ERK pathways.
Zhao D, Liu Z, Ding J, Li W, Sun Y, Yu H, Zhou Y, Zeng J, Chen C, Jia J., J Med Microbiol 59(pt 3), 2010
PMID: 19959630
Helicobacter pylori colonization of the human gastric epithelium: a bug's first step is a novel target for us.
Sheu BS, Yang HB, Yeh YC, Wu JJ., J Gastroenterol Hepatol 25(1), 2010
PMID: 20136973
Bacterial contact-dependent delivery systems.
Hayes CS, Aoki SK, Low DA., Annu Rev Genet 44(), 2010
PMID: 21047256
Role of Helicobacter pylori infection in gastric cancer pathogenesis: a chance for prevention.
Malfertheiner P, Bornschein J, Selgrad M., J Dig Dis 11(1), 2010
PMID: 20132425
PKA-mediated phosphorylation of EPEC-Tir at serine residues 434 and 463: A novel pathway in regulating Rac1 GTPase function.
Backert S, Kenny B, Gerhard R, Tegtmeyer N, Brandt S., Gut Microbes 1(2), 2010
PMID: 21326916
Surreptitious manipulation of the human host by Helicobacter pylori.
Israel DA, Peek RM., Gut Microbes 1(2), 2010
PMID: 20976041
Helicobacter pylori induces miR-155 in T cells in a cAMP-Foxp3-dependent manner.
Fassi Fehri L, Koch M, Belogolova E, Khalil H, Bolz C, Kalali B, Mollenkopf HJ, Beigier-Bompadre M, Karlas A, Schneider T, Churin Y, Gerhard M, Meyer TF., PLoS One 5(3), 2010
PMID: 20209161
Helicobacter pylori CagL activates ADAM17 to induce repression of the gastric H, K-ATPase alpha subunit.
Saha A, Backert S, Hammond CE, Gooz M, Smolka AJ., Gastroenterology 139(1), 2010
PMID: 20303353
Clinical relevance of cagPAI intactness in Helicobacter pylori isolates from Vietnam.
Nguyen LT, Uchida T, Tsukamoto Y, Trinh TD, Ta L, Mai HB, Le HS, Ho DQ, Hoang HH, Matsuhisa T, Okimoto T, Kodama M, Murakami K, Fujioka T, Yamaoka Y, Moriyama M., Eur J Clin Microbiol Infect Dis 29(6), 2010
PMID: 20372956
Muc1 cell surface mucin attenuates epithelial inflammation in response to a common mucosal pathogen.
Guang W, Ding H, Czinn SJ, Kim KC, Blanchard TG, Lillehoj EP., J Biol Chem 285(27), 2010
PMID: 20430889
Helicobacter pylori exploits host membrane phosphatidylserine for delivery, localization, and pathophysiological action of the CagA oncoprotein.
Murata-Kamiya N, Kikuchi K, Hayashi T, Higashi H, Hatakeyama M., Cell Host Microbe 7(5), 2010
PMID: 20478541
A small fibronectin-mimicking protein from bacteria induces cell spreading and focal adhesion formation.
Tegtmeyer N, Hartig R, Delahay RM, Rohde M, Brandt S, Conradi J, Takahashi S, Smolka AJ, Sewald N, Backert S., J Biol Chem 285(30), 2010
PMID: 20507990
Helicobacter pylori: gastric cancer and beyond.
Polk DB, Peek RM., Nat Rev Cancer 10(6), 2010
PMID: 20495574
Integrin receptors play a role in the internalin B-dependent entry of Listeria monocytogenes into host cells.
Auriemma C, Viscardi M, Tafuri S, Pavone LM, Capuano F, Rinaldi L, Della Morte R, Iovane G, Staiano N., Cell Mol Biol Lett 15(3), 2010
PMID: 20526749
Helicobacter pylori represses proton pump expression and inhibits acid secretion in human gastric mucosa.
Saha A, Hammond CE, Beeson C, Peek RM, Smolka AJ., Gut 59(7), 2010
PMID: 20581234
Bacterial interactions with the host epithelium.
Kim M, Ashida H, Ogawa M, Yoshikawa Y, Mimuro H, Sasakawa C., Cell Host Microbe 8(1), 2010
PMID: 20638639
Role of innate immunity in Helicobacter pylori-induced gastric malignancy.
Peek RM, Fiske C, Wilson KT., Physiol Rev 90(3), 2010
PMID: 20664074
Type IV secretion systems: versatility and diversity in function.
Wallden K, Rivera-Calzada A, Waksman G., Cell Microbiol 12(9), 2010
PMID: 20642798
Helicobacter pylori CagA protein polymorphisms and their lack of association with pathogenesis.
Acosta N, Quiroga A, Delgado P, Bravo MM, Jaramillo C., World J Gastroenterol 16(31), 2010
PMID: 20712055
Biochemical and functional characterization of Helicobacter pylori vesicles.
Olofsson A, Vallström A, Petzold K, Tegtmeyer N, Schleucher J, Carlsson S, Haas R, Backert S, Wai SN, Gröbner G, Arnqvist A., Mol Microbiol 77(6), 2010
PMID: 20659286
Helicobacter pylori exploits cholesterol-rich microdomains for induction of NF-kappaB-dependent responses and peptidoglycan delivery in epithelial cells.
Hutton ML, Kaparakis-Liaskos M, Turner L, Cardona A, Kwok T, Ferrero RL., Infect Immun 78(11), 2010
PMID: 20713621
A global overview of the genetic and functional diversity in the Helicobacter pylori cag pathogenicity island.
Olbermann P, Josenhans C, Moodley Y, Uhr M, Stamer C, Vauterin M, Suerbaum S, Achtman M, Linz B., PLoS Genet 6(8), 2010
PMID: 20808891
The coupling protein Cagbeta and its interaction partner CagZ are required for type IV secretion of the Helicobacter pylori CagA protein.
Jurik A, Hausser E, Kutter S, Pattis I, Prassl S, Weiss E, Fischer W., Infect Immun 78(12), 2010
PMID: 20876293
Integrins as therapeutic targets: lessons and opportunities.
Cox D, Brennan M, Moran N., Nat Rev Drug Discov 9(10), 2010
PMID: 20885411
Mechanisms of disease: Helicobacter pylori virulence factors.
Yamaoka Y., Nat Rev Gastroenterol Hepatol 7(11), 2010
PMID: 20938460
Helicobacter pylori dysregulation of gastric epithelial tight junctions by urease-mediated myosin II activation.
Wroblewski LE, Shen L, Ogden S, Romero-Gallo J, Lapierre LA, Israel DA, Turner JR, Peek RM., Gastroenterology 136(1), 2009
PMID: 18996125
The Helicobacter pylori CagD (HP0545, Cag24) protein is essential for CagA translocation and maximal induction of interleukin-8 secretion.
Cendron L, Couturier M, Angelini A, Barison N, Stein M, Zanotti G., J Mol Biol 386(1), 2009
PMID: 19109970
Helicobacter pylori virulence factors in gastric carcinogenesis.
Wen S, Moss SF., Cancer Lett 282(1), 2009
PMID: 19111390
The type VI secretion system: translocation of effectors and effector-domains.
Pukatzki S, McAuley SB, Miyata ST., Curr Opin Microbiol 12(1), 2009
PMID: 19162533
Expression of Helicobacter pylori CagA domains by library-based construct screening.
Angelini A, Tosi T, Mas P, Acajjaoui S, Zanotti G, Terradot L, Hart DJ., FEBS J 276(3), 2009
PMID: 19143840
NF-kappaB activation by Helicobacter pylori requires Akt-mediated phosphorylation of p65.
Takeshima E, Tomimori K, Kawakami H, Ishikawa C, Sawada S, Tomita M, Senba M, Kinjo F, Mimuro H, Sasakawa C, Fujita J, Mori N., BMC Microbiol 9(), 2009
PMID: 19216748
Helicobacter pylori cag-Pathogenicity island-dependent early immunological response triggers later precancerous gastric changes in Mongolian gerbils.
Wiedemann T, Loell E, Mueller S, Stoeckelhuber M, Stolte M, Haas R, Rieder G., PLoS One 4(3), 2009
PMID: 19270747
Selective upregulation of endothelial E-selectin in response to Helicobacter pylori-induced gastritis.
Svensson H, Hansson M, Kilhamn J, Backert S, Quiding-Järbrink M., Infect Immun 77(7), 2009
PMID: 19414551
Helicobacter pylori in health and disease.
Cover TL, Blaser MJ., Gastroenterology 136(6), 2009
PMID: 19457415
Helicobacter pylori cag pathogenicity island-positive strains induce syndecan-4 expression in gastric epithelial cells.
Magalhães A, Marcos NT, Carvalho AS, David L, Figueiredo C, Bastos J, David G, Reis CA., FEMS Immunol Med Microbiol 56(3), 2009
PMID: 19519784
Bacterial adhesins in host-microbe interactions.
Kline KA, Fälker S, Dahlberg S, Normark S, Henriques-Normark B., Cell Host Microbe 5(6), 2009
PMID: 19527885
Bacterial type IV secretion systems in human disease.
Llosa M, Roy C, Dehio C., Mol Microbiol 73(2), 2009
PMID: 19508287
Proteomic and functional characterization of the outer membrane vesicles from the gastric pathogen Helicobacter pylori.
Mullaney E, Brown PA, Smith SM, Botting CH, Yamaoka YY, Terres AM, Kelleher DP, Windle HJ., Proteomics Clin Appl 3(7), 2009
PMID: 21136987
Comparative genomics of Helicobacter pylori.
Dong QJ, Wang Q, Xin YN, Li N, Xuan SY., World J Gastroenterol 15(32), 2009
PMID: 19705492
Helicobacter pylori and gastric cancer: possible role of microRNAs in this intimate relationship.
Belair C, Darfeuille F, Staedel C., Clin Microbiol Infect 15(9), 2009
PMID: 19702585
The structural biology of type IV secretion systems.
Fronzes R, Christie PJ, Waksman G., Nat Rev Microbiol 7(10), 2009
PMID: 19756009
MUC1 limits Helicobacter pylori infection both by steric hindrance and by acting as a releasable decoy.
Lindén SK, Sheng YH, Every AL, Miles KM, Skoog EC, Florin TH, Sutton P, McGuckin MA., PLoS Pathog 5(10), 2009
PMID: 19816567
Biological diversity of prokaryotic type IV secretion systems.
Alvarez-Martinez CE, Christie PJ., Microbiol Mol Biol Rev 73(4), 2009
PMID: 19946141
A novel diagnostic monoclonal antibody specific for Helicobacter pylori CagA of East Asian type.
Yasuda A, Uchida T, Nguyen LT, Kawazato H, Tanigawa M, Murakami K, Kishida T, Fujioka T, Moriyama M., APMIS 117(12), 2009
PMID: 20078554
Helicobacter pylori type IV secretion apparatus exploits beta1 integrin in a novel RGD-independent manner.
Jiménez-Soto LF, Kutter S, Sewald X, Ertl C, Weiss E, Kapp U, Rohde M, Pirch T, Jung K, Retta SF, Terradot L, Fischer W, Haas R., PLoS Pathog 5(12), 2009
PMID: 19997503
Protein subassemblies of the Helicobacter pylori Cag type IV secretion system revealed by localization and interaction studies.
Kutter S, Buhrdorf R, Haas J, Schneider-Brachert W, Haas R, Fischer W., J Bacteriol 190(6), 2008
PMID: 18178731
Emerging roles of Abl family tyrosine kinases in microbial pathogenesis.
Backert S, Feller SM, Wessler S., Trends Biochem Sci 33(2), 2008
PMID: 18182299
Helicobacter pylori induces an antimicrobial response in rhesus macaques in a cag pathogenicity island-dependent manner.
Hornsby MJ, Huff JL, Kays RJ, Canfield DR, Bevins CL, Solnick JV., Gastroenterology 134(4), 2008
PMID: 18395086
SagA of CagA in Helicobacter pylori pathogenesis.
Hatakeyama M., Curr Opin Microbiol 11(1), 2008
PMID: 18243773
Role of type IV secretion in Helicobacter pylori pathogenesis.
Backert S, Selbach M., Cell Microbiol 10(8), 2008
PMID: 18410539
Cholesterol depletion reduces Helicobacter pylori CagA translocation and CagA-induced responses in AGS cells.
Lai CH, Chang YC, Du SY, Wang HJ, Kuo CH, Fang SH, Fu HW, Lin HH, Chiang AS, Wang WC., Infect Immun 76(7), 2008
PMID: 18443091
Type IV secretion systems: tools of bacterial horizontal gene transfer and virulence.
Juhas M, Crook DW, Hood DW., Cell Microbiol 10(12), 2008
PMID: 18549454
Mechanism for gastric cancer development by Helicobacter pylori infection.
Chiba T, Marusawa H, Seno H, Watanabe N., J Gastroenterol Hepatol 23(8 pt 1), 2008
PMID: 18637055
Regulation of the Helicobacter pylori cellular receptor decay-accelerating factor.
O'Brien DP, Romero-Gallo J, Schneider BG, Chaturvedi R, Delgado A, Harris EJ, Krishna U, Ogden SR, Israel DA, Wilson KT, Peek RM., J Biol Chem 283(35), 2008
PMID: 18579524
Helicobacter pylori produces unique filaments upon host contact in vitro.
Couturier MR, Stein M., Can J Microbiol 54(7), 2008
PMID: 18641700
Molecular mechanisms of epithelial-barrier disruption by Helicobacter pylori.
Wessler S, Backert S., Trends Microbiol 16(8), 2008
PMID: 18619844
Differential phosphoproteome profiling reveals a functional role for VASP in Helicobacter pylori-induced cytoskeleton turnover in gastric epithelial cells.
Knauer O, Binai NA, Carra G, Beckhaus T, Hanschmann KM, Renné T, Backert S, Karas M, Wessler S., Cell Microbiol 10(11), 2008
PMID: 18637808
p120 and Kaiso regulate Helicobacter pylori-induced expression of matrix metalloproteinase-7.
Ogden SR, Wroblewski LE, Weydig C, Romero-Gallo J, O'Brien DP, Israel DA, Krishna US, Fingleton B, Reynolds AB, Wessler S, Peek RM., Mol Biol Cell 19(10), 2008
PMID: 18653469
The role of viral and bacterial pathogens in gastrointestinal cancer.
Selgrad M, Malfertheiner P, Fini L, Goel A, Boland CR, Ricciardiello L., J Cell Physiol 216(2), 2008
PMID: 18338378
Targeting focal adhesions:Helicobacter pylori-host communication in cell migration.
Schneider S, Weydig C, Wessler S., Cell Commun Signal 6(), 2008
PMID: 18684322
VirB2 and VirB5 proteins: specialized adhesins in bacterial type-IV secretion systems?
Backert S, Fronzes R, Waksman G., Trends Microbiol 16(9), 2008
PMID: 18706815
Cooperation of Salmonella pathogenicity islands 1 and 4 is required to breach epithelial barriers.
Gerlach RG, Cláudio N, Rohde M, Jäckel D, Wagner C, Hensel M., Cell Microbiol 10(11), 2008
PMID: 18671822
Toll-like receptor (TLR2, TLR4 and TLR5) gene polymorphisms and Helicobacter pylori infection in children with and without duodenal ulcer.
Moura SB, Almeida LR, Guerra JB, Rocha GA, Camargos Rocha AM, Melo FF, Corrêa-Oliveira R, Bittencourt P, Carvalho SD, Magalhães Queiroz DM., Microbes Infect 10(14-15), 2008
PMID: 18809506
Pathogenesis of Helicobacter pylori infection.
Torres J, Backert S., Helicobacter 13 Suppl 1(), 2008
PMID: 18783516
Microbiology: preparing the shot.
Hauck CR., Nature 449(7164), 2007
PMID: 17943113

24 References

Daten bereitgestellt von Europe PubMed Central.

Integrin-regulated FAK-Src signaling in normal and cancer cells.
Mitra SK, Schlaepfer DD., Curr. Opin. Cell Biol. 18(5), 2006
PMID: 16919435
RGD and other recognition sequences for integrins.
Ruoslahti E., Annu. Rev. Cell Dev. Biol. 12(), 1996
PMID: 8970741

AUTHOR UNKNOWN, 0
Binding and internalization of microorganisms by integrin receptors.
Isberg RR, Tran Van Nhieu G., Trends Microbiol. 2(1), 1994
PMID: 8162429
Bacterial pathogenesis: exploiting cellular adherence.
Boyle EC, Finlay BB., Curr. Opin. Cell Biol. 15(5), 2003
PMID: 14519399

Cascales, Nature Rev. Microbiol. 1(), 2003
Type IV secretion systems and their effectors in bacterial pathogenesis.
Backert S, Meyer TF., Curr. Opin. Microbiol. 9(2), 2006
PMID: 16529981

Amieva, Science 300(), 2004

Peek, Nature Rev. Cancer 2(), 2002
Tyrosine-phosphorylated bacterial proteins: Trojan horses for the host cell.
Covacci A, Rappuoli R., J. Exp. Med. 191(4), 2000
PMID: 10684850
The role of Helicobacter pylori CagA in gastric carcinogenesis.
Hatakeyama M., Int. J. Hematol. 84(4), 2006
PMID: 17118755
Beta 1 integrin-dependent and -independent polymerization of fibronectin.
Wennerberg K, Lohikangas L, Gullberg D, Pfaff M, Johansson S, Fassler R., J. Cell Biol. 132(1-2), 1996
PMID: 8567726
A novel sheathed surface organelle of the Helicobacter pylori cag type IV secretion system.
Rohde M, Puls J, Buhrdorf R, Fischer W, Haas R., Mol. Microbiol. 49(1), 2003
PMID: 12823823
Helicobacter pylori SabA adhesin in persistent infection and chronic inflammation.
Mahdavi J, Sonden B, Hurtig M, Olfat FO, Forsberg L, Roche N, Angstrom J, Larsson T, Teneberg S, Karlsson KA, Altraja S, Wadstrom T, Kersulyte D, Berg DE, Dubois A, Petersson C, Magnusson KE, Norberg T, Lindh F, Lundskog BB, Arnqvist A, Hammarstrom L, Boren T., Science 297(5581), 2002
PMID: 12142529
Functional adaptation of BabA, the H. pylori ABO blood group antigen binding adhesin.
Aspholm-Hurtig M, Dailide G, Lahmann M, Kalia A, Ilver D, Roche N, Vikstrom S, Sjostrom R, Linden S, Backstrom A, Lundberg C, Arnqvist A, Mahdavi J, Nilsson UJ, Velapatino B, Gilman RH, Gerhard M, Alarcon T, Lopez-Brea M, Nakazawa T, Fox JG, Correa P, Dominguez-Bello MG, Perez-Perez GI, Blaser MJ, Normark S, Carlstedt I, Oscarson S, Teneberg S, Berg DE, Boren T., Science 305(5683), 2004
PMID: 15273394
Selective increase of the permeability of polarized epithelial cell monolayers by Helicobacter pylori vacuolating toxin.
Papini E, Satin B, Norais N, de Bernard M, Telford JL, Rappuoli R, Montecucco C., J. Clin. Invest. 102(4), 1998
PMID: 9710450
Specific entry of Helicobacter pylori into cultured gastric epithelial cells via a zipper-like mechanism.
Kwok T, Backert S, Schwarz H, Berger J, Meyer TF., Infect. Immun. 70(4), 2002
PMID: 11895977
Src is the kinase of the Helicobacter pylori CagA protein in vitro and in vivo.
Selbach M, Moese S, Hauck CR, Meyer TF, Backert S., J. Biol. Chem. 277(9), 2002
PMID: 11788577
Integrin alpha5beta1 ligands: biological evaluation and conformational analysis.
Zimmermann D, Guthohrlein EW, Malesevic M, Sewald K, Wobbe L, Heggemann C, Sewald N., Chembiochem 6(2), 2005
PMID: 15645521

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