New chemical derivatives of the natural compound dictyophlebine inhibiting acetyl- and butyrylcholinesterase

Devkota KP, Choudhary MI, Anjum S, Nawaz SA, Lenta BN, Sewald N (2007)
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES 39(3): 1324-1328.

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The acetyl- and butyrylcholinesterase inhibiting natural product dictyophlebine 1 was subjected to different N-alkylation and hydrochlorination reactions by which five new and bioactive chemical derivatives (2-6) with pentyl, pent-4-en-1-yl, hex-5-en-1-yl, 4-chloropentyl and 5-chlorohexyl substituents at the 3-N position were obtained with high yield. The alkylated and chlorinated products 3 - 6 were found to have significantly higher inhibitory potential towards cholinesterase than the parent compound 1.
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Devkota KP, Choudhary MI, Anjum S, Nawaz SA, Lenta BN, Sewald N. New chemical derivatives of the natural compound dictyophlebine inhibiting acetyl- and butyrylcholinesterase. ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES. 2007;39(3):1324-1328.
Devkota, K. P., Choudhary, M. I., Anjum, S., Nawaz, S. A., Lenta, B. N., & Sewald, N. (2007). New chemical derivatives of the natural compound dictyophlebine inhibiting acetyl- and butyrylcholinesterase. ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES, 39(3), 1324-1328.
Devkota, K. P., Choudhary, M. I., Anjum, S., Nawaz, S. A., Lenta, B. N., and Sewald, N. (2007). New chemical derivatives of the natural compound dictyophlebine inhibiting acetyl- and butyrylcholinesterase. ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES 39, 1324-1328.
Devkota, K.P., et al., 2007. New chemical derivatives of the natural compound dictyophlebine inhibiting acetyl- and butyrylcholinesterase. ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES, 39(3), p 1324-1328.
K.P. Devkota, et al., “New chemical derivatives of the natural compound dictyophlebine inhibiting acetyl- and butyrylcholinesterase”, ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES, vol. 39, 2007, pp. 1324-1328.
Devkota, K.P., Choudhary, M.I., Anjum, S., Nawaz, S.A., Lenta, B.N., Sewald, N.: New chemical derivatives of the natural compound dictyophlebine inhibiting acetyl- and butyrylcholinesterase. ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES. 39, 1324-1328 (2007).
Devkota, Krishna P., Choudhary, M. Iqbal, Anjum, Shazia, Nawaz, Sarfaraz A., Lenta, Bruno N., and Sewald, Norbert. “New chemical derivatives of the natural compound dictyophlebine inhibiting acetyl- and butyrylcholinesterase”. ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES 39.3 (2007): 1324-1328.
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