Cholinesterase inhibiting and antiplasmodial steroidal alkaloids from Sarcococca hookeriana

Devkota KP, Lenta BN, Choudhary MI, Naz Q, Fekam FB, Rosenthal PJ, Sewald N (2007)
Chemical & Pharmaceutical Bulletin 55(9): 1397-1401.

Journal Article | Published | English

No fulltext has been uploaded

Author
; ; ; ; ; ;
Abstract
Bioguided phytochemical investigation of Sarcococca hookeriana with respect to the cholinesterase enzyme inhibitory assay yielded two new pregnane-type steriodal alkaloids hookerianamide H (1) and hookerianamide 1 (2), along with three known alkaloids N-a-methylepipachysamine D (3), sarcovagine C (4) and dictyophlebine (5). Their structures were determined with the aid of extensive spectroscopic analysis. All compounds showed good inhibitory activities against the enzymes acetylcholinesterase (IC50 2.9-34.1 mu M) and butyryleholinesterase (IC50 0.3-3.6/mu M). These compounds also showed moderate antiplasmodial activity (IC50 2.4-10.3 mu m) against the Plasmodium falciparum chloroquine resistant W2 strain.
Publishing Year
ISSN
eISSN
PUB-ID

Cite this

Devkota KP, Lenta BN, Choudhary MI, et al. Cholinesterase inhibiting and antiplasmodial steroidal alkaloids from Sarcococca hookeriana. Chemical & Pharmaceutical Bulletin. 2007;55(9):1397-1401.
Devkota, K. P., Lenta, B. N., Choudhary, M. I., Naz, Q., Fekam, F. B., Rosenthal, P. J., & Sewald, N. (2007). Cholinesterase inhibiting and antiplasmodial steroidal alkaloids from Sarcococca hookeriana. Chemical & Pharmaceutical Bulletin, 55(9), 1397-1401.
Devkota, K. P., Lenta, B. N., Choudhary, M. I., Naz, Q., Fekam, F. B., Rosenthal, P. J., and Sewald, N. (2007). Cholinesterase inhibiting and antiplasmodial steroidal alkaloids from Sarcococca hookeriana. Chemical & Pharmaceutical Bulletin 55, 1397-1401.
Devkota, K.P., et al., 2007. Cholinesterase inhibiting and antiplasmodial steroidal alkaloids from Sarcococca hookeriana. Chemical & Pharmaceutical Bulletin, 55(9), p 1397-1401.
K.P. Devkota, et al., “Cholinesterase inhibiting and antiplasmodial steroidal alkaloids from Sarcococca hookeriana”, Chemical & Pharmaceutical Bulletin, vol. 55, 2007, pp. 1397-1401.
Devkota, K.P., Lenta, B.N., Choudhary, M.I., Naz, Q., Fekam, F.B., Rosenthal, P.J., Sewald, N.: Cholinesterase inhibiting and antiplasmodial steroidal alkaloids from Sarcococca hookeriana. Chemical & Pharmaceutical Bulletin. 55, 1397-1401 (2007).
Devkota, Krishna Prasad, Lenta, Bruno Ndjakou, Choudhary, Muhammad Iqbal, Naz, Qamar, Fekam, Fabrice Boyom, Rosenthal, Philip Joseph, and Sewald, Norbert. “Cholinesterase inhibiting and antiplasmodial steroidal alkaloids from Sarcococca hookeriana”. Chemical & Pharmaceutical Bulletin 55.9 (2007): 1397-1401.
This data publication is cited in the following publications:
This publication cites the following data publications:

8 Citations in Europe PMC

Data provided by Europe PubMed Central.

A novel pregnane-type alkaloid from Pachysandra terminalis inhibits methicillin-resistant Staphylococcus aureus in vitro and in vivo.
Zhao H, Wang XY, Li MK, Hou Z, Zhou Y, Chen Z, Meng JR, Luo XX, Tang HF, Xue XY., Phytother Res 29(3), 2015
PMID: 25414071
Natural AChE Inhibitors from Plants and their Contribution to Alzheimer's Disease Therapy.
Murray AP, Faraoni MB, Castro MJ, Alza NP, Cavallaro V., Curr Neuropharmacol 11(4), 2013
PMID: 24381530
Alkaloids as a source of potential anticholinesterase inhibitors for the treatment of Alzheimer's disease.
Konrath EL, Passos Cdos S, Klein LC Jr, Henriques AT., J. Pharm. Pharmacol. 65(12), 2013
PMID: 24236981
N-substituted piperazinopyridylsteroid derivatives as abiraterone analogues inhibit growth and induce pro-apoptosis in human hormone-independent prostate cancer cell lines.
Brossard D, Zhang Y, Haider SM, Sgobba M, Khalid M, Legay R, Duterque-Coquillaud M, Galera P, Rault S, Dallemagne P, Moslemi S, El Kihel L., Chem Biol Drug Des 82(5), 2013
PMID: 23906044
Anti-malarial property of steroidal alkaloid conessine isolated from the bark of Holarrhena antidysenterica.
Dua VK, Verma G, Singh B, Rajan A, Bagai U, Agarwal DD, Gupta NC, Kumar S, Rastogi A., Malar. J. 12(), 2013
PMID: 23758861
Pregnane alkaloids from Sarcococca hookeriana var. digyna.
Zhang PZ, Wang F, Yang LJ, Zhang GL., Fitoterapia 89(), 2013
PMID: 23651560
Antimalarial compounds isolated from plants used in traditional medicine.
Bero J, Frederich M, Quetin-Leclercq J., J. Pharm. Pharmacol. 61(11), 2009
PMID: 19903367
Terpenoid alkaloids of the Buxaceae family with potential biological importance.
Devkota KP, Lenta BN, Fokou PA, Sewald N., Nat Prod Rep 25(3), 2008
PMID: 18497899

29 References

Data provided by Europe PubMed Central.


AUTHOR UNKNOWN, 0
A new and rapid colorimetric determination of acetylcholinesterase activity.
ELLMAN GL, COURTNEY KD, ANDRES V Jr, FEATHER-STONE RM., Biochem. Pharmacol. 7(), 1961
PMID: 13726518
Comparison of efficacies of cysteine protease inhibitors against five strains of Plasmodium falciparum.
Singh A, Rosenthal PJ., Antimicrob. Agents Chemother. 45(3), 2001
PMID: 11181388

AUTHOR UNKNOWN, 0

Export

0 Marked Publications

Open Data PUB

Web of Science

View record in Web of Science®

Sources

PMID: 17827771
PubMed | Europe PMC

Search this title in

Google Scholar