Leishmanicidal and cholinesterase inhibiting activities of phenolic compounds from Allanblackia monticola and Symphonia globulifera

Lenta BN, Vonthron-Senecheau C, Weniger B, Devkota KP, Ngoupayo J, Kaiser M, Naz Q, Choudhary MI, Tsamo E, Sewald N (2007)
MOLECULES 12(8): 1548-1557.

Journal Article | Published | English

No fulltext has been uploaded

Author
; ; ; ; ; ; ; ; ;
Abstract
In a preliminary antiprotozoal screening of several Clusiaceae species, the methanolic extracts of Allanblackia monticola and Symphonia globulifera showed high in vitro leishmanicidal activity. Further bioguided phytochemical investigation led to the isolation of four benzophenones: guttiferone A (1), garcinol (2), cambogin (3) and guttiferone F (4), along with three xanthones: allanxanthone A (5), xanthone V-1 (6) and globulixanthone C (7) as active constituents. Compounds 1 and 6 were isolated from S. globulifera leaves, while compounds 2-5 were obtained from A. monticola fruits. Guttiferone A (1) and F (4) showed particulary strong leishmanicidal activity in vitro, with IC50 values (0.2 mu M and 0.16 mu M, respectively) comparable to that of the reference compound, miltefosine (0.46 mu M). Although the leishmanicidal activity is promising, the cytotoxicity profile of these compounds prevent at this state further in vivo biological evaluation. In addition, all the isolated compounds were tested in vitro for their anticholinesterase properties. The four benzophenones showed potent anticholinesterase properties towards acetylcholinesterase (ACNE) and butylcholinesterase (AChE). For ACNE, the IC50 value (0.66 mu M) of garcinol (2) was almost equal to that of the reference compound galanthamine (0.50 mu M). Furthermore, guttiferone A (1) and guttiferone F (4) (IC50 = 2.77 and 3.50 mu M, respectively) were more active than galanthamine (ICSO = 8.5) against BChE.
Publishing Year
ISSN
PUB-ID

Cite this

Lenta BN, Vonthron-Senecheau C, Weniger B, et al. Leishmanicidal and cholinesterase inhibiting activities of phenolic compounds from Allanblackia monticola and Symphonia globulifera. MOLECULES. 2007;12(8):1548-1557.
Lenta, B. N., Vonthron-Senecheau, C., Weniger, B., Devkota, K. P., Ngoupayo, J., Kaiser, M., Naz, Q., et al. (2007). Leishmanicidal and cholinesterase inhibiting activities of phenolic compounds from Allanblackia monticola and Symphonia globulifera. MOLECULES, 12(8), 1548-1557.
Lenta, B. N., Vonthron-Senecheau, C., Weniger, B., Devkota, K. P., Ngoupayo, J., Kaiser, M., Naz, Q., Choudhary, M. I., Tsamo, E., and Sewald, N. (2007). Leishmanicidal and cholinesterase inhibiting activities of phenolic compounds from Allanblackia monticola and Symphonia globulifera. MOLECULES 12, 1548-1557.
Lenta, B.N., et al., 2007. Leishmanicidal and cholinesterase inhibiting activities of phenolic compounds from Allanblackia monticola and Symphonia globulifera. MOLECULES, 12(8), p 1548-1557.
B.N. Lenta, et al., “Leishmanicidal and cholinesterase inhibiting activities of phenolic compounds from Allanblackia monticola and Symphonia globulifera”, MOLECULES, vol. 12, 2007, pp. 1548-1557.
Lenta, B.N., Vonthron-Senecheau, C., Weniger, B., Devkota, K.P., Ngoupayo, J., Kaiser, M., Naz, Q., Choudhary, M.I., Tsamo, E., Sewald, N.: Leishmanicidal and cholinesterase inhibiting activities of phenolic compounds from Allanblackia monticola and Symphonia globulifera. MOLECULES. 12, 1548-1557 (2007).
Lenta, Bruno Ndjakou, Vonthron-Senecheau, Catherine, Weniger, Bernard, Devkota, Krishna Prasad, Ngoupayo, Joseph, Kaiser, Marcel, Naz, Qamar, Choudhary, Muhammad Iqbal, Tsamo, Etienne, and Sewald, Norbert. “Leishmanicidal and cholinesterase inhibiting activities of phenolic compounds from Allanblackia monticola and Symphonia globulifera”. MOLECULES 12.8 (2007): 1548-1557.
This data publication is cited in the following publications:
This publication cites the following data publications:

19 Citations in Europe PMC

Data provided by Europe PubMed Central.

Antiplasmodial activity of some phenolic compounds from Cameroonians Allanblackia.
Azebaze AG, Teinkela JE, Nguemfo EL, Valentin A, Dongmo AB, Vardamides JC., Afr Health Sci 15(3), 2015
PMID: 26957972
Role of mitochondria in the leishmanicidal effects and toxicity of acyl phloroglucinol derivatives: nemorosone and guttiferone A.
Monzote L, Lackova A, Staniek K, Cuesta-Rubio O, Gille L., Parasitology 142(9), 2015
PMID: 26027642
Comparative LC-MS-based metabolite profiling of the ancient tropical rainforest tree Symphonia globulifera.
Cottet K, Genta-Jouve G, Fromentin Y, Odonne G, Duplais C, Laprevote O, Michel S, Lallemand MC., Phytochemistry 108(), 2014
PMID: 25301665
Nature as a source of metabolites with cholinesterase-inhibitory activity: an approach to Alzheimer's disease treatment.
Pinho BR, Ferreres F, Valentao P, Andrade PB., J. Pharm. Pharmacol. 65(12), 2013
PMID: 24236980
Non-toxic melanin production inhibitors from Garcinia livingstonei (Clusiaceae).
Mulholland DA, Mwangi EM, Dlova NC, Plant N, Crouch NR, Coombes PH., J Ethnopharmacol 149(2), 2013
PMID: 23891889
Synthesis of novel guttiferone A derivatives: in-vitro evaluation toward Plasmodium falciparum, Trypanosoma brucei and Leishmania donovani.
Fromentin Y, Gaboriaud-Kolar N, Lenta BN, Wansi JD, Buisson D, Mouray E, Grellier P, Loiseau PM, Lallemand MC, Michel S., Eur J Med Chem 65(), 2013
PMID: 23727538
Cytotoxicity and modes of action of four naturally occuring benzophenones: 2,2',5,6'-tetrahydroxybenzophenone, guttiferone E, isogarcinol and isoxanthochymol.
Kuete V, Tchakam PD, Wiench B, Ngameni B, Wabo HK, Tala MF, Moungang ML, Ngadjui BT, Murayama T, Efferth T., Phytomedicine 20(6), 2013
PMID: 23507522
Cytotoxic and leishmanicidal properties of garcinielliptone FC, a prenylated benzophenone from Platonia insignis.
Costa Junior JS, de Almeida AA, de Barros Falcao Ferraz A, Rossatto RR, Silva TG, Silva PB, Militao GC, das Gracas Lopes Cito AM, Santana LC, de Amorim Carvalho FA, Freitas RM., Nat. Prod. Res. 27(4-5), 2013
PMID: 22708546
Isolation and evaluation of the antioxidant activity of phenolic constituents of the Garcinia brasiliensis epicarp
Gontijo VS, de Souza TC, Rosa IA, Soares MG, da Silva MA, Vilegas W, Viegas CJ, dos Santos MH., Food Chem 132(3), 2012
PMID: IND44653089
The chemistry and medicinal uses of the underutilized Indian fruit tree Garcinia indica Choisy (kokum): A review
Baliga MS, Bhat HP, Pai RJ, Boloor R, Palatty PL., Food Res. Int. 44(7), 2011
PMID: IND44612687
Evaluation of possible antioxidant and anticonvulsant effects of the ethyl acetate fraction from Platonia insignis Mart. (Bacuri) on epilepsy models.
Junior JS, de Almeida AA, Tome Ada R, Cito AM, Saffi J, de Freitas RM., Epilepsy Behav 22(4), 2011
PMID: 22056341
Anticancer activities of six selected natural compounds of some Cameroonian medicinal plants.
Kuete V, Wabo HK, Eyong KO, Feussi MT, Wiench B, Krusche B, Tane P, Folefoc GN, Efferth T., PLoS ONE 6(8), 2011
PMID: 21886765
Antimicrobial evaluation of the polyisoprenylated benzophenones nemorosone and guttiferone A.
Monzote L, Cuesta-Rubio O, Matheeussen A, Van Assche T, Maes L, Cos P., Phytother Res 25(3), 2011
PMID: 21259352
An antiproliferative xanthone of Symphonia pauciflora from the Madagascar rainforest.
Pana E, Cao S, Brodie PJ, Miller JS, Rakotodrajaona R, Ratovoson F, Birkinshaw C, Andriantsiferana R, Rasamison VE, Kingston DG., Nat Prod Commun 5(5), 2010
PMID: 20521541

Export

0 Marked Publications

Open Data PUB

Web of Science

View record in Web of Science®

Sources

PMID: 17960072
PubMed | Europe PMC

Search this title in

Google Scholar