Complete genome sequence of the myxobacterium Sorangium cellulosum

Schneiker-Bekel S, Perlova O, Kaiser O, Gerth K, Alici A, Altmeyer MO, Bartels D, Bekel T, Beyer S, Bode E, Bode HB, et al. (2007)
Nature Biotechnology 25(11): 1281-1289.

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The genus Sorangium synthesizes approximately half of the secondary metabolites isolated from myxobacteria, including the anti-cancer metabolite epothilone. We report the complete genome sequence of the model Sorangium strain S. cellulosum So ce56, which produces several natural products and has morphological and physiological properties typical of the genus. The circular genome, comprising 13,033,779 base pairs, is the largest bacterial genome sequenced to date. No global synteny with the genome of Myxococcus xanthus is apparent, revealing an unanticipated level of divergence between these myxobacteria. A large percentage of the genome is devoted to regulation, particularly post-translational phosphorylation, which probably supports the strain's complex, social lifestyle. This regulatory network includes the highest number of eukaryotic protein kinase-like kinases discovered in any organism. Seventeen secondary metabolite loci are encoded in the genome, as well as many enzymes with potential utility in industry.
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Schneiker-Bekel S, Perlova O, Kaiser O, et al. Complete genome sequence of the myxobacterium Sorangium cellulosum. Nature Biotechnology. 2007;25(11):1281-1289.
Schneiker-Bekel, S., Perlova, O., Kaiser, O., Gerth, K., Alici, A., Altmeyer, M. O., Bartels, D., et al. (2007). Complete genome sequence of the myxobacterium Sorangium cellulosum. Nature Biotechnology, 25(11), 1281-1289. doi:10.1038/nbt1354
Schneiker-Bekel, S., Perlova, O., Kaiser, O., Gerth, K., Alici, A., Altmeyer, M. O., Bartels, D., Bekel, T., Beyer, S., Bode, E., et al. (2007). Complete genome sequence of the myxobacterium Sorangium cellulosum. Nature Biotechnology 25, 1281-1289.
Schneiker-Bekel, S., et al., 2007. Complete genome sequence of the myxobacterium Sorangium cellulosum. Nature Biotechnology, 25(11), p 1281-1289.
S. Schneiker-Bekel, et al., “Complete genome sequence of the myxobacterium Sorangium cellulosum”, Nature Biotechnology, vol. 25, 2007, pp. 1281-1289.
Schneiker-Bekel, S., Perlova, O., Kaiser, O., Gerth, K., Alici, A., Altmeyer, M.O., Bartels, D., Bekel, T., Beyer, S., Bode, E., Bode, H.B., Bolten, C.J., Choudhuri, J.V., Doss, S., Elnakady, Y.A., Frank, B., Gaigalat, L., Goesmann, A., Groeger, C., Gross, F., Jelsbak, L., Jelsbak, L., Kalinowski, J., Kegler, C., Knauber, T., Konietzny, S., Kopp, M., Krause, L., Krug, D., Linke, B., Mahmud, T., Martinez-Arias, R., McHardy, A.C., Merai, M., Meyer, F., Mormann, S., Munoz-Dorado, J., Perez, J., Pradella, S., Rachid, S., Raddatz, G., Rosenau, F., Rückert, C., Sasse, F., Scharfe, M., Schuster, S.C., Suen, G., Treuner-Lange, A., Velicer, G.J., Vorhölter, F.-J., Weissman, K.J., Welch, R.D., Wenzel, S.C., Whitworth, D.E., Wilhelm, S., Wittmann, C., Bloecker, H., Pühler, A., Mueller, R.: Complete genome sequence of the myxobacterium Sorangium cellulosum. Nature Biotechnology. 25, 1281-1289 (2007).
Schneiker-Bekel, Susanne, Perlova, Olena, Kaiser, Olaf, Gerth, Klaus, Alici, Aysel, Altmeyer, Matthias O., Bartels, Daniela, Bekel, Thomas, Beyer, Stefan, Bode, Edna, Bode, Helge B., Bolten, Christoph J., Choudhuri, Jomuna V., Doss, Sabrina, Elnakady, Yasser A., Frank, Bettina, Gaigalat, Lars, Goesmann, Alexander, Groeger, Carolin, Gross, Frank, Jelsbak, Lars, Jelsbak, Lotte, Kalinowski, Jörn, Kegler, Carsten, Knauber, Tina, Konietzny, Sebastian, Kopp, Maren, Krause, Lutz, Krug, Daniel, Linke, Burkhard, Mahmud, Taifo, Martinez-Arias, Rosa, McHardy, Alice C., Merai, Michelle, Meyer, Folker, Mormann, Sascha, Munoz-Dorado, Jose, Perez, Juana, Pradella, Silke, Rachid, Shwan, Raddatz, Guenter, Rosenau, Frank, Rückert, Christian, Sasse, Florenz, Scharfe, Maren, Schuster, Stephan C., Suen, Garret, Treuner-Lange, Anke, Velicer, Gregory J., Vorhölter, Frank-Jörg, Weissman, Kira J., Welch, Roy D., Wenzel, Silke C., Whitworth, David E., Wilhelm, Susanne, Wittmann, Christoph, Bloecker, Helmut, Pühler, Alfred, and Mueller, Rolf. “Complete genome sequence of the myxobacterium Sorangium cellulosum”. Nature Biotechnology 25.11 (2007): 1281-1289.
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Data provided by Europe PubMed Central.

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Park SR, Tripathi A, Wu J, Schultz PJ, Yim I, McQuade TJ, Yu F, Arevang CJ, Mensah AY, Tamayo-Castillo G, Xi C, Sherman DH., Nat Commun 7(), 2016
PMID: 26880271
Highly Efficient CYP167A1 (EpoK) dependent Epothilone B Formation and Production of 7-Ketone Epothilone D as a New Epothilone Derivative.
Kern F, Dier TK, Khatri Y, Ewen KM, Jacquot JP, Volmer DA, Bernhardt R., Sci Rep 5(), 2015
PMID: 26445909
Multiple nucleophilic elbows leading to multiple active sites in a single module esterase from Sorangium cellulosum.
Udatha DB, Madsen KM, Panagiotou G, Olsson L., J. Struct. Biol. 190(3), 2015
PMID: 25907516
Antimalarial activity of the myxobacterial macrolide chlorotonil a.
Held J, Gebru T, Kalesse M, Jansen R, Gerth K, Muller R, Mordmuller B., Antimicrob. Agents Chemother. 58(11), 2014
PMID: 25114138
A highly unusual polyketide synthase directs dawenol polyene biosynthesis in Stigmatella aurantiaca.
Oßwald C, Zaburannyi N, Burgard C, Hoffmann T, Wenzel SC, Muller R., J. Biotechnol. 191(), 2014
PMID: 25102237
A recent evolutionary origin of a bacterial small RNA that controls multicellular fruiting body development.
Chen IC, Griesenauer B, Yu YT, Velicer GJ., Mol. Phylogenet. Evol. 73(), 2014
PMID: 24418530
Impact of water quality on the bacterial populations and off-flavours in recirculating aquaculture systems.
Auffret M, Yergeau E, Pilote A, Proulx E, Proulx D, Greer CW, Vandenberg G, Villemur R., FEMS Microbiol. Ecol. 84(2), 2013
PMID: 23228051
Sulfangolids, macrolide sulfate esters from Sorangium cellulosum.
Zander W, Irschik H, Augustiniak H, Herrmann M, Jansen R, Steinmetz H, Gerth K, Kessler W, Kalesse M, Hofle G, Muller R., Chemistry 18(20), 2012
PMID: 22488821
Xenobiotic efflux in bacteria and fungi: a genomics update.
Barabote RD, Thekkiniath J, Strauss RE, Vediyappan G, Fralick JA, San Francisco MJ., Adv. Enzymol. Relat. Areas Mol. Biol. 77(), 2011
PMID: 21692371
Bacterial NO Synthases.
Filippovich SIu., Biochemistry Mosc. 75(10), 2010
PMID: 21166639
NtcA: a negative regulator of secondary metabolite biosynthesis in Sorangium cellulosum.
Rachid S, Gerth K, Muller R., J. Biotechnol. 140(1-2), 2009
PMID: 19041909

45 References

Data provided by Europe PubMed Central.

Complete genome sequence of the industrial bacterium Bacillus licheniformis and comparisons with closely related Bacillus species.
Rey MW, Ramaiya P, Nelson BA, Brody-Karpin SD, Zaretsky EJ, Tang M, Lopez de Leon A, Xiang H, Gusti V, Clausen IG, Olsen PB, Rasmussen MD, Andersen JT, Jorgensen PL, Larsen TS, Sorokin A, Bolotin A, Lapidus A, Galleron N, Ehrlich SD, Berka RM., Genome Biol. 5(10), 2004
PMID: 15461803
Comparative analysis of four Campylobacterales.
Eppinger M, Baar C, Raddatz G, Huson DH, Schuster SC., Nat. Rev. Microbiol. 2(11), 2004
PMID: 15494744
BACCardI--a tool for the validation of genomic assemblies, assisting genome finishing and intergenome comparison.
Bartels D, Kespohl S, Albaum S, Druke T, Goesmann A, Herold J, Kaiser O, Puhler A, Pfeiffer F, Raddatz G, Stoye J, Meyer F, Schuster SC., Bioinformatics 21(7), 2005
PMID: 15514001
Novel insights into siderophore formation in myxobacteria.
Gaitatzis N, Kunze B, Muller R., Chembiochem 6(2), 2005
PMID: 15678426
Functional genome annotation through phylogenomic mapping.
Srinivasan BS, Caberoy NB, Suen G, Taylor RG, Shah R, Tengra F, Goldman BS, Garza AG, Welch RD., Nat. Biotechnol. 23(6), 2005
PMID: 15940241
A novel type of geosmin biosynthesis in myxobacteria.
Dickschat JS, Bode HB, Mahmud T, Muller R, Schulz S., J. Org. Chem. 70(13), 2005
PMID: 15960521
Protein length in eukaryotic and prokaryotic proteomes.
Brocchieri L, Karlin S., Nucleic Acids Res. 33(10), 2005
PMID: 15951512
Bacterial type III polyketide synthases: phylogenetic analysis and potential for the production of novel secondary metabolites by heterologous expression in pseudomonads.
Gross F, Luniak N, Perlova O, Gaitatzis N, Jenke-Kodama H, Gerth K, Gottschalk D, Dittmann E, Muller R., Arch. Microbiol. 185(1), 2006
PMID: 16395556
Evolution of sensory complexity recorded in a myxobacterial genome.
Goldman BS, Nierman WC, Kaiser D, Slater SC, Durkin AS, Eisen JA, Eisen J, Ronning CM, Barbazuk WB, Blanchard M, Field C, Halling C, Hinkle G, Iartchuk O, Kim HS, Mackenzie C, Madupu R, Miller N, Shvartsbeyn A, Sullivan SA, Vaudin M, Wiegand R, Kaplan HB., Proc. Natl. Acad. Sci. U.S.A. 103(41), 2006
PMID: 17015832
Structural and functional diversity of the microbial kinome.
Kannan N, Taylor SS, Zhai Y, Venter JC, Manning G., PLoS Biol. 5(3), 2007
PMID: 17355172
Etnangien, a macrolide-polyene antibiotic from Sorangium cellulosum that inhibits nucleic acid polymerases.
Irschik H, Schummer D, Hofle G, Reichenbach H, Steinmetz H, Jansen R., J. Nat. Prod. 70(6), 2007
PMID: 17547459


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