Neuroproteomics in stem cell differentiation

Beyer S, Mix E, Hoffrogge R, Luenser K, Voelker U, Rolfs A (2007)
PROTEOMICS CLINICAL APPLICATIONS 1(11): 1513-1523.

Download
Es wurde kein Volltext hochgeladen. Nur Publikationsnachweis!
Zeitschriftenaufsatz | Veröffentlicht | Englisch
Autor
; ; ; ; ;
Abstract / Bemerkung
The term "proteome" is used to describe the entire complement of proteins in a given organism or in a system at a given time. Proteome analysis in neuroscience, also called "neuroproteomics" or "neuromics" is in its initial stage, and shows a deficit of studies in the context of brain development. It is the main objective of this review to illustrate the potential of neuroproteomics as a tool to unravel the differentiation of neural stem or progenitor cells to terminally differentiated neurons. Experimental results regarding the rat striatal progenitor model cell line ST14A are presented to illustrate the large rearrangements of the proteome during the differentiation process of neural progenitor cells and their modification by neurotrophic factors like the glial cell line-derived neurotrophic factor (GDNF). Thereby native stem cells and cells transfected with GDNF gene were investigated at the proliferative state and at seven time points up to 72 h after induction of differentiation. In addition, the immortalized human fetal midbrain stem cell line ReNcell VM was analyzed in order to detect stem cell differentiation associated changes of the protein profile. This review gives also an outlook on technical improvements and perspectives of application of neural stem cell proteomics.
Erscheinungsjahr
Zeitschriftentitel
PROTEOMICS CLINICAL APPLICATIONS
Band
1
Zeitschriftennummer
11
Seite
1513-1523
ISSN
eISSN
PUB-ID

Zitieren

Beyer S, Mix E, Hoffrogge R, Luenser K, Voelker U, Rolfs A. Neuroproteomics in stem cell differentiation. PROTEOMICS CLINICAL APPLICATIONS. 2007;1(11):1513-1523.
Beyer, S., Mix, E., Hoffrogge, R., Luenser, K., Voelker, U., & Rolfs, A. (2007). Neuroproteomics in stem cell differentiation. PROTEOMICS CLINICAL APPLICATIONS, 1(11), 1513-1523. doi:10.1002/prca.200700324
Beyer, S., Mix, E., Hoffrogge, R., Luenser, K., Voelker, U., and Rolfs, A. (2007). Neuroproteomics in stem cell differentiation. PROTEOMICS CLINICAL APPLICATIONS 1, 1513-1523.
Beyer, S., et al., 2007. Neuroproteomics in stem cell differentiation. PROTEOMICS CLINICAL APPLICATIONS, 1(11), p 1513-1523.
S. Beyer, et al., “Neuroproteomics in stem cell differentiation”, PROTEOMICS CLINICAL APPLICATIONS, vol. 1, 2007, pp. 1513-1523.
Beyer, S., Mix, E., Hoffrogge, R., Luenser, K., Voelker, U., Rolfs, A.: Neuroproteomics in stem cell differentiation. PROTEOMICS CLINICAL APPLICATIONS. 1, 1513-1523 (2007).
Beyer, Susanne, Mix, Eilhard, Hoffrogge, Raimund, Luenser, Katja, Voelker, Uwe, and Rolfs, Arndt. “Neuroproteomics in stem cell differentiation”. PROTEOMICS CLINICAL APPLICATIONS 1.11 (2007): 1513-1523.

0 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Export

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®

Quellen

PMID: 21136647
PubMed | Europe PMC

Suchen in

Google Scholar