Density of dopaminergic fibres in the prefrontal cortex of gerbils is sensitive to aging

Brummelte S, Teuchert-Noodt G (2007)
Behavioral and Brain Functions 3(1): 14.

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Mesencephalic dopamine (DA) projections are essential for cognitive and behavioral functions and believed to play a critical role during development and aging. The dopaminergic afferents of the rodent prefrontal cortex (PFC) show an extremely prolonged maturation which is very sensitive to epigenetic challenges. However, less is known about the long-term maturation and aging of these DA axons. Therefore, immunohistochemically stained DA fibres were quantitatively examined in the PFC of the Mongolian gerbil (Meriones unguiculatus) ranging from 6 to 24 months of age. Results show a decrease in DA fibre densities in the superficial layers of the PFC in 24 month old animals compared to 6 and 12 months.
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Brummelte S, Teuchert-Noodt G. Density of dopaminergic fibres in the prefrontal cortex of gerbils is sensitive to aging. Behavioral and Brain Functions. 2007;3(1): 14.
Brummelte, S., & Teuchert-Noodt, G. (2007). Density of dopaminergic fibres in the prefrontal cortex of gerbils is sensitive to aging. Behavioral and Brain Functions, 3(1): 14.
Brummelte, S., and Teuchert-Noodt, G. (2007). Density of dopaminergic fibres in the prefrontal cortex of gerbils is sensitive to aging. Behavioral and Brain Functions 3:14.
Brummelte, S., & Teuchert-Noodt, G., 2007. Density of dopaminergic fibres in the prefrontal cortex of gerbils is sensitive to aging. Behavioral and Brain Functions, 3(1): 14.
S. Brummelte and G. Teuchert-Noodt, “Density of dopaminergic fibres in the prefrontal cortex of gerbils is sensitive to aging”, Behavioral and Brain Functions, vol. 3, 2007, : 14.
Brummelte, S., Teuchert-Noodt, G.: Density of dopaminergic fibres in the prefrontal cortex of gerbils is sensitive to aging. Behavioral and Brain Functions. 3, : 14 (2007).
Brummelte, Susanne, and Teuchert-Noodt, Gertraud. “Density of dopaminergic fibres in the prefrontal cortex of gerbils is sensitive to aging”. Behavioral and Brain Functions 3.1 (2007): 14.
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22 References

Data provided by Europe PubMed Central.

Cellular and molecular mechanisms of impaired dopaminergic function during aging.
Roth GS, Joseph JA., Ann. N. Y. Acad. Sci. 719(), 1994
PMID: 8010587
Age-related decline of dopamine synthesis in the living human brain measured by positron emission tomography with L-[beta-11C]DOPA.
Ota M, Yasuno F, Ito H, Seki C, Nozaki S, Asada T, Suhara T., Life Sci. 79(8), 2006
PMID: 16580023
Age-related reduction of extrastriatal dopamine D2 receptor measured by PET.
Inoue M, Suhara T, Sudo Y, Okubo Y, Yasuno F, Kishimoto T, Yoshikawa K, Tanada S., Life Sci. 69(9), 2001
PMID: 11508650
Age-related changes in human D1 dopamine receptors measured by positron emission tomography.
Suhara T, Fukuda H, Inoue O, Itoh T, Suzuki K, Yamasaki T, Tateno Y., Psychopharmacology (Berl.) 103(1), 1991
PMID: 1826059
Age-related dopamine D2/D3 receptor loss in extrastriatal regions of the human brain.
Kaasinen V, Vilkman H, Hietala J, Nagren K, Helenius H, Olsson H, Farde L, Rinne J., Neurobiol. Aging 21(5), 2000
PMID: 11016537
Age-related changes in multiple neurotransmitter systems in the monkey brain.
Wenk GL, Pierce DJ, Struble RG, Price DL, Cork LC., Neurobiol. Aging 10(1), 1989
PMID: 2569169
Ontogeny of the dopamine innervation in the nucleus accumbens of gerbils.
Lesting J, Neddens J, Teuchert-Noodt G., Brain Res. 1066(1-2), 2005
PMID: 16343448
Prefrontal executive and cognitive functions in rodents: neural and neurochemical substrates.
Dalley JW, Cardinal RN, Robbins TW., Neurosci Biobehav Rev 28(7), 2004
PMID: 15555683
Dopamine release during stress in the prefrontal cortex of the rat decreases with age.
Del Arco A, Segovia G, Mora F., Neuroreport 12(18), 2001
PMID: 11742231
Effect of age and gender on dopamine transporter imaging with [123I]FP-CIT SPET in healthy volunteers.
Lavalaye J, Booij J, Reneman L, Habraken JB, van Royen EA., Eur J Nucl Med 27(7), 2000
PMID: 10952500
Development of the dopaminergic innervation in the prefrontal cortex of the rat.
Kalsbeek A, Voorn P, Buijs RM, Pool CW, Uylings HB., J. Comp. Neurol. 269(1), 1988
PMID: 3361004
Long-term effects of a single adult methamphetamine challenge: minor impact on dopamine fibre density in limbic brain areas of gerbils.
Brummelte S, Grund T, Czok A, Teuchert-Noodt G, Neddens J., Behav Brain Funct 2(), 2006
PMID: 16569246
Age-dependent changes in noradrenergic innervations of the frontal cortex in F344 rats.
Ishida Y, Shirokawa T, Miyaishi O, Komatsu Y, Isobe K., Neurobiol. Aging 22(2), 2001
PMID: 11182478

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