Decision-making and neuroendocrine responses in pathological gamblers

Labudda K, Wolf OT, Markowitsch HJ, Brand M (2007)
PSYCHIATRY RESEARCH 153(3): 233-243.

Journal Article | Published | English

No fulltext has been uploaded

Abstract
Recent neuropsychological research indicates that patients with pathological gambling (PG) exhibit deficits in laboratory tasks of decision-making which are suggested to be associated with neurochemical alterations within the prefrontal cortex. Some studies also revealed that hypothalamic-pituitary-adrenal axis activity in gamblers is altered. To date, very little is known about the relationship between decision-making and neuroendocrine parameters. Therefore, we examined patients with PG (n = 22) and healthy comparison subjects (n = 19) with a laboratory task of decision-making (Game of Dice Task) and sampled salivary cortisol and alpha-amylase (sAA) concentrations before and in the course of task performance. Results showed that the PG patients' neuroendocrine responses were comparable to those of the healthy subjects, even though the patients had severe decision-making deficits. Within both groups, there were no changes in cortisol and sAA responses. However, correlations and a subgroup analysis for sAA revealed that only those patients who showed less disadvantageous decision-making patterns had an increase of sAA during the task. Accordingly, the increase of sAA - as an indirect marker of sympathetic nervous system activity - in those patients with less severe decision-making deficits could reflect the use of somatic markers biasing the decision-making process. (C) 2007 Elsevier Ireland Ltd. All rights reserved.
Publishing Year
ISSN
PUB-ID

Cite this

Labudda K, Wolf OT, Markowitsch HJ, Brand M. Decision-making and neuroendocrine responses in pathological gamblers. PSYCHIATRY RESEARCH. 2007;153(3):233-243.
Labudda, K., Wolf, O. T., Markowitsch, H. J., & Brand, M. (2007). Decision-making and neuroendocrine responses in pathological gamblers. PSYCHIATRY RESEARCH, 153(3), 233-243.
Labudda, K., Wolf, O. T., Markowitsch, H. J., and Brand, M. (2007). Decision-making and neuroendocrine responses in pathological gamblers. PSYCHIATRY RESEARCH 153, 233-243.
Labudda, K., et al., 2007. Decision-making and neuroendocrine responses in pathological gamblers. PSYCHIATRY RESEARCH, 153(3), p 233-243.
K. Labudda, et al., “Decision-making and neuroendocrine responses in pathological gamblers”, PSYCHIATRY RESEARCH, vol. 153, 2007, pp. 233-243.
Labudda, K., Wolf, O.T., Markowitsch, H.J., Brand, M.: Decision-making and neuroendocrine responses in pathological gamblers. PSYCHIATRY RESEARCH. 153, 233-243 (2007).
Labudda, Kirsten, Wolf, Oliver T., Markowitsch, Hans J., and Brand, Matthias. “Decision-making and neuroendocrine responses in pathological gamblers”. PSYCHIATRY RESEARCH 153.3 (2007): 233-243.
This data publication is cited in the following publications:
This publication cites the following data publications:

17 Citations in Europe PMC

Data provided by Europe PubMed Central.

To play or not to play: a personal dilemma in pathological gambling.
Giorgetta C, Grecucci A, Rattin A, Guerreschi C, Sanfey AG, Bonini N., Psychiatry Res 219(3), 2014
PMID: 25024055
Getting a grip on problem gambling: what can neuroscience tell us?
Goudriaan AE, Yucel M, van Holst RJ., Front Behav Neurosci 8(), 2014
PMID: 24904328
Strategic and non-strategic problem gamblers differ on decision-making under risk and ambiguity.
Lorains FK, Dowling NA, Enticott PG, Bradshaw JL, Trueblood JS, Stout JC., Addiction 109(7), 2014
PMID: 24450756
Dysfunctional decision-making in pathological gambling: pattern specificity and the role of impulsivity.
Kraplin A, Dshemuchadse M, Behrendt S, Scherbaum S, Goschke T, Buhringer G., Psychiatry Res 215(3), 2014
PMID: 24434041
In vivo evidence for greater amphetamine-induced dopamine release in pathological gambling: a positron emission tomography study with [(11)C]-(+)-PHNO.
Boileau I, Payer D, Chugani B, Lobo DS, Houle S, Wilson AA, Warsh J, Kish SJ, Zack M., Mol. Psychiatry 19(12), 2014
PMID: 24322203
Neural mechanisms mediating association of sympathetic activity and exploration in decision-making.
Ohira H, Matsunaga M, Murakami H, Osumi T, Fukuyama S, Shinoda J, Yamada J., Neuroscience 246(), 2013
PMID: 23643977
Shifted risk preferences in pathological gambling.
Ligneul R, Sescousse G, Barbalat G, Domenech P, Dreher JC., Psychol Med 43(5), 2013
PMID: 22932231
A further evaluation of decision-making under risk and under ambiguity in schizophrenia.
Fond G, Bayard S, Capdevielle D, Del-Monte J, Mimoun N, Macgregor A, Boulenger JP, Gely-Nargeot MC, Raffard S., Eur Arch Psychiatry Clin Neurosci 263(3), 2013
PMID: 22639243
Decision making under ambiguity but not under risk is related to problem gambling severity.
Brevers D, Cleeremans A, Goudriaan AE, Bechara A, Kornreich C, Verbanck P, Noel X., Psychiatry Res 200(2-3), 2012
PMID: 22521232
Selective decision-making deficits in at-risk gamblers.
Grant JE, Chamberlain SR, Schreiber LR, Odlaug BL, Kim SW., Psychiatry Res 189(1), 2011
PMID: 21715016
Why gamblers fail to win: a review of cognitive and neuroimaging findings in pathological gambling.
van Holst RJ, van den Brink W, Veltman DJ, Goudriaan AE., Neurosci Biobehav Rev 34(1), 2010
PMID: 19632269
Decision making in patients with temporal lobe epilepsy.
Labudda K, Frigge K, Horstmann S, Aengenendt J, Woermann FG, Ebner A, Markowitsch HJ, Brand M., Neuropsychologia 47(1), 2009
PMID: 18789345

68 References

Data provided by Europe PubMed Central.

Decision making in humans: the effect of manipulating the central noradrenergic system
O'Carroll, Journal of Neurology, Neurosurgery and Psychiatry 74(), 2003
The neurobiology of pathological gambling.
Potenza MN., Semin Clin Neuropsychiatry 6(3), 2001
PMID: 11447573
Plasma cortisol and depression in pathological gamblers.
Ramirez LF, McCormick RA, Lowy MT., Br J Psychiatry 153(), 1988
PMID: 3255458
The effects of stress-induced cortisol responses on approach-avoidance behavior.
Roelofs K, Elzinga BM, Rotteveel M., Psychoneuroendocrinology 30(7), 2005
PMID: 15854783
Pathological gambling. A psychobiological study.
Roy A, Adinoff B, Roehrich L, Lamparski D, Custer R, Lorenz V, Barbaccia M, Guidotti A, Costa E, Linnoila M., Arch. Gen. Psychiatry 45(4), 1988
PMID: 2451490
Variation in epinephrine and cortisol excretion rates associated with behavior in an Australian Aboriginal community.
Schmitt LH, Harrison GA, Spargo RM., Am. J. Phys. Anthropol. 106(2), 1998
PMID: 9637187
Modulation of attentional inhibition by norepinephrine and cortisol after psychological stress.
Skosnik PD, Chatterton RT Jr, Swisher T, Park S., Int J Psychophysiol 36(1), 2000
PMID: 10700623

Sturm, 1993
Do somatic markers mediate decisions on the gambling task?
Tomb I, Hauser M, Deldin P, Caramazza A., Nat. Neurosci. 5(11), 2002
PMID: 12403997
Low cortisol levels and the balance between punishment sensitivity and reward dependency.
van Honk J, Schutter DJ, Hermans EJ, Putman P., Neuroreport 14(15), 2003
PMID: 14561936
Salivary alpha amylase as marker for adrenergic activity during stress: effect of betablockade.
van Stegeren A, Rohleder N, Everaerd W, Wolf OT., Psychoneuroendocrinology 31(1), 2006
PMID: 16046076
Perfusion functional MRI reveals cerebral blood flow pattern under psychological stress.
Wang J, Rao H, Wetmore GS, Furlan PM, Korczykowski M, Dinges DF, Detre JA., Proc. Natl. Acad. Sci. U.S.A. 102(49), 2005
PMID: 16306271
The "steroid dementia syndrome": an unrecognized complication of glucocorticoid treatment.
Wolkowitz OM, Lupien SJ, Bigler E, Levin RB, Canick J., Ann. N. Y. Acad. Sci. 1032(), 2004
PMID: 15677408

World, 1994
Stress with simulated trauma management measured by salivary amylase
Xiao, Anesthesiology 93(), 2000
The effects of chronic administration of hydrocortisone on cognitive function in normal male volunteers.
Young AH, Sahakian BJ, Robbins TW, Cowen PJ., Psychopharmacology (Berl.) 145(3), 1999
PMID: 10494574
Development of a sensation-seeking scale
Zuckerman, Journal of Consulting and Clinical Psychology 28(), 1964

Export

0 Marked Publications

Open Data PUB

Web of Science

View record in Web of Science®

Sources

PMID: 17707516
PubMed | Europe PMC

Search this title in

Google Scholar