Decreased osmotic stability of dystrophin-less muscle cells from the mdx mouse

Menke A, Jockusch H (1991)
Nature 349(6304): 69-71.

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Zeitschriftenaufsatz | Veröffentlicht | Englisch
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Abstract / Bemerkung
HUMAN X-linked Duchenne and Becker muscular dystrophies are due to defects in dystrophin, the product of an exceptionally large gene1,2. Although dystrophin has been characterized as a spectrin-like3 submembranous4 cytoskeletal protein, there is no experimental evidence for its function in the structural maintenance of muscle5. Current hypotheses attribute necrosis of hystrophin-less fibres in situ to mechanical weakening of the outer membrane6, to an excessive influx of Ca2+ ions7,8, or to a combination of these two mechanisms, possibly mediated by stretch-sensitive ion channels9. Using hypo-osmotic shock to determine stress resistance10 and a mouse model (mdx)11,12 for the human disease, we show that functional dystrophin contributes to the stability of both cultured myotubes and isolated mature muscle fibres.
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Zeitschriftentitel
Nature
Band
349
Zeitschriftennummer
6304
Seite
69-71
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Menke A, Jockusch H. Decreased osmotic stability of dystrophin-less muscle cells from the mdx mouse. Nature. 1991;349(6304):69-71.
Menke, A., & Jockusch, H. (1991). Decreased osmotic stability of dystrophin-less muscle cells from the mdx mouse. Nature, 349(6304), 69-71. doi:10.1038/349069a0
Menke, A., and Jockusch, H. (1991). Decreased osmotic stability of dystrophin-less muscle cells from the mdx mouse. Nature 349, 69-71.
Menke, A., & Jockusch, H., 1991. Decreased osmotic stability of dystrophin-less muscle cells from the mdx mouse. Nature, 349(6304), p 69-71.
A. Menke and H. Jockusch, “Decreased osmotic stability of dystrophin-less muscle cells from the mdx mouse”, Nature, vol. 349, 1991, pp. 69-71.
Menke, A., Jockusch, H.: Decreased osmotic stability of dystrophin-less muscle cells from the mdx mouse. Nature. 349, 69-71 (1991).
Menke, A, and Jockusch, Harald. “Decreased osmotic stability of dystrophin-less muscle cells from the mdx mouse”. Nature 349.6304 (1991): 69-71.

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Yokota T, Miyagoe-Suzuki Y, Ikemoto T, Matsuda R, Takeda S., Muscle Nerve 49(5), 2014
PMID: 24037898
Atomic force microscopy of 3T3 and SW-13 cell lines: an investigation of cell elasticity changes due to fixation.
Codan B, Martinelli V, Mestroni L, Sbaizero O., Mater Sci Eng C Mater Biol Appl 33(6), 2013
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