Risk factors and cofactors for HTLV-I associated myelopathy / tropical spastic paraparesis (HAM/TSP) in Jamaica

Krämer A, Maloney EM, Morgan OSC, Rodgers-Johnson P, Manns A, Murphy EL, Larsen SA, Cranston B, Murphy JO, Benichou J, Blattner WA (1995)
American Journal of Epidemiology 142(11): 1212-1220.

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Abstract
Human T-cell lymphotropic virus type I (HTLV-I) has been etiologically associated with a neurologic syndrome called HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) as well as with adult T-cell leukemia/lymphoma. The authors sought to quantify the risk in Jamaica of HAM/TSP associated with HTLV-I infection and cofactors associated with this disease among infected individuals. Between 1988 and 1989, prevalent and incident HAM/TSP patients and controls with other neurologic diseases were enrolled in a retrospective study. A second control group was composed of HTLV-I-seropositive, asymptomatic carriers in Jamaica, ascertained in a separate study conducted in 1988. Although HTLV-I seropositivity was not a component of the case definition for HAM/TSP, all 43 HAM/TSP patients were HTLV-I seropositive compared with two (4.0%) of the controls with other neurologic diseases. Given HTLV-I seropositivity, one cofactor associated with the risk of HAM/TSP was young age at initial heterosexual intercourse (odds ratio = 4.00, 95% confidence interval 1.29-12.46 for individuals aged less than or equal to 15; odds ratio = 4.26, 95% confidence interval 1.41-12.90 for individuals aged 16-17 years at initial intercourse). Among individuals who reported this early age at initial sexual intercourse, an increased risk of HAM/TSP was associated with having reported more than five lifetime sexual partners (odds ratio = 2.88, 95% confidence interval 0.90-8.70). Neither an early age at initial sexual intercourse or the number of lifetime sexual partners was a risk factor for adult T-cell leukemia/lymphoma. These data support the hypothesis that HAM/TSP is associated with sexually acquired HTLV-I infection, whereas adult T-cell leukemia/lymphoma is not.
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Krämer A, Maloney EM, Morgan OSC, et al. Risk factors and cofactors for HTLV-I associated myelopathy / tropical spastic paraparesis (HAM/TSP) in Jamaica. American Journal of Epidemiology. 1995;142(11):1212-1220.
Krämer, A., Maloney, E. M., Morgan, O. S. C., Rodgers-Johnson, P., Manns, A., Murphy, E. L., Larsen, S. A., et al. (1995). Risk factors and cofactors for HTLV-I associated myelopathy / tropical spastic paraparesis (HAM/TSP) in Jamaica. American Journal of Epidemiology, 142(11), 1212-1220.
Krämer, A., Maloney, E. M., Morgan, O. S. C., Rodgers-Johnson, P., Manns, A., Murphy, E. L., Larsen, S. A., Cranston, B., Murphy, J. O., Benichou, J., et al. (1995). Risk factors and cofactors for HTLV-I associated myelopathy / tropical spastic paraparesis (HAM/TSP) in Jamaica. American Journal of Epidemiology 142, 1212-1220.
Krämer, A., et al., 1995. Risk factors and cofactors for HTLV-I associated myelopathy / tropical spastic paraparesis (HAM/TSP) in Jamaica. American Journal of Epidemiology, 142(11), p 1212-1220.
A. Krämer, et al., “Risk factors and cofactors for HTLV-I associated myelopathy / tropical spastic paraparesis (HAM/TSP) in Jamaica”, American Journal of Epidemiology, vol. 142, 1995, pp. 1212-1220.
Krämer, A., Maloney, E.M., Morgan, O.S.C., Rodgers-Johnson, P., Manns, A., Murphy, E.L., Larsen, S.A., Cranston, B., Murphy, J.O., Benichou, J., Blattner, W.A.: Risk factors and cofactors for HTLV-I associated myelopathy / tropical spastic paraparesis (HAM/TSP) in Jamaica. American Journal of Epidemiology. 142, 1212-1220 (1995).
Krämer, Alexander, Maloney, E. M., Morgan, O. St. C., Rodgers-Johnson, P., Manns, A., Murphy, E. L., Larsen, S. A., Cranston, B., Murphy, J. O., Benichou, J., and Blattner, W. A. “Risk factors and cofactors for HTLV-I associated myelopathy / tropical spastic paraparesis (HAM/TSP) in Jamaica”. American Journal of Epidemiology 142.11 (1995): 1212-1220.
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