Engineering antibiotic producers to overcome the limitations of classical strain improvement programs

Lal R, Khanna R, Kaur H, Khanna M, Dhingra N, Lal S, Gartemann K-H, Eichenlaub R, Ghosh PK (1996)
CRITICAL REVIEWS IN MICROBIOLOGY 22(4): 201-255.

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Zeitschriftenaufsatz | Veröffentlicht | Englisch
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Abstract / Bemerkung
Improvement of the antibiotic yield of industrial strains is invariably the main target of industry-oriented research. The approaches used in the past were rational selection, extensive mutagenesis, and biochemical screening. These approaches have their limitations, which are likely to be overcome by the judicious application of recombinant DNA techniques. Efficient cloning Vectors and transformation systems have now become available even for antibiotic producers that were previously difficult to manipulate genetically. The genes responsible for antibiotic biosynthesis can now be easily isolated and manipulated. In the first half of this review article, the limitations of classical strain improvement programs and the development of recombinant DNA techniques for cloning and analyzing genes responsible for antibiotic biosynthesis are discussed. The second half of this article addresses some of the major achievements, including the development of genetically engineered microbes, especially with reference to p-lactams, anthracyclines, and rifamycins.
Erscheinungsjahr
Zeitschriftentitel
CRITICAL REVIEWS IN MICROBIOLOGY
Band
22
Zeitschriftennummer
4
Seite
201-255
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Lal R, Khanna R, Kaur H, et al. Engineering antibiotic producers to overcome the limitations of classical strain improvement programs. CRITICAL REVIEWS IN MICROBIOLOGY. 1996;22(4):201-255.
Lal, R., Khanna, R., Kaur, H., Khanna, M., Dhingra, N., Lal, S., Gartemann, K. - H., et al. (1996). Engineering antibiotic producers to overcome the limitations of classical strain improvement programs. CRITICAL REVIEWS IN MICROBIOLOGY, 22(4), 201-255. doi:10.3109/10408419609105481
Lal, R., Khanna, R., Kaur, H., Khanna, M., Dhingra, N., Lal, S., Gartemann, K. - H., Eichenlaub, R., and Ghosh, P. K. (1996). Engineering antibiotic producers to overcome the limitations of classical strain improvement programs. CRITICAL REVIEWS IN MICROBIOLOGY 22, 201-255.
Lal, R., et al., 1996. Engineering antibiotic producers to overcome the limitations of classical strain improvement programs. CRITICAL REVIEWS IN MICROBIOLOGY, 22(4), p 201-255.
R. Lal, et al., “Engineering antibiotic producers to overcome the limitations of classical strain improvement programs”, CRITICAL REVIEWS IN MICROBIOLOGY, vol. 22, 1996, pp. 201-255.
Lal, R., Khanna, R., Kaur, H., Khanna, M., Dhingra, N., Lal, S., Gartemann, K.-H., Eichenlaub, R., Ghosh, P.K.: Engineering antibiotic producers to overcome the limitations of classical strain improvement programs. CRITICAL REVIEWS IN MICROBIOLOGY. 22, 201-255 (1996).
Lal, R, Khanna, R, Kaur, H, Khanna, M, Dhingra, N, Lal, S, Gartemann, Karl-Heinz, Eichenlaub, Rudolf, and Ghosh, PK. “Engineering antibiotic producers to overcome the limitations of classical strain improvement programs”. CRITICAL REVIEWS IN MICROBIOLOGY 22.4 (1996): 201-255.

12 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Bioprocess intensification of antibiotic production by Streptomyces coelicolor A3(2) in micro-porous culture.
Ndlovu TM, Ward AC, Glassey J, Eskildsen J, Akay G., Mater Sci Eng C Mater Biol Appl 49(), 2015
PMID: 25687011
Modification of rifamycin polyketide backbone leads to improved drug activity against rifampicin-resistant Mycobacterium tuberculosis.
Nigam A, Almabruk KH, Saxena A, Yang J, Mukherjee U, Kaur H, Kohli P, Kumari R, Singh P, Zakharov LN, Singh Y, Mahmud T, Lal R., J Biol Chem 289(30), 2014
PMID: 24923585
A key developmental regulator controls the synthesis of the antibiotic erythromycin in Saccharopolyspora erythraea.
Chng C, Lum AM, Vroom JA, Kao CM., Proc Natl Acad Sci U S A 105(32), 2008
PMID: 18685110
Streptomyces genetics: a genomic perspective.
Paradkar A, Trefzer A, Chakraburtty R, Stassi D., Crit Rev Biotechnol 23(1), 2003
PMID: 12693442
Innovative approach for improvement of an antibiotic-overproducing industrial strain of Streptomyces albus.
Tamehiro N, Hosaka T, Xu J, Hu H, Otake N, Ochi K., Appl Environ Microbiol 69(11), 2003
PMID: 14602594
Regulation and manipulation of the gene clusters encoding type-I PKSs.
Lal R, Kumari R, Kaur H, Khanna R, Dhingra N, Tuteja D., Trends Biotechnol 18(6), 2000
PMID: 10802562

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