Integrated radiation hybrid map of human chromosome 2p13: Possible involvement of dynactin in neuromuscular diseases

Korthaus D, Wedemeyer N, Lengeling A, Ronsiek M, Jockusch H, SchmittJohn T (1997)
Genomics 43(2): 242-244.

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Zeitschriftenaufsatz | Veröffentlicht | Englisch
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Abstract / Bemerkung
The genes for the human neuromuscular diseases limb-girdle muscular dystrophy type 2B (LGMD2B) and Miyoshi myopathy are located on chromosome 2p13p14, and two neuromuscular mutations of the mouse have been mapped to regions homologous to human chromosome 2p13 by conserved synteny, wobbler (wr) on proximal Chr 11 and motor neuron degeneration 2 (mnd2) on Chr 6. Neither one is a mouse homologue of LGMD2B. Recently the gene DCTN1, coding for the large subunit of the cytoskeletal protein dynactin, was shown by FISH to be located in this region and therefore should be considered a candidate for all these disease genes, Here we present mapping data based on radiation hybrid and physical mapping that more precisely define the location of nine genetic markers in the critical region and the homology relationship of human chromosome 2p with mouse proximal Chr 11 and Chr 6. The human dynactin gene was mapped between markers TGFA and D2S1394, implying that the mouse dynactin gene Dctn1 is located on Chr 6, distal to mnd2. Thus DCTN1/Dctn1 is a candidate for LGMD2B but not for mnd2 or wr. (C) 1997 Academic Press.
Erscheinungsjahr
Zeitschriftentitel
Genomics
Band
43
Zeitschriftennummer
2
Seite
242-244
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Korthaus D, Wedemeyer N, Lengeling A, Ronsiek M, Jockusch H, SchmittJohn T. Integrated radiation hybrid map of human chromosome 2p13: Possible involvement of dynactin in neuromuscular diseases. Genomics. 1997;43(2):242-244.
Korthaus, D., Wedemeyer, N., Lengeling, A., Ronsiek, M., Jockusch, H., & SchmittJohn, T. (1997). Integrated radiation hybrid map of human chromosome 2p13: Possible involvement of dynactin in neuromuscular diseases. Genomics, 43(2), 242-244. doi:10.1006/geno.1997.4789
Korthaus, D., Wedemeyer, N., Lengeling, A., Ronsiek, M., Jockusch, H., and SchmittJohn, T. (1997). Integrated radiation hybrid map of human chromosome 2p13: Possible involvement of dynactin in neuromuscular diseases. Genomics 43, 242-244.
Korthaus, D., et al., 1997. Integrated radiation hybrid map of human chromosome 2p13: Possible involvement of dynactin in neuromuscular diseases. Genomics, 43(2), p 242-244.
D. Korthaus, et al., “Integrated radiation hybrid map of human chromosome 2p13: Possible involvement of dynactin in neuromuscular diseases”, Genomics, vol. 43, 1997, pp. 242-244.
Korthaus, D., Wedemeyer, N., Lengeling, A., Ronsiek, M., Jockusch, H., SchmittJohn, T.: Integrated radiation hybrid map of human chromosome 2p13: Possible involvement of dynactin in neuromuscular diseases. Genomics. 43, 242-244 (1997).
Korthaus, D, Wedemeyer, N, Lengeling, A, Ronsiek, M, Jockusch, Harald, and SchmittJohn, T. “Integrated radiation hybrid map of human chromosome 2p13: Possible involvement of dynactin in neuromuscular diseases”. Genomics 43.2 (1997): 242-244.

8 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

VPS54 and the wobbler mouse.
Schmitt-John T., Front Neurosci 9(), 2015
PMID: 26539077
The wobbler mouse, an ALS animal model.
Moser JM, Bigini P, Schmitt-John T., Mol Genet Genomics 288(5-6), 2013
PMID: 23539154
The wobbler mouse: a neurodegeneration jigsaw puzzle.
Boillée S, Peschanski M, Junier MP., Mol Neurobiol 28(1), 2003
PMID: 14514986
Genetic modifiers that aggravate the neurological phenotype of the wobbler mouse.
Ulbrich M, Schmidt VC, Ronsiek M, Mussmann A, Bartsch JW, Augustin M, Jockusch H, Schmitt-John T., Neuroreport 13(4), 2002
PMID: 11930176
Genetic linkage of Welander distal myopathy to chromosome 2p13.
Ahlberg G, von Tell D, Borg K, Edström L, Anvret M., Ann Neurol 46(3), 1999
PMID: 10482271

21 References

Daten bereitgestellt von Europe PubMed Central.

Epilepsy and brain abnormalities in mice lacking the Otx1 gene.
Acampora D, Mazan S, Avantaggiato V, Barone P, Tuorto F, Lallemand Y, Brulet P, Simeone A., Nat. Genet. 14(2), 1996
PMID: 8841200
Genetic and physical mapping at the limb-girdle muscular dystrophy locus (LGMD2B) on chromosome 2p.
Bashir R, Keers S, Strachan T, Passos-Bueno R, Zatz M, Weissenbach J, Le Paslier D, Meisler M, Bushby K., Genomics 33(1), 1996
PMID: 8617508
Linkage of Miyoshi myopathy (distal autosomal recessive muscular dystrophy) locus to chromosome 2p12-14.
Bejaoui K, Hirabayashi K, Hentati F, Haines JL, Ben Hamida C, Belal S, Miller RG, McKenna-Yasek D, Weissenbach J, Rowland LP., Neurology 45(4), 1995
PMID: 7723968
Regional localization of the human c-rel locus using translocation chromosome analysis.
Brownell E, Fell HP, Tucker PW, Geurts van Kessel AH, Hagemeijer A, Rice NR., Oncogene 2(5), 1988
PMID: 3287280
Neural-specific expression, genomic structure and chromosomal location of the gene encoding the zinc-finger transcription factor NGFI-C
Crosby, Proc. Nat. Acad. Sci. USA 89(), 1992
Genetic mapping of the homeobox-containing geneOtx1
De, Mamm. Genome 7(), 1995
mnd2: a new mouse model of inherited motor neuron disease.
Jones JM, Albin RL, Feldman EL, Simin K, Schuster TG, Dunnick WA, Collins JT, Chrisp CE, Taylor BA, Meisler MH., Genomics 16(3), 1993
PMID: 8325640
Chromosome locations of human EMX and OTX genes.
Kastury K, Druck T, Huebner K, Barletta C, Acampora D, Simeone A, Faiella A, Boncinelli E., Genomics 22(1), 1994
PMID: 7959790
The gene for cytoplasmatic malate dehydrogenase,Mor2,wr
Korthaus, Mamm. Genome 7(), 1995
Molecular cloning, cDNA sequence, and bacterial expression of human glutamine:fructose-6-phosphate amidotransferase.
McKnight GL, Mudri SL, Mathewes SL, Traxinger RR, Marshall S, Sheppard PO, O'Hara PJ., J. Biol. Chem. 267(35), 1992
PMID: 1460020
Meis1, a PBX1-related homeobox gene involved in myeloid leukemia in BXH-2 mice.
Moskow JJ, Bullrich F, Huebner K, Daar IO, Buchberg AM., Mol. Cell. Biol. 15(10), 1995
PMID: 7565694

O'Brian, 1993
Molecular cloning and mapping of a human cDNA for cytosolic malate dehydrogenase (MDH1).
Tanaka T, Inazawa J, Nakamura Y., Genomics 32(1), 1996
PMID: 8786100
The gene for human transforming growth factor alpha is on the short arm of chromosome 2.
Tricoli JV, Nakai H, Byers MG, Rall LB, Bell GI, Shows TB., Cytogenet. Cell Genet. 42(1-2), 1986
PMID: 3459638
A method for constructing radiation hybrid maps of whole genomes.
Walter MA, Spillett DJ, Thomas P, Weissenbach J, Goodfellow PN., Nat. Genet. 7(1), 1994
PMID: 8075634
The p150Glued component of the dynactin complex binds to both microtubules and the actin-related protein centractin (Arp-1).
Waterman-Storer CM, Karki S, Holzbaur EL., Proc. Natl. Acad. Sci. U.S.A. 92(5), 1995
PMID: 7878030

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