The human gene ZFP161 on 18p11.21-pter encodes a putative c-myc repressor and is homologous to murine Zfp161 (chr 17) and Zfp161-rs1 (X chr)

Sobek-Klocke I, Disque-Kochem C, Ronsiek M, Klocke R, Jockusch H, Breuning A, Ponstingl H, Rojas K, Overhauser J, Eichenlaub-Ritter U (1997)
Genomics 43(2): 156-164.

Journal Article | Published | English

No fulltext has been uploaded

Author
; ; ; ; ; ; ; ; ;
Abstract
A clone from a lambda gt11 cDNA expression library of HeLa cells was isolated, sequenced, and shown to encode a new human zinc finger protein. The cDNA of the gene termed ZFP161 has an open reading frame of 1347 bp. The predicted protein comprises 449 amino acid residues and contains five zinc finger motifs of the Kruppel type near the C-terminus and a BTB/POZ domain in the N-terminal region. The protein is 98% homologous to a murine zinc finger protein, ZP5 (M. Numoto et al., 1993, Nucleic Acids Res. 21: 3767-3775), which is a putative transcriptional repressor of c-myc and exhibits growth-suppressive activity in mouse cell lines. Through the use of a panel of somatic cell hybrids for chromosomal assignment and DNAs of somatic cell hybrids containing a deleted chromosome 18 for fine mapping, the human gene ZFP161 was localized to 18p11.21-pter. Therefore, ZFP161 is a candidate gene by position for the holoprosencephaly type 4 gene, HPE4, which is involved in congenital malformations. With DNAs from an interspecific backcross, two homologous mouse genes, Zfp161 and Zfp161-rs1, were mapped to chromosome 17 and the X chromosome, respectively. Mapping of Zfp161 confirms and extends a region of homology between distal mouse chromosome 17 and human 18p. (C) 1997 Academic Press.
Publishing Year
ISSN
PUB-ID

Cite this

Sobek-Klocke I, Disque-Kochem C, Ronsiek M, et al. The human gene ZFP161 on 18p11.21-pter encodes a putative c-myc repressor and is homologous to murine Zfp161 (chr 17) and Zfp161-rs1 (X chr). Genomics. 1997;43(2):156-164.
Sobek-Klocke, I., Disque-Kochem, C., Ronsiek, M., Klocke, R., Jockusch, H., Breuning, A., Ponstingl, H., et al. (1997). The human gene ZFP161 on 18p11.21-pter encodes a putative c-myc repressor and is homologous to murine Zfp161 (chr 17) and Zfp161-rs1 (X chr). Genomics, 43(2), 156-164.
Sobek-Klocke, I., Disque-Kochem, C., Ronsiek, M., Klocke, R., Jockusch, H., Breuning, A., Ponstingl, H., Rojas, K., Overhauser, J., and Eichenlaub-Ritter, U. (1997). The human gene ZFP161 on 18p11.21-pter encodes a putative c-myc repressor and is homologous to murine Zfp161 (chr 17) and Zfp161-rs1 (X chr). Genomics 43, 156-164.
Sobek-Klocke, I., et al., 1997. The human gene ZFP161 on 18p11.21-pter encodes a putative c-myc repressor and is homologous to murine Zfp161 (chr 17) and Zfp161-rs1 (X chr). Genomics, 43(2), p 156-164.
I. Sobek-Klocke, et al., “The human gene ZFP161 on 18p11.21-pter encodes a putative c-myc repressor and is homologous to murine Zfp161 (chr 17) and Zfp161-rs1 (X chr)”, Genomics, vol. 43, 1997, pp. 156-164.
Sobek-Klocke, I., Disque-Kochem, C., Ronsiek, M., Klocke, R., Jockusch, H., Breuning, A., Ponstingl, H., Rojas, K., Overhauser, J., Eichenlaub-Ritter, U.: The human gene ZFP161 on 18p11.21-pter encodes a putative c-myc repressor and is homologous to murine Zfp161 (chr 17) and Zfp161-rs1 (X chr). Genomics. 43, 156-164 (1997).
Sobek-Klocke, I, Disque-Kochem, C, Ronsiek, M, Klocke, R, Jockusch, Harald, Breuning, A, Ponstingl, H, Rojas, K, Overhauser, J, and Eichenlaub-Ritter, Ursula. “The human gene ZFP161 on 18p11.21-pter encodes a putative c-myc repressor and is homologous to murine Zfp161 (chr 17) and Zfp161-rs1 (X chr)”. Genomics 43.2 (1997): 156-164.
This data publication is cited in the following publications:
This publication cites the following data publications:

19 Citations in Europe PMC

Data provided by Europe PubMed Central.

Computational modeling identifies key gene regulatory interactions underlying phenobarbital-mediated tumor promotion.
Luisier R, Unterberger EB, Goodman JI, Schwarz M, Moggs J, Terranova R, van Nimwegen E., Nucleic Acids Res. 42(7), 2014
PMID: 24464994
Systematic dissection of regulatory motifs in 2000 predicted human enhancers using a massively parallel reporter assay.
Kheradpour P, Ernst J, Melnikov A, Rogov P, Wang L, Zhang X, Alston J, Mikkelsen TS, Kellis M., Genome Res. 23(5), 2013
PMID: 23512712
Systems genetics implicates cytoskeletal genes in oocyte control of cloned embryo quality.
Cheng Y, Gaughan J, Midic U, Han Z, Liang CG, Patel BG, Latham KE., Genetics 193(3), 2013
PMID: 23307892
Mouse chromosome 17 candidate modifier genes for thrombosis.
Sa Q, Hart E, Nadeau JH, Hoover-Plow JL., Mamm. Genome 21(7-8), 2010
PMID: 20700597
Loss, mutation and deregulation of L3MBTL4 in breast cancers.
Addou-Klouche L, Adelaide J, Finetti P, Cervera N, Ferrari A, Bekhouche I, Sircoulomb F, Sotiriou C, Viens P, Moulessehoul S, Bertucci F, Birnbaum D, Chaffanet M., Mol. Cancer 9(), 2010
PMID: 20698951
Male infertility and the involvement of the X chromosome.
Stouffs K, Tournaye H, Liebaers I, Lissens W., Hum. Reprod. Update 15(6), 2009
PMID: 19515807
Prediction of Cis-Regulatory Elements Controlling Genes Differentially Expressed by Retinal and Choroidal Vascular Endothelial Cells.
Choi D, Appukuttan B, Binek SJ, Planck SR, Stout JT, Rosenbaum JT, Smith JR., J Ocul Biol Dis Infor 1(1), 2008
PMID: 19122891
Novel repressor of the human FMR1 gene - identification of p56 human (GCC)(n)-binding protein as a Kruppel-like transcription factor ZF5.
Orlov SV, Kuteykin-Teplyakov KB, Ignatovich IA, Dizhe EB, Mirgorodskaya OA, Grishin AV, Guzhova OB, Prokhortchouk EB, Guliy PV, Perevozchikov AP., FEBS J. 274(18), 2007
PMID: 17714511
Non-multifactorial neural tube defects.
Lynch SA., Am J Med Genet C Semin Med Genet 135C(1), 2005
PMID: 15800854
Novel human BTB/POZ domain-containing zinc finger protein ZNF295 is directly associated with ZFP161.
Wang J, Kudoh J, Takayanagi A, Shimizu N., Biochem. Biophys. Res. Commun. 327(2), 2005
PMID: 15629158
Human zinc finger protein 161, a novel transcriptional activator of the dopamine transporter.
Lee KH, Kwak YD, Kim DH, Chang MY, Lee YS, Lee YS., Biochem. Biophys. Res. Commun. 313(4), 2004
PMID: 14706637
Epigenetic and gene expression changes related to transgenerational carcinogenesis.
Cheng RY, Hockman T, Crawford E, Anderson LM, Shiao YH., Mol. Carcinog. 40(1), 2004
PMID: 15108325
Frontonasal dysplasia in 3H1 Br/Br mice.
McBratney BM, Margaryan E, Ma W, Urban Z, Lozanoff S., Anat Rec A Discov Mol Cell Evol Biol 271(2), 2003
PMID: 12629672
Quality indicators increase the reliability of microarray data.
Raffelsberger W, Dembele D, Neubauer MG, Gottardis MM, Gronemeyer H., Genomics 80(4), 2002
PMID: 12376092
Identification of human autoantibodies to the transcriptional repressor ZF5.
Yanagidani A, Matsuoka M, Yokoro K, Tanaka H, Numoto M., J. Autoimmun. 15(1), 2000
PMID: 10936031
Early onset of gastric carcinoma and constitutional deletion of 18p.
Dellavecchia C, Guala A, Olivieri C, Haintink O, Cadario F, Luinetti O, Fiocca R, Minelli A, Danesino C, Bona G., Cancer Genet. Cytogenet. 113(1), 1999
PMID: 10459356
ZF5, which is a Kruppel-type transcriptional repressor, requires the zinc finger domain for self-association.
Numoto M, Yokoro K, Koshi J., Biochem. Biophys. Res. Commun. 256(3), 1999
PMID: 10080939
Genomic cloning and characterization of the mouse POZ/zinc-finger protein ZF5.
Yokoro K, Yanagidani A, Obata T, Yamamoto S, Numoto M., Biochem. Biophys. Res. Commun. 246(3), 1998
PMID: 9618270

Export

0 Marked Publications

Open Data PUB

Web of Science

View record in Web of Science®

Sources

PMID: 9244432
PubMed | Europe PMC

Search this title in

Google Scholar