Ca-dependent regulation of Na+-selective channels via actin cytoskeleton modification in leukemia cells

Maximov AV, Vedernikova EA, Hinssen H, Khaitlina SY, Negulyaev YA (1997)
FEBS LETTERS 412(1): 94-96.

Download
No fulltext has been uploaded. References only!
Journal Article | Original Article | Published | English

No fulltext has been uploaded

Author
; ; ; ;
Abstract / Notes
With the use of the patch-clamp technique, physiological mechanisms of Na+ channel regulation involving submembranous actin rearrangements were examined in human myeloid leukemia K562 cells. We found that the actin-severing protein gelsolin applied to cytoplasmic surface of membrane fragments at a high level of [Ca2+](i) (1 mu M) increased drastically the activity of Na-selective channels of 12 pS unitary conductance. In the experiments on intact cells, the elevation of [Ca2+](i) using the ionophore 4Br-A23187 also resulted in Na+ channel activation. Addition of actin to the cytoplasmic surface of membrane patches reduced this activity to background level, likely due to actin polymerization. Our data imply that Ca-dependent modulations of the actin cytoskeleton may represent one of the general mechanisms of channel regulation and cell signalling. (C) 1997 Federation of European Biochemical Societies.
Publishing Year
ISSN
PUB-ID

Cite this

Maximov AV, Vedernikova EA, Hinssen H, Khaitlina SY, Negulyaev YA. Ca-dependent regulation of Na+-selective channels via actin cytoskeleton modification in leukemia cells. FEBS LETTERS. 1997;412(1):94-96.
Maximov, A. V., Vedernikova, E. A., Hinssen, H., Khaitlina, S. Y., & Negulyaev, Y. A. (1997). Ca-dependent regulation of Na+-selective channels via actin cytoskeleton modification in leukemia cells. FEBS LETTERS, 412(1), 94-96. doi:10.1016/S0014-5793(97)00754-0
Maximov, A. V., Vedernikova, E. A., Hinssen, H., Khaitlina, S. Y., and Negulyaev, Y. A. (1997). Ca-dependent regulation of Na+-selective channels via actin cytoskeleton modification in leukemia cells. FEBS LETTERS 412, 94-96.
Maximov, A.V., et al., 1997. Ca-dependent regulation of Na+-selective channels via actin cytoskeleton modification in leukemia cells. FEBS LETTERS, 412(1), p 94-96.
A.V. Maximov, et al., “Ca-dependent regulation of Na+-selective channels via actin cytoskeleton modification in leukemia cells”, FEBS LETTERS, vol. 412, 1997, pp. 94-96.
Maximov, A.V., Vedernikova, E.A., Hinssen, H., Khaitlina, S.Y., Negulyaev, Y.A.: Ca-dependent regulation of Na+-selective channels via actin cytoskeleton modification in leukemia cells. FEBS LETTERS. 412, 94-96 (1997).
Maximov, AV, Vedernikova, EA, Hinssen, Horst, Khaitlina, SY, and Negulyaev, YA. “Ca-dependent regulation of Na+-selective channels via actin cytoskeleton modification in leukemia cells”. FEBS LETTERS 412.1 (1997): 94-96.
This data publication is cited in the following publications:
This publication cites the following data publications:

19 Citations in Europe PMC

Data provided by Europe PubMed Central.

Possible role of non-muscle alpha-actinins in muscle cell mechanosensitivity.
Ogneva IV, Biryukov NS, Leinsoo TA, Larina IM., PLoS One 9(4), 2014
PMID: 24780915
Mechanical characteristics of mesenchymal stem cells under impact of silica-based nanoparticles.
Ogneva IV, Buravkov SV, Shubenkov AN, Buravkova LB., Nanoscale Res Lett 9(1), 2014
PMID: 24948901
Serum- and glucocorticoid-inducible kinase SGK1 regulates reorganization of actin cytoskeleton in mast cells upon degranulation.
Schmid E, Gu S, Yang W, Münzer P, Schaller M, Lang F, Stournaras C, Shumilina E., Am J Physiol Cell Physiol 304(1), 2013
PMID: 23015548
Development of a multilevel approach for the evaluation of nanomaterials' toxicity.
Galluzzi L, Chiarantini L, Pantucci E, Curci R, Merikhi J, Hummel H, Bachmann PK, Manuali E, Pezzotti G, Magnani M., Nanomedicine (Lond) 7(3), 2012
PMID: 22047028
Regulation of sodium channel activity by capping of actin filaments.
Shumilina EV, Negulyaev YA, Morachevskaya EA, Hinssen H, Khaitlina SY., Mol Biol Cell 14(4), 2003
PMID: 12686620
Non-hydrolyzable analog of GTP induces activity of Na+ channels via disassembly of cortical actin cytoskeleton.
Shumilina EV, Khaitlina SY, Morachevskaya EA, Negulyaev YA., FEBS Lett 547(1-3), 2003
PMID: 12860381
CFTR in K562 human leukemic cells.
Assef YA, Damiano AE, Zotta E, Ibarra C, Kotsias BA., Am J Physiol Cell Physiol 285(2), 2003
PMID: 12842835
Mineralocorticoid receptor-mediated signaling regulates the ion gated sodium channel in vascular endothelial cells and requires an intact cytoskeleton.
Golestaneh N, Klein C, Valamanesh F, Suarez G, Agarwal MK, Mirshahi M., Biochem Biophys Res Commun 280(5), 2001
PMID: 11162670
Regions in the carboxy terminus of alpha-bENaC involved in gating and functional effects of actin.
Copeland SJ, Berdiev BK, Ji HL, Lockhart J, Parker S, Fuller CM, Benos DJ., Am J Physiol Cell Physiol 281(1), 2001
PMID: 11401846
Reorganization of actin in neurons after propofol exposure.
Oscarsson A, Massoumi R, Sjölander A, Eintrei C., Acta Anaesthesiol Scand 45(10), 2001
PMID: 11736672
General overview of mineralocorticoid hormone action.
Agarwal MK, Mirshahi M., Pharmacol Ther 84(3), 1999
PMID: 10665831
Ca2+ regulation of gelsolin activity: binding and severing of F-actin.
Kinosian HJ, Newman J, Lincoln B, Selden LA, Gershman LC, Estes JE., Biophys J 75(6), 1998
PMID: 9826630

Export

0 Marked Publications

Open Data PUB

Web of Science

View record in Web of Science®

Sources

PMID: 9257697
PubMed | Europe PMC

Search this title in

Google Scholar